Not just a fluke: Expanding the organ supply

Kotton, Camille N.; Hurtado, Rocio

doi:10.1002/lt.22178

Cited by 3 publications

(3 citation statements)

References 12 publications

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“…To date, only 20 cases of transplanted liver grafts infested with C. sinensis (Table ) and 7 with S. mansoni have been reported in the literature . All the liver transplantations with grafts infested with C. sinensis (18 in adult and 2 in pediatric recipients) were performed in East Asian countries, 16 of which were deceased‐donor living transplantation and 5 LDLT.…”

Section: Discussionmentioning

confidence: 99%

“…In North America, the prevalence of C. sinensis in the many Chinese immigrants was estimated at 15.5% . In China alone, it is estimated that prevalence has tripled in the last decade . O. viverrini is concentrated in Southeast Asia.…”

Section: Discussionmentioning

confidence: 99%

“…Infested hosts may remain asymptomatic for decades and consequently their liver can become available as a graft. Twenty liver transplantations with C. sinensis-infested grafts are reported in the literature (3)(4)(5)(6)(7)(8)(9). All of them occurred in Asian countries.…”

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confidence: 99%

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Liver fluke‐infested graft used for living‐donor liver transplantation: case report and review of the literature

Capobianco¹,

Frank

Königsrainer³

et al. 2015

Transplant Infectious Dis

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Clonorchiasis is a cholangiopathy caused by foodborne trematode parasites, also known as liver flukes. Clonorchiasis is endemic in a wide geographical area extending from Eastern Europe to Southeast Asia. Infested hosts may remain asymptomatic for decades and consequently their liver can become available as a graft. To date, 20 liver transplantations with liver fluke-infested grafts have been reported in the literature. All of them occurred in Asian countries. We, here, report the first case to our knowledge in the Western world of living-donor liver transplantation (LDLT) with an Opisthorchis felineus-infested graft, and present a review of the literature. A 6-month-old girl with decompensated secondary biliary cirrhosis underwent an LDLT with a left lateral graft infested with O. felineus. After prompt diagnosis and adequate therapy, both donor and recipient had an uneventful postoperative course and long-term follow-up. Liver grafts infested with liver flukes do not pose a contraindication to liver donation from deceased or living donors, provided that a correct diagnosis and treatment are performed in a timely fashion.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Liver fluke‐infested graft used for living‐donor liver transplantation: case report and review of the literature

Capobianco¹,

Frank

Königsrainer³

et al. 2015

Transplant Infectious Dis

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Current World Literature

2011

Current Opinion in Organ Transplantation

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Clonorchiasis and opisthorchiasis: epidemiology, transmission, clinical features, morbidity, diagnosis, treatment, and control

Qian,

Keiser,

Utzinger

et al. 2024

Clin Microbiol Rev

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SUMMARY Clonorchis sinensis , Opisthorchis viverrini , and Opisthorchis felineus are important liver flukes that cause a considerable public health burden in eastern Asia, southeastern Asia, and eastern Europe, respectively. The life cycles are complex, involving humans, animal reservoirs, and two kinds of intermediate hosts. An interplay of biological, cultural, ecological, economic, and social factors drives transmission. Chronic infections are associated with liver and biliary complications, most importantly cholangiocarcinoma. With regard to diagnosis, stool microscopy is widely used in epidemiologic surveys and for individual diagnosis. Immunologic techniques are employed for screening purposes, and molecular techniques facilitate species differentiation in reference laboratories. The mainstay of control is preventive chemotherapy with praziquantel, usually combined with behavioral change through information, education and communication, and environmental control. Tribendimidine, a drug registered in the People’s Republic of China for soil-transmitted helminth infections, shows potential against both C. sinensis and O. viverrini and, hence, warrants further clinical development. Novel control approaches include fish vaccine and biological control. Considerable advances have been made using multi-omics which may trigger the development of new interventions. Pressing research needs include mapping the current distribution, disentangling the transmission, accurately estimating the disease burden, and developing new diagnostic and treatment tools, which would aid to optimize control and elimination measures.

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Not just a fluke: Expanding the organ supply

Cited by 3 publications

References 12 publications

Liver fluke‐infested graft used for living‐donor liver transplantation: case report and review of the literature

Liver fluke‐infested graft used for living‐donor liver transplantation: case report and review of the literature

Current World Literature

Clonorchiasis and opisthorchiasis: epidemiology, transmission, clinical features, morbidity, diagnosis, treatment, and control

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