Not all women diagnosed with PCOS share the same cardiovascular risk profiles

Jovanovic, Vuk; Carmina, Enrico; Løbo, Rogerio A.

doi:10.1016/j.fertnstert.2009.04.021

Cited by 58 publications

(41 citation statements)

References 75 publications

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“…According to the AE-PCOS Society consensus statement (12), ovulatory PCOS patients have a lower BMI, lesser degrees of hyperandrogenism and hyperinsulinemia, reduced metabolic syndrome prevalence, and milder forms of dyslipidemia whereas non-hyperandrogenic PCOS patients have the most metabolically favorable profile, often indistinguishable from normal women. While those with ovulatory PCOS appear to have less instances of increased CVR, it is still greater than in normal controls (9,10,11). In a recent systematic review and meta-analysis, there was a twofold risk of arterial disease for patients with PCOS relative to women without PCOS (13).…”

Section: Pcos Phenotypesmentioning

confidence: 99%

Section: Pcos Phenotypesmentioning

confidence: 99%

“…Of the four phenotypes possible within the spectrum of PCOS based on the Rotterdam criteria, the phenotype without hyperandrogenism (only oligomenorrhea and polycystic ovaries) has been controversial (9). The classical phenotype of oligomenorrhea, hyperandrogenism, and polycystic ovaries in comparison with the other subtypes has higher BMI due to greater general and central obesity, more severe insulin resistance (IR) and a higher prevalence of dyslipidemia and other CVR markers (2,9,10,11). According to the AE-PCOS Society consensus statement (12), ovulatory PCOS patients have a lower BMI, lesser degrees of hyperandrogenism and hyperinsulinemia, reduced metabolic syndrome prevalence, and milder forms of dyslipidemia whereas non-hyperandrogenic PCOS patients have the most metabolically favorable profile, often indistinguishable from normal women.…”

Section: Pcos Phenotypesmentioning

confidence: 99%

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MECHANISMS IN ENDOCRINOLOGY: Recent advances in cardiovascular aspects of polycystic ovary syndrome

Sathyapalan

Atkin²

2012

European Journal of Endocrinology

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Polycystic ovary syndrome (PCOS) has been associated with increased cardiovascular risk (CVR) markers, but population studies have not clarified whether there is an increase in cardiovascular morbidity and mortality. Four different PCOS phenotypes resulted from the Rotterdam criteria that may differ in their CVR potential, thus introducing further complexity. This has led to studies using surrogate CVR markers including biomarkers in blood and imaging such as flow-mediated vasodilatation. In PCOS, both peripheral and central insulin resistance (IR) have been shown. Weight loss has been shown to improve IR and visceral fat, while insulin sensitizer therapies with metformin or thiazolidinediones improve IR and endothelial dysfunction. IR is also found in non-alcoholic fatty liver disease that in turn is very common in PCOS; studies have suggested that IR may be improved by treatment with metformin and omega-3 fish oils. PCOS patients have a more dyslipidemic phenotype that is worse in 'classical PCOS' associated with a higher CVR. Studies with atorvastatin and simvastatin have reported a decrease in the lipid parameters and an improvement in CVR indices including IR, but it is unclear whether this is due to their lipid-lowering action or a pleiotropic effect of the statin. In this expert opinion review, the relevant literature published during the last 2 years was considered. It focuses on some recent important data that has emerged while also exposing the gaps that remain in our knowledge that need to be addressed.

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Section: Pcos Phenotypesmentioning

confidence: 99%

Section: Pcos Phenotypesmentioning

confidence: 99%

Section: Pcos Phenotypesmentioning

confidence: 99%

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MECHANISMS IN ENDOCRINOLOGY: Recent advances in cardiovascular aspects of polycystic ovary syndrome

Sathyapalan

Atkin²

2012

European Journal of Endocrinology

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“…There is some evidence that the prevalence of cardiometabolic risk factors may vary by PCOS phenotypes [160] ; however, studies addressing non-traditional cardiometabolic risk factors across these phenotypes are limited and significantly confounded by the impact of adiposity.…”

Section: Impact Of Pcos Phenotypes On Cardiometabolic Risk Factorsmentioning

confidence: 99%

Cardiometabolic Risks in Polycystic Ovary Syndrome: Non-Traditional Risk Factors and the Impact of Obesity

et al. 2016

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Polycystic ovary syndrome (PCOS) is a common and complex endocrinopathy with reproductive, metabolic, and psychological features and significantly increased cardiometabolic risks. PCOS is underpinned by inherent insulin resistance and hyperandrogenism. Obesity, more common in PCOS, plays an important role in the pathophysiology, exacerbating hyperinsulinaemia and hyperandrogenism, leading to recommended first-line lifestyle intervention. Significant traditional and non-traditional risk factors are implicated in PCOS in addition to obesity-exacerbated cardiometabolic risks and are explored in this review to promote the understanding of this common metabolic and reproductive condition.

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“…[41] proved that the more the PCOS phenotype is complete the more the cardiovascular risk markers are present.…”

Section: Classical Cardiovascular Risk Factorsmentioning

confidence: 99%

Long term complications of polycystic ovary syndrome (PCOS)

Peigné

Dewailly

2014

Annales d'Endocrinologie

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Not all women diagnosed with PCOS share the same cardiovascular risk profiles

Cited by 58 publications

References 75 publications

MECHANISMS IN ENDOCRINOLOGY: Recent advances in cardiovascular aspects of polycystic ovary syndrome

MECHANISMS IN ENDOCRINOLOGY: Recent advances in cardiovascular aspects of polycystic ovary syndrome

Cardiometabolic Risks in Polycystic Ovary Syndrome: Non-Traditional Risk Factors and the Impact of Obesity

Long term complications of polycystic ovary syndrome (PCOS)

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