Notalgia paresthesica successfully treated with narrow‐band UVB: report of five cases

Pérez-Pérez, L.; Allegue, F.; Jm, Fabeiro; Jl, Caeiro; Zulaica, Á.

doi:10.1111/j.1468-3083.2009.03479.x

Cited by 31 publications

(19 citation statements)

References 7 publications

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“…The use of UVB was explored with five patients receiving a three times per week protocol, showing promising reduction in pruritus for all patients. Considering its extensive use in multiple other dermatoses, UVB would be useful for those nonresponsive to other therapies with compliance mainly limiting its use . In another single case report, surgical decompression of a paraspinal nerve resolved NP symptoms completely; however, the highly invasive nature of the procedure and risks associated restrict its use …”

Section: Discussionmentioning

confidence: 99%

Notalgia paresthetica: a review for dermatologists

Howard

Sahhar

Andrews³

et al. 2017

Int J Dermatology

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Notalgia paresthetica (NP) is an underdiagnosed condition that presents with unilateral pruritus medial to the scapula on the midback with or without an associated hyperpigmented or hypopigmented macule. There is a paucity of recent reviews on this chronic cutaneous neuropathy in peer-reviewed journals. Current theories propose the condition is likely multifactorial, including spinal entrapment and muscular compressive neuropathy. An extensive literature review was performed by searching the MEDLINE database to review all published works on notalgia paresthetica. This review will provide a useful update for clinicians on the pathogenesis, clinical features, biopsy features, risk factors, and management options for this condition including pharmacological and nonpharmacological methods detailing published treatment options to date for this difficult to treat condition.

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Section: Discussionmentioning

confidence: 99%

Notalgia paresthetica: a review for dermatologists

Howard

Sahhar

Andrews³

et al. 2017

Int J Dermatology

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“…Topical capsaicin is the most widely used medication among dermatologists. Transcutaneous electrical nerve stimulation, treatment with gabapentin, oxcarbazepine, and botulinum toxin, and exposure to narrow-band ultraviolet-B radiation have recently shown promising results6. However, in most cases, various treatment efforts have been disappointing.…”

Section: Discussionmentioning

confidence: 99%

Neuropathic Itch of the Back: A Case of Notalgia Paresthetica

Shin

Kim

2014

Ann Dermatol

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Notalgia paresthetica refers to an isolated mononeuropathy involving chronic localized itch or paresthesia most often at the skin of the scapula or surrounding regions. There are no specific skin manifestations except those arising from chronic scratching and rubbing. The specific etiology remains unknown; however, it has been theorized that the neuropathic itch is caused by sensory nerve entrapment involving the posterior rami of the T2 to T6 nerve root. The entrapment is due to degenerative changes in the vertebrae. We report here a particular case of notalgia paresthetica in a 55-year-old woman. The patient visited our hospital for tingling pain around the left inferior angle of the scapula. Pruritus was first reported seven years ago with tingling pain developing only four months ago. There were no specific skin lesions observed except for excoriation and vague hyperpigmentation. A skin biopsy revealed only epidermal thinning with pigmentary incontinence. The patient was treated with 600 mg of gabapentin daily as well as capsaicin cream. The response was deemed unsatisfactory.

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“…15 Oral medications include oxcarbazepine, 16 gabapentin 17,18 and amitriptyline. 19 Other therapies documented include TENS, 20 EMS, 21 Narrow band UV-B, 22 osteopathic manipulation, 23 acupuncture, 24 exercise 25 and physiotherapy. 3 Paravertebral nerve blocks, 26 intravenous lidocaine infusions 27 and surgical decompression 28 have also been described.…”

Section: Discussionmentioning

confidence: 99%

<p>Eastern Pain Association Annual Meeting 2019 Abstract Session Award Winners</p>

Gharibo¹,

Nicholas²,

Ohara³

et al. 2020

JPR

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Neuropathic pain is defined as pain caused by a lesion or disease of the somatosensory system. This debilitating illness affects roughly 7 percent of the population in the United States. Microglia, important immune cells in the central nervous system, are shown to play a critical role in the development of neuropathic pain. Peripheral nerve injury can activate spinal cord microglia to become pro-inflammatory versus anti-inflammatory phenotypes. CD137 ligand is a receptor on microglia that binds to the CD137 receptor on T lymphocytes. We have shown that CD137L knockout (KO) mice display reduced sensory sensitivity and faster functional recovery following sciatic nerve crush (SNC). We hypothesize that CD137L depletion induces this change through promoting microglia to preferentially differentiate into an anti-inflammatory subtype after SNC. Methods: To test this hypothesis, qRT-PCR and Flow Cytometry were used to measure the expression of markers specific to pro-vs anti-inflammatory microglia at various times following SNC in both wild-type (WT) and CD137L KO mice.

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Notalgia paresthesica successfully treated with narrow‐band UVB: report of five cases

Abstract: Given the benefits achieved, we stress the interest of UVB narrow-band as a safe and well tolerated alternative treatment for notalgia paresthetica.

Cited by 31 publications

References 7 publications

Notalgia paresthetica: a review for dermatologists

Notalgia paresthetica: a review for dermatologists

Neuropathic Itch of the Back: A Case of Notalgia Paresthetica

<p>Eastern Pain Association Annual Meeting 2019 Abstract Session Award Winners</p>

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