2022
DOI: 10.1186/s12935-022-02736-2
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Notch-associated lncRNAs profiling circuiting epigenetic modification in colorectal cancer

Abstract: Background Colorectal cancer (CRC) is one of the most prevalent digestive cancers, ranking the 2nd cause of cancer-related fatality worldwide. The worldwide burden of CRC is predicted to rise by 60% by 2030. Environmental factors drive, first, inflammation and hence, cancer incidence increase. Main The Notch-signaling system is an evolutionarily conserved cascade, has role in the biological normal developmental processes as well as malignancies. Lo… Show more

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Cited by 42 publications
(8 citation statements)
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“…Nineteen lncRNAs were identified that were differentially expressed between active UC and controls in at least three datasets of the nine GEO datasets. Of these nineteen lncRNAs, miR-215, FOXD2-AS1, SATB2-AS1, TP53TG1, LINC01224, CRNDE, and DPP10-AS1 have been implicated in colorectal cancer (CRC) [42][43][44][45][46][47][48]. The higher expression of these lncRNAs may be associated with promoting colorectal cancer (CRC) through regulating gene expression, epithelial to mesenchymal transition (EMT), cell cycle progression, and by promoting tumor proliferation, invasion, and migration.…”
Section: Discussionmentioning
confidence: 99%
“…Nineteen lncRNAs were identified that were differentially expressed between active UC and controls in at least three datasets of the nine GEO datasets. Of these nineteen lncRNAs, miR-215, FOXD2-AS1, SATB2-AS1, TP53TG1, LINC01224, CRNDE, and DPP10-AS1 have been implicated in colorectal cancer (CRC) [42][43][44][45][46][47][48]. The higher expression of these lncRNAs may be associated with promoting colorectal cancer (CRC) through regulating gene expression, epithelial to mesenchymal transition (EMT), cell cycle progression, and by promoting tumor proliferation, invasion, and migration.…”
Section: Discussionmentioning
confidence: 99%
“…In addition, BCL2L11 also plays a major role in immune tolerance in UC [ 45 ]. CYTOR plays a role in promoting inflammation and epithelial–mesenchymal transition, ultimately promoting cellular invasion and CRC progression [ 46 ]. The expression of lncRNA CYTOR is correlated with the expression of FABP1, which is involved in the intestinal absorption of dietary long-chain fatty acids [ 47 ].…”
Section: Discussionmentioning
confidence: 99%
“…These lncRNAs included snaR and BACE1AS. Further evidence that snaR contributes to 5-FU resistance in colon cancer cells comes from the fact that inhibiting snaR makes cells more sensitive to the drug 5-FU [ 179 ]. ANRIL, one of onco-lncRNAs, was substantially expressed in the tissues and 5-FU-resistant GC cells BGC823/5-FU.…”
Section: Introductionmentioning
confidence: 99%