Normoglycemic plasma glucose levels affect F-18 FDG uptake in the brain

Claeys, Jana; Mertens, Koen; D’Asseler, Yves; Goethals, Ingeborg

doi:10.1007/s12149-010-0359-9

Cited by 24 publications

(24 citation statements)

References 21 publications

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“…Similar to prior reports, we found that cerebral cortical FDG uptake has a negative inverse relationship to plasma blood glucose levels; with decreasing brain SUV as blood glucose levels increase [4,5]. Our inclusion of oncology patients rather than normal subjects allowed us to consider plasma blood glucose levels as a continual variable resulting in linear regression modeling rather than categorical comparisons.…”

Section: Discussionsupporting

confidence: 74%

“…Quantitative parametric imaging techniques have further improved brain PET diagnostic accuracy, interobserver agreement and reader training [2,3]. Hyperglycemia is known to influence brain FDG uptake [4,5], and consensus imaging protocols advise brain FDG PET/CT after a 4 h fast to achieve desirable blood glucose levels in the range of <160 mg/dL, as a threshold for hyperglycemia [6–8]. However, two recent studies report concern that milder degrees of hyperglycemia could potentially confound brain FDG PET/CT imaging by producing patterns of decreased cortical brain FDG uptake that could potentially mimic patterns seen in Alzheimer disease, using quantitative voxel-based parametric techniques [9,10].…”

Section: Introductionmentioning

confidence: 99%

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Effect of hyperglycemia on brain and liver 18 F-FDG standardized uptake value (FDG SUV) measured by quantitative positron emission tomography (PET) imaging

Viglianti

Wong

Wimer³

et al. 2017

Biomedicine & Pharmacotherapy

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Purpose Blood glucose is routinely measured prior to 18F-fluorodeoxyglucose (FDG) administration in positron emission tomography (PET) imaging to identify hyperglycemia that may affect image quality. In this study we explore the effects of blood glucose levels upon semi-quantitative standardized uptake value (SUV) measurements of target organs and tissues of interest and in particular address the relationship of blood glucose to FDG accumulation in the brain and liver. Methods 436 FDG PET/CT consecutive studies performed for oncology staging in 229 patients (226 male) at the Ann Arbor Veterans Administration Healthcare System were reviewed. All patients had blood glucose measured (112.4 ± 34.1 mg/dL) prior to injection of 466.2 ± 51.8 MBq (12.6 ± 1.4 mCi) of FDG. SUV measurements of brain, aortic arch blood-pool, liver, and spleen were obtained at 64.5 ±10.2 min’ post-injection. Results We found a negative inverse relationship of brain SUV with increasing plasma glucose, levels for both absolute and normalized (either to blood-pool or liver) values. Higher blood glucose levels had a mild effect upon liver and blood-pool SUV. By contrast, spleen SUV was independent of blood glucose, but demonstrated the greatest variability (deviation on linear regression). In contrast to other tissues, liver and spleen SUV normalized to blood-pool SUV were not dependent upon blood glucose levels. Conclusion The effects of hyperglycemia upon FDG uptake in brain and liver, over a range of blood glucose values generally considered acceptable for clinical PET imaging, may have measurable effects on semi-quantitative image analysis.

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Section: Discussionsupporting

confidence: 74%

Section: Introductionmentioning

confidence: 99%

Effect of hyperglycemia on brain and liver 18 F-FDG standardized uptake value (FDG SUV) measured by quantitative positron emission tomography (PET) imaging

Viglianti

Wong

Wimer³

et al. 2017

Biomedicine & Pharmacotherapy

View full text Add to dashboard Cite

show abstract

“…and compatible glucose uptake in the brain. Similar to prior studies, cerebral cortical FDG uptake had a negative relationship with blood glucose levels in this study (12,13).…”

Section: Resultssupporting

confidence: 90%

The Relation Between the Blood Glucose Level and the FDG Uptake of Tissues at Normal or Near-Normal PET/CT Imaging

Cengiz¹

2018

Akd Med J

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Objective: The aim of this study was to evaluate the relation between the blood glucose level and 18F-FDG uptake in tissues at normal or near-normal PET/CT examinations. Material and Methods: Patients with newly diagnosed cancer who underwent 18F-FDG PET/ CT for initial staging were evaluated retrospectively. Sixty five patients (47 female, 18 male) with a normal or near normal FDG distribution were included this study. Mean standardized uptake value of the brain, heart, lung, mediastinum, pancreas, liver, spleen, skeletal muscle and bone marrow were calculated. Blood glucose levels measured immediately prior to administration of FDG were used. Results: There was a statistically significant positive correlation between the blood glucose level and liver and muscular FDG uptake. Brain FDG uptake value was negatively correlated with the glucose level. There was no correlation between the blood glucose level and other tissues' FDG uptake values. The patients with increased blood glucose levels showed significantly higher muscular and lower brain FDG uptake compared with patients with normal glucose levels. Conclusion: Effect of hyperglycemia during 18F FDG PET/CT imaging on normal tissues is variable. While skeletal muscle and brain are the most affected tissues, the liver is slightly affected in a clinically insignificant manner.

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“…Emission sinograms were normalized and corrected for attenuation and decay of radioactivity and iteratively reconstructed using OSEM2D (4 iterations and 16 subsets). 31 PET data were not corrected for blood glucose levels, because previous reports indicate that glucose correction does not improve the inter-subject variability 32 and it may even introduce more noise. 33 A 10-minutes frame of the [ 18 F]FDG PET scan, starting 50 minutes post injection, was used to explore the differences in brain glucose metabolism between the groups.…”

Section: Pet Image Reconstruction and Analysismentioning

confidence: 99%

Therapeutic effects of dietary intervention on neuroinflammation and brain metabolism in a rat model of photothrombotic stroke

et al. 2018

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Normoglycemic plasma glucose levels affect F-18 FDG uptake in the brain

Cited by 24 publications

References 21 publications

Effect of hyperglycemia on brain and liver 18 F-FDG standardized uptake value (FDG SUV) measured by quantitative positron emission tomography (PET) imaging

Effect of hyperglycemia on brain and liver 18 F-FDG standardized uptake value (FDG SUV) measured by quantitative positron emission tomography (PET) imaging

The Relation Between the Blood Glucose Level and the FDG Uptake of Tissues at Normal or Near-Normal PET/CT Imaging

Therapeutic effects of dietary intervention on neuroinflammation and brain metabolism in a rat model of photothrombotic stroke

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