Not in the Same Vein: Inflammatory Bowel Disease, Malignancy, and Enterocolic Lymphocytic Phlebitis

Farber, Orly N; Weingarden, Alexa R.; Lee, Christopher; Braxton, David R.; Bingham, David; Scott, Gregory D.; Fernandez‐Becker, Nielsen; Goff, Daniel; Shelton, Andrew; Kin, Cindy

doi:10.1007/s10620-020-06425-w

Cited by 3 publications

(1 citation statement)

References 11 publications

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“…Gastrointestinal symptoms such as abdominal pain, nausea and vomiting, diarrhea, and gastrointestinal bleeding have been reported in some cases [5][6][7][8][9][10][11][12][13]. The small and large intestines are the most common sites of diagnosis [1,9,14], and the disease may resemble ischemic or inflammatory bowel disease (IBD) [6,7]. However, due to the lack of disease-specific endoscopic or imaging findings [1], the diagnosis is made postoperatively, not preoperatively.…”

Section: Introductionmentioning

confidence: 99%

Enterocolic Lymphocytic Phlebitis Treated Preoperatively with Biologics and Immunosuppressive Agents

Okano

Yao

Nomura

et al. 2022

Case Reports in Pathology

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Enterocolic lymphocytic phlebitis is phlebitis of unknown etiology in which lymphocytes affect veins without arteries and shows evidence of systemic vasculitis in the intestinal wall and mesentery, mainly in the small intestine and colon. Although patients present with a variety of gastrointestinal symptoms and findings like those of inflammatory bowel disease or ischemic bowel disease, there are no specific findings for enterocolic lymphocytic phlebitis. As a result, a diagnosis tends to be made after surgery. There are few case reports of enterocolic lymphocytic phlebitis, and the impact of chronic courses and immunosuppressive drugs on enterocolic lymphocytic phlebitis is not well known. A 47-year-old man was treated with infliximab and steroids for unexplained ulceration and narrowing of the ileocecal area, which was suspected to be inflammatory bowel disease with atypical findings. Lymphocytic phlebitis was noted in the surgical specimen, and enterocolic lymphocytic phlebitis was diagnosed. No recurrence of enterocolic lymphocytic phlebitis was observed postoperatively. This disease should also be considered among patients with inflammatory bowel disease-like lesions that do not respond to infliximab or steroids.

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Section: Introductionmentioning

confidence: 99%

Enterocolic Lymphocytic Phlebitis Treated Preoperatively with Biologics and Immunosuppressive Agents

Okano

Yao

Nomura

et al. 2022

Case Reports in Pathology

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An Unexpected Cause of Fistulizing Small Intestinal Disease

Dilmaghani,

Graham,

Sweetser

2024

Gastroenterology

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Enterocolic Lymphocytic Phlebitis Masquerading as a Malignant Stricture in the Caecum: A Case Report and Literature Review

Agrawal,

Narayanasamy

et al. 2024

Cureus

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Enterocolic lymphocytic phlebitis (ELP) is an idiopathic form of venous inflammation that is limited to the gastrointestinal tract. It is characterised by inflammation of the veins with no involvement of the arteries. Usually, it presents with gastrointestinal symptoms such as abdominal pain, and imaging may suggest malignancy. The reported case is a 56-year-old female presented with rectal bleeding, abdominal pain and diarrhoea. All blood test results were normal; however, she had an elevated C-reactive protein (CRP) level. Computed tomography colonography showed caecal wall thickening, suggesting caecal malignancy. Following a multidisciplinary discussion, the patient had a right hemicolectomy, and the histology showed no malignancy and typical features of ELP. This is a rare idiopathic form of venous inflammation localised to the gastrointestinal tract, which can occasionally present similarly to bowel malignancy. ELP most commonly presents with abdominal pain, followed by hematochezia and diarrhaea. The duration of symptoms varies widely, from hours to a year. Diagnosis is usually confirmed by histopathological assessment. We present this case and literature review considering its rarity, which adds to the literature on this condition.

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Not in the Same Vein: Inflammatory Bowel Disease, Malignancy, and Enterocolic Lymphocytic Phlebitis

Cited by 3 publications

References 11 publications

Enterocolic Lymphocytic Phlebitis Treated Preoperatively with Biologics and Immunosuppressive Agents

Enterocolic Lymphocytic Phlebitis Treated Preoperatively with Biologics and Immunosuppressive Agents

An Unexpected Cause of Fistulizing Small Intestinal Disease

Enterocolic Lymphocytic Phlebitis Masquerading as a Malignant Stricture in the Caecum: A Case Report and Literature Review

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