Not just skin deep: A case report of multiple endocrine neoplasia type 1

Simi, SM; Narayanan, Beena; Nandakumar, G

doi:10.4103/0019-5154.97679

Cited by 7 publications

(11 citation statements)

References 8 publications

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“…3,6,11 It has been suggested that the angiofibromas of Wermer syndrome differ from those associated with tuberous sclerosis in that they are smaller, fewer in number, and concentrated on the upper lip and vermilion border. 3,11,12 The genetic aberrations in the two types are clearly different, with MEN-1 angiofibromas exhibiting loss of MEN-1 gene function whereas tuberous sclerosis angiofibromas stem from dysfunction in one of the TS genes. 13 Multiple facial angiofibromas have also been reported as an early manifestation of Birt-Hogg-Dubé syndrome.…”

Section: Discussion Follows On Page 792mentioning

confidence: 99%

“…Several reports about the association between cutaneous lesions (especially angiofibromas and collagenomas) and MEN1 have been published, with the initial observation coming from Darling et al in 1997 . These cutaneous lesions often appear at the first phases of the syndrome and in some cases have facilitated an early diagnosis of MEN1 before internal tumors were detected . Multiple facial angiofibromas are most often associated with tuberous sclerosis, but have been reported in nearly 90% of MEN1 patients .…”

mentioning

confidence: 99%

“…These cutaneous lesions often appear at the first phases of the syndrome and in some cases have facilitated an early diagnosis of MEN1 before internal tumors were detected . Multiple facial angiofibromas are most often associated with tuberous sclerosis, but have been reported in nearly 90% of MEN1 patients . It has been suggested that the angiofibromas of Wermer syndrome differ from those associated with tuberous sclerosis in that they are smaller, fewer in number, and concentrated on the upper lip and vermilion border .…”

mentioning

confidence: 99%

“…Multiple facial angiofibromas are most often associated with tuberous sclerosis, but have been reported in nearly 90% of MEN1 patients . It has been suggested that the angiofibromas of Wermer syndrome differ from those associated with tuberous sclerosis in that they are smaller, fewer in number, and concentrated on the upper lip and vermilion border . The genetic aberrations in the two types are clearly different, with MEN‐1 angiofibromas exhibiting loss of MEN‐1 gene function whereas tuberous sclerosis angiofibromas stem from dysfunction in one of the TS genes .…”

mentioning

confidence: 99%

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Multiple cutaneous collagenomas in the setting of multiple endocrine neoplasia type 1

Pérez

North

2015

J Cutan Pathol

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Section: Discussion Follows On Page 792mentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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confidence: 99%

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Multiple cutaneous collagenomas in the setting of multiple endocrine neoplasia type 1

Pérez

North

2015

J Cutan Pathol

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“…Notably, café-au-lait macules were seen in 38% of the patients; however, they were not considered to be diagnostically significant [14]. Other manifestations included confetti-like hypopigmented macules (6%) and gingival papules (6%) [15].…”

Section: Skin Manifestationsmentioning

confidence: 96%

Dermatologic Manifestations of Endocrine Disorders

Raj¹,

Elshimy²,

Mishra³

et al. 2021

Cureus

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Endocrine disorders are known to involve all organ systems of the body, including the skin. The cutaneous manifestations of endocrine disorders can range from common findings such as acanthosis nigricans, pretibial myxedema, acne, hirsutism, hyper or hypopigmentation to rare cutaneous findings such as miliaria rubra, calciphylaxis, lentigines, and calcinosis cutis. These cutaneous symptoms can sometimes be the presenting symptoms or can even be pathognomonic of the underlying endocrine condition. In some cases, the cutaneous symptoms from an underlying endocrine abnormality may be the most prominent. These symptoms can significantly affect the quality of life of individuals. Often, individuals may seek health care from a dermatologist or primary care physician for isolated skin symptoms. Therefore, it is imperative for physicians to recognize the skin symptoms as the manifestation of the endocrine disorder for prompt diagnosis and treatment of the underlying endocrine disorder.

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Cutaneous manifestations of endocrine diseases and their assessment in reconstructive surgery

Khodova,

Torchinova,

Gagloeva

et al. 2024

BIO Web Conf.

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The skin is the largest organ of the human body, and its main function is protection from external injuries and infectious influences. It is a metabolically active organ that works mainly by self-renewal of the squamous epithelium through continuous differentiation. The surface layer of the skin “epidermis” is updated every four weeks. It is also the body’s largest sensory organ, which can respond to external stimuli such as heat, cold, touch and pressure, which is necessary to maintain the body’s thermostat. Being the largest organ of the body, the skin is an active immune organ and an important peripheral neuro-endocrine organ. It is closely related to the endocrine system and, therefore, contributes to the homeostasis of peripheral hormones. A complex pathophysiology occurs when thyroid hormones are exposed to the skin, especially in the case of a continuing apparent violation of the regulation of thyroid hormones. Thyroid hormone is considered one of the key hormones regulating skin homeostasis. The release of peripheral thyroid hormones (T4 and T3) affects many organs, additionally regulating various functions at the cellular level. In particular, the skin is considered an important target organ, on which the thyroid hormone has a significant effect. Numerous skin diseases are associated with a violation of the regulation of thyroid hormones. Rough skin manifestations are usually the first sign of an imbalance of thyroid hormones, in which they play an integral role in maintaining natural function. This article reviews the pathology of thyroid hormones, as well as skin diseases associated with diseases of the pancreas. The interaction of thyroid gland diseases with the skin, manifested in the form of various skin pathologies, will be considered. It is known that endocrine disorders affect all organ systems of the body, including the skin.

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Not just skin deep: A case report of multiple endocrine neoplasia type 1

Cited by 7 publications

References 8 publications

Multiple cutaneous collagenomas in the setting of multiple endocrine neoplasia type 1

Multiple cutaneous collagenomas in the setting of multiple endocrine neoplasia type 1

Dermatologic Manifestations of Endocrine Disorders

Cutaneous manifestations of endocrine diseases and their assessment in reconstructive surgery

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