Not only accumulation, but also saturation status of intramuscular lipids is significantly affected by PPARγ activation

Chabowski, Adrian; Żendzian-Piotrowska, Małgorzata; Nawrocki, Artur; Górski, Jan

doi:10.1111/j.1748-1716.2011.02380.x

Cited by 29 publications

(35 citation statements)

References 58 publications

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“…Furthermore, the primary function of PGZ is to increase the IMF deposition, and improvement of the meat flavor and taste has already been proven in pigs . Intensive research has ascribed the mechanism to the role of PGZ as an affinity ligand of PPAR γ , promoting adipocyte proliferation and fat accumulation . Undoubtedly, we found that supplementation with 7.5 mg kg −1 PGZ and 15 mg kg −1 PGZ increased the IMF by 14.14% and 20.37%, respectively.…”

Section: Discussionmentioning

confidence: 64%

Dietary supplementation with pioglitazone hydrochloride improves intramuscular fat, fatty acid profile, and antioxidant ability of thigh muscle in yellow‐feathered chickens

et al. 2019

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BACKGROUND Muscle fat content and fatty acid composition play an important role in poultry flavor and taste. To investigate the effects of pioglitazone hydrochloride (PGZ) on growth performance and thigh muscle quality in yellow‐feathered chickens, 360 female chickens were randomly divided into three groups and treated with three doses of PGZ (0, 7.5, and 15 mg kg−1) for 28 days. Each group had six replicates of 20 chickens. RESULTS The results showed that dietary supplementation with 15 mg kg−1 PGZ increased average daily feed intake (ADFI) and the average daily gain (ADG) from 0 to 14 days. Furthermore, the triglyceride (TG) level was decreased by 15 mg kg−1 PGZ, whereas the eviscerated yield was increased. The relative weight of the heart and kidneys showed a linear increase with dietary PGZ supplementation, and the drip loss of the thigh muscle was significantly decreased by 15 mg kg−1 PGZ supplementation. Moreover, a* value, intramuscular fat (IMF), and polyunsaturated fatty acids (PUFAs) showed a linear increase, and pH24 h and drip loss showed a quadratic influence with the levels of PGZ supplementation. In particular, the PUFA proportion was increased by 7.63% and 9.14% in the 7.5 mg kg−1 PGZ and 15 mg kg−1 PGZ groups, respectively. Additionally, 15 mg kg−1 of PGZ increased the total antioxidant capacity (T‐AOC) and glutathione peroxidase (GSH‐PX) activity. CONCLUSION In summary, 15 mg kg−1 PGZ has substantial effects on growth performance and meat quality, particularly by decreasing drip loss and increasing IMF content, PUFA proportions, and antioxidant ability. © 2019 Society of Chemical Industry

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Section: Discussionmentioning

confidence: 64%

Dietary supplementation with pioglitazone hydrochloride improves intramuscular fat, fatty acid profile, and antioxidant ability of thigh muscle in yellow‐feathered chickens

et al. 2019

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“…Interestingly, some of these studies suggested also that, not only DGs accumulation may affect insulin signalling but along with increased saturation status of FA present in this fraction is deleterious (Chabowski et al . ). However, there is still a matter of debate whether saturation status of FA species present in intracellular lipid fraction influences insulin signalling (Wakelam ).…”

Section: Discussionmentioning

confidence: 97%

Fatty acid transporters involved in the palmitate and oleate induced insulin resistance in primary rat hepatocytes

et al. 2012

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“…Although baseline expression of muscle PLIN5 is strongly reduced in PPARα knockout mice, HFD-mediated up-regulation of PLIN5 is not prevented as well in these transgenic mice23. It is still unclear how HFD promotes the up-regulation of muscle PLIN5 but this may be under the control of PPARγ which contribute to lipid accumulation in skeletal muscle during high fat feeding36. Other transcription factors related to lipid storage may be involved.…”

Section: Discussionmentioning

confidence: 99%

Perilipin 5 fine-tunes lipid oxidation to metabolic demand and protects against lipotoxicity in skeletal muscle

Laurens

Bourlier

Mairal

et al. 2016

Sci Rep

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Lipid droplets (LD) play a central role in lipid homeostasis by controlling transient fatty acid (FA) storage and release from triacylglycerols stores, while preventing high levels of cellular toxic lipids. This crucial function in oxidative tissues is altered in obesity and type 2 diabetes. Perilipin 5 (PLIN5) is a LD protein whose mechanistic and causal link with lipotoxicity and insulin resistance has raised controversies. We investigated here the physiological role of PLIN5 in skeletal muscle upon various metabolic challenges. We show that PLIN5 protein is elevated in endurance-trained (ET) subjects and correlates with muscle oxidative capacity and whole-body insulin sensitivity. When overexpressed in human skeletal muscle cells to recapitulate the ET phenotype, PLIN5 diminishes lipolysis and FA oxidation under basal condition, but paradoxically enhances FA oxidation during forskolin- and contraction- mediated lipolysis. Moreover, PLIN5 partly protects muscle cells against lipid-induced lipotoxicity. In addition, we demonstrate that down-regulation of PLIN5 in skeletal muscle inhibits insulin-mediated glucose uptake under normal chow feeding condition, while paradoxically improving insulin sensitivity upon high-fat feeding. These data highlight a key role of PLIN5 in LD function, first by finely adjusting LD FA supply to mitochondrial oxidation, and second acting as a protective factor against lipotoxicity in skeletal muscle.

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Not only accumulation, but also saturation status of intramuscular lipids is significantly affected by PPARγ activation

Abstract: These findings support the conclusion that not only the change in total lipid content (DAG and TAG), but also FA composition is affected by rosiglitazone in an animal model of high-fat-diet-induced insulin resistance.

Cited by 29 publications

References 58 publications

Dietary supplementation with pioglitazone hydrochloride improves intramuscular fat, fatty acid profile, and antioxidant ability of thigh muscle in yellow‐feathered chickens

Dietary supplementation with pioglitazone hydrochloride improves intramuscular fat, fatty acid profile, and antioxidant ability of thigh muscle in yellow‐feathered chickens

Fatty acid transporters involved in the palmitate and oleate induced insulin resistance in primary rat hepatocytes

Perilipin 5 fine-tunes lipid oxidation to metabolic demand and protects against lipotoxicity in skeletal muscle

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