Norwalk-like virus as a cause of a gastroenteritis outbreak in a childcare centre

Ferson, Mark J; Ressler, Kelly‐Anne; Mclver, Christopher J; Isaacs, Monica; Rawlinson, William D.

doi:10.1111/j.1467-842x.2000.tb01585.x

Cited by 2 publications

(2 citation statements)

References 5 publications

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“…Although NLV is commonly associated with gastroenteritis in older individuals [Caul, 1996], there is a growing literature linking NLV-related gastroenteritis to babies and children [Levett et al, 1996;Marshall et al, 1997;Matsuno et al, 1997;Steele et al, 1997;Parks et al, 1999;Farkas et al, 2000;Ferson et al, 2000;Pang et al, 2000]. The results of this study provide some of the most comprehensive information to date that NLV gastroenteritis is common in children in a community setting.…”

Section: Discussionmentioning

confidence: 71%

Incidence and characteristics of endemic Norwalk‐like virus‐associated gastroenteritis

Marshall

Hellard

Sinclair

et al. 2003

Journal of Medical Virology

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Endemic gastroenteritis associated with the Norwalk-like viruses (NLVs) is little understood. This study tested for NLV in gastroenteritis cases in 257 households in Melbourne, Australia, for the period September 1997 to February 1999 by a reverse transcription hemi-nested polymerase chain reaction. Positive samples were studied by nucleotide sequencing and phylogenetic analysis. NLV was detected in 73 (11.4%) of 638 faecal specimens tested. Twelve (1.9%) were NLV genogroup 1 (G1) and 61 (9.6%) NLV genogroup 2 (G2). Gastroenteritis symptoms associated with NLV G2/no other pathogens were significantly more severe than where no NLV was detected. NLV G1 and NLV G2 were detected in adults and children, males and females. NLV G2 incidence showed a marked seasonal periodicity with significant peaks in the Australian late spring/early summer periods. NLV G1 seasonality was significantly different from that of NLV G2. Seven major NLV clusters were identified by phylogenetic analysis.

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Section: Discussionmentioning

confidence: 71%

Incidence and characteristics of endemic Norwalk‐like virus‐associated gastroenteritis

Marshall

Hellard

Sinclair

et al. 2003

Journal of Medical Virology

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“…Thus norovirus-associated gastroenteritis outbreaks have been documented in a range of settings including child-minding centers, schools, camps, restaurants, hospitals, hostels, nursing homes, and cruise ships [Dedman et al, 1998;Fankhauser et al, 1998;Wright et al, 1998;Ferson et al, 2000;Green et al, 2001;Marshall et al, 2001;O'Donnell et al, 2001]. In this study the locations of the 30 norovirusassociated outbreaks were: hostels or nursing homes (27%), hospitals (13%), youth refuges (3%), related to food consumption or social gatherings (27%), school outings or camps (13%), and pre-school or child-minding centers (17%).…”

Section: Discussionmentioning

confidence: 99%

Molecular and epidemiological features of norovirus‐associated gastroenteritis outbreaks in Victoria, Australia in 2001

Marshall

Dimitriadis

Wright

2004

Journal of Medical Virology

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Norovirus was identified in 30 of 59 gastroenteritis outbreaks occurring in the state of Victoria, Australia in 2001 by RT-PCR and/or electron microscopy (EM). Norovirus outbreaks occurred in hostels/nursing homes (27%), hospitals (13%), youth refuges (3%), social gatherings associated with food consumption (27%), school outings/camps (13%), and pre-school/child-minding centers (17%). Norovirus outbreaks tended to occur in the warmer months. Phylogenetic analysis identified six clusters, one within genogroup 1 (G1) and five within genogroup 2 (G2). Cluster 1, which incorporates the G2 Camberwell/Lordsdale strains, was the most common (39% of outbreaks). In 2 of 27 outbreaks, strains from two G2 clusters, 1 and 5, occurred. Norovirus G2 was more common in the young and very old than in those in intermediate years. Norovirus G2 detection rate was higher in females than in males for adults (>15 years) and the susceptibility of adult females to norovirus G2 infection relative to males increased with age. In one outbreak analyzed, some sequences had a single base substitution, but this did not result in an amino acid (aa) change. The two most common norovirus clusters (G2 clusters 1 and 4) occurred in the capital of Victoria, Melbourne, and regional Victoria, but the least common clusters (G2 clusters 2 and 3 and G1 cluster 8) only occurred in inner Melbourne. Norovirus was occasionally detected by EM but not by RT-PCR. The occurrence of norovirus outbreaks is modulated by a large group of factors, which will have to be considered in any epidemiological model.

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Norwalk-like virus as a cause of a gastroenteritis outbreak in a childcare centre

Cited by 2 publications

References 5 publications

Incidence and characteristics of endemic Norwalk‐like virus‐associated gastroenteritis

Incidence and characteristics of endemic Norwalk‐like virus‐associated gastroenteritis

Molecular and epidemiological features of norovirus‐associated gastroenteritis outbreaks in Victoria, Australia in 2001

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