North American Propolis Extracts From Upstate New York Decrease Nosema ceranae (Microsporidia) Spore Levels in Honey Bees (Apis mellifera)

Burnham, Andre J.; Jong, Emily De; Jones, Jayre A; Lehman, Herman K.

doi:10.3389/fmicb.2020.01719

Cited by 8 publications

(4 citation statements)

References 47 publications

(70 reference statements)

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“…Supplementation with proteins such as propolis and pollen was shown to prevent clinical signs of infection. Pollen supplementation increases the transcription of genes related to the expression of Vg and other important bioprocesses in infected bees [ 116 , 117 ], and administration of propolis extract decreases N. ceranae spore levels in honeybees [ 118 , 119 ]. Suwannapong et al (2018) observed a reduction in both mortality and infection rates after oral administration of propolis in Apis florea [ 120 ].…”

Section: Current Insights On Treatmentmentioning

confidence: 99%

The Role of Nosema ceranae (Microsporidia: Nosematidae) in Honey Bee Colony Losses and Current Insights on Treatment

Marín-García

Peyre

Ahuir-Baraja

et al. 2022

Veterinary Sciences

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Honeybee populations have locally and temporally declined in the last few years because of both biotic and abiotic factors. Among the latter, one of the most important reasons is infection by the microsporidia Nosema ceranae, which is the etiological agent of type C nosemosis. This species was first described in Asian honeybees (Apis cerana). Nowadays, domestic honeybees (Apis mellifera) worldwide are also becoming infected due to globalization. Type C nosemosis can be asymptomatic or can cause important damage to bees, such as changes in temporal polyethism, energy and oxidative stress, immunity loss, and decreased average life expectancy. It causes drastic reductions in workers, numbers of broods, and honey production, finally leading to colony loss. Common treatment is based on fumagillin, an antibiotic with side effects and relatively poor efficiency, which is banned in the European Union. Natural products, probiotics, food supplements, nutraceuticals, and other veterinary drugs are currently under study and might represent alternative treatments. Prophylaxis and management of affected colonies are essential to control the disease. While N. ceranae is one potential cause of bee losses in a colony, other factors must also be considered, especially synergies between microsporidia and the use of insecticides.

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Section: Current Insights On Treatmentmentioning

confidence: 99%

The Role of Nosema ceranae (Microsporidia: Nosematidae) in Honey Bee Colony Losses and Current Insights on Treatment

Marín-García

Peyre

Ahuir-Baraja

et al. 2022

Veterinary Sciences

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“…In addition, this propolis extract treatment increased the trehalose levels and hypopharyngeal gland protein content in treated bees compared to an untreated control group ( Suwannapong et al, 2018 ). Dichloromethane extract of propolis from Upstate New York greatly reduced N. ceranae spore loads in a dose-dependent manner ( Burnham et al, 2020 ). A study in Italy that evaluated an ethanol extract of propolis from the honey bee A. mellifera demonstrated that treatment decreased the spore load of N. ceranae -infected worker bees ( Mura et al, 2020 ).…”

Section: Alternative Medicine For Treatment Of Microsporidiosismentioning

confidence: 99%

Current Therapy and Therapeutic Targets for Microsporidiosis

et al. 2022

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Microsporidia are obligate intracellular, spore-forming parasitic fungi which are grouped with the Cryptomycota. They are both opportunistic pathogens in humans and emerging veterinary pathogens. In humans, they cause chronic diarrhea in immune-compromised patients and infection is associated with increased mortality. Besides their role in pébrine in sericulture, which was described in 1865, the prevalence and severity of microsporidiosis in beekeeping and aquaculture has increased markedly in recent decades. Therapy for these pathogens in medicine, veterinary, and agriculture has become a recent focus of attention. Currently, there are only a few commercially available antimicrosporidial drugs. New therapeutic agents are needed for these infections and this is an active area of investigation. In this article we provide a comprehensive summary of the current as well as several promising new agents for the treatment of microsporidiosis including: albendazole, fumagillin, nikkomycin, orlistat, synthetic polyamines, and quinolones. Therapeutic targets which could be utilized for the design of new drugs are also discussed including: tubulin, type 2 methionine aminopeptidase, polyamines, chitin synthases, topoisomerase IV, triosephosphate isomerase, and lipase. We also summarize reports on the utility of complementary and alternative medicine strategies including herbal extracts, propolis, and probiotics. This review should help facilitate drug development for combating microsporidiosis.

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“…Many dietary supplements improve honey bee strength, immunity, and performance, thereby contributing to the maintenance of healthy colonies [8,15,19,[24][25][26][27][28]. Many studies investigated natural strategies against nosemosis, with plant and algal extracts as well as synthetic vitamin/mineral mixtures giving the best results [29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44]). These products, administrated to bees before or after the Nosema infection, significantly reduced mortality and infection rates [15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Potential of Wormwood and Oak Bark-Based Supplement in Health Improvement of Nosema ceranae-Infected Honey Bees

Glavinic,

Jovanovic,

Dominikovic

et al. 2024

Animals

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Nosema ceranae, a microsporidian parasite, as one of the stressors that contribute to honey bee decline, has a significant negative impact on the longevity, productivity, and reproductive capacity of honey bee colonies. There are several different strategies for Nosema infection control, including natural-based and antibiotic-based products. In this study, we tested wormwood and oak bark-based supplement “Medenko forte” on survival, Nosema infection, oxidative stress, and expression of immune-related genes in artificially N. ceranae-infected bees. The results revealed a positive influence on the survival of Nosema-infected bees, irrespectively of the moment of supplement application (day 1, day 3, or day 6 after bee emergence), as well as reduction of Nosema loads and, consequently, Nosema-induced oxidative stress. Supplementation had no negative effects on bee immunity, but better anti-Nosema than immune-stimulating effects were affirmed based on expression levels of abaecin, defensin, hymenoptaecin, apidaecin, and vitellogenin genes. In conclusion, the tested supplement “Medenko forte” has great potential in the health protection of Nosema-infected bees. However, further investigations need to be performed to elucidate its mechanisms of action.

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North American Propolis Extracts From Upstate New York Decrease Nosema ceranae (Microsporidia) Spore Levels in Honey Bees (Apis mellifera)

Cited by 8 publications

References 47 publications

The Role of Nosema ceranae (Microsporidia: Nosematidae) in Honey Bee Colony Losses and Current Insights on Treatment

The Role of Nosema ceranae (Microsporidia: Nosematidae) in Honey Bee Colony Losses and Current Insights on Treatment

Current Therapy and Therapeutic Targets for Microsporidiosis

Potential of Wormwood and Oak Bark-Based Supplement in Health Improvement of Nosema ceranae-Infected Honey Bees

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