Normoxic low‐altitude simulation (at 714 mmHg) improves limb blood perfusion in mice with hindlimb ischemia

Abstract

Atherosclerosis contributes to a myriad of cardiovascular diseases, including peripheral arterial disease (PAD), which is caused by atherosclerotic plaques in the leg arteries leading to arterial stenosis or occlusion (Hirsch, 2006). The resulting ischemia can be very severe, causing pain on rest and tissue loss through ulceration and gangrene (Morley et al., 2018).