Nosocomial multi-drug resistant Acinetobacter baumannii bloodstream infection: risk factors and outcome with ampicillin-sulbactam treatment

Acinetobacter baumannii : A Brief Account of Mechanisms of Multidrug Resistance and Current and Future Therapeutic Management

“…The clinical improvement was also comparable with other system involvements like pneumonia and blood stream infections [18]. In blood stream infections caused by this strain, treatment with a combination of sulbactam and ampicillin was found to be statistically significant in reducing the mortality, which was seen in a study conducted in Israel in situations of multidrug resistance [19]. In meningitis, the combination was not found to be so beneficial.…”

Molecular Epidemiology of Sequential Outbreaks of Acinetobacter baumannii in an Intensive Care Unit Shows the Emergence of Carbapenem Resistance

“…Multidrug-resistant A. baumannii has increasingly been recognized as being responsible for large and sustained hospital outbreaks, particularly in ICU wards (4,6,7,10,15,16,24,29). Invasive diagnostic and therapeutic procedures used in hospital ICUs have been demonstrated to predispose subjects to severe infections with A. baumannii (4,6,15,24,29).…”

“…Acinetobacter baumannii is a glucose-nonfermentative gramnegative coccobacillus that is widely distributed in the hospital environment and is an important opportunistic pathogen responsible for a variety of nosocomial infections, comprising bacteremia, urinary tract infection, secondary meningitis, surgical-site infection, and nosocomial and ventilator-associated pneumonia, especially in intensive-care-unit (ICU) patients (4,6,7,10,15,16,24,29). Extensive use of antimicrobial chemotherapy within hospitals has contributed to the emergence and increase in the number of A. baumannii strains resistant to a wide range of antibiotics, including broad-spectrum beta-lactams, aminoglycosides, and fluoroquinolones (4,7,10,15,24,28).…”

“…Extensive use of antimicrobial chemotherapy within hospitals has contributed to the emergence and increase in the number of A. baumannii strains resistant to a wide range of antibiotics, including broad-spectrum beta-lactams, aminoglycosides, and fluoroquinolones (4,7,10,15,24,28). In recent years, several outbreaks of nosocomial infections caused by carbapenem-resistant A. baumannii have been documented (3,6,10,16,25).…”

Invasive Device-Related Nosocomial Infection Surveillance in Intensive Care Unit

“…15,16 Kliniğimizde tespit edilen enfeksiyon etkenlerine bakıldığında en sık görülen İAİHE etkeni Acinetobacter sp.'dir. Ülkemizde de hem yoğun bakım hastalarından izole edilen izolatlarla yapılan çok merkezli çalışmalarda hem de bölgesel çalışmalarda giderek artan antibiyotik dirençleri gösterilmiştir.…”