Novalis Tx radiosurgical platform experience in National Medical Research Centre for Oncology of the Ministry of Health of Russian

Вошедский, В. И.; Sakun, Pavel G.; Gusareva, Marina A.; Vlasov, S. G.; Мусейко, Ксения Николаевна; Komandirov, M. A.; Култышева, Ю. А.

doi:10.37748/2687-0533-2020-1-4-4

Cited by 3 publications

(1 citation statement)

References 7 publications

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“…Неотъемлемой частью комплексного лечения генерализованных больных с НМРЛ является стереотаксическая радиохирургия (SRS), которая продемонстрировала свою высокую эффективность при лечении больных с метастатическим поражением головного мозга [18]. Большие дозы ионизирующего излучения при SBRT обладают более мощным биологическим воздействием и приводят к высоким показателям местного контроля опухоли.…”

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Molecular alterations in the culture of lung cancer cells H1299 after exposure to high doses of ionizing radiation

Voshedskiy¹,

Sakun²,

Genkova³

et al. 2021

Innovacionnaâ medicina Kubani

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Objective To study the copy number of genes-components of signaling cascades involved in DNA repair, cell cycle regulation and apoptosis under the influence of high doses of ionizing radiation.Material and Мethods The study was carried out on a culture of H1299 non-small cell lung cancer cells. Cell lines were cultured in a Binder incubator (Germany) for 24 h (at 37 °C, 5% CO2 ), and then the groups were divided into therapeutic and control. The first one was irradiated with a NovalisTx, Varian linear accelerator at doses from 18 to 24 Gy, the second was not exposed to radiation. During the study, we monitored cell viability and evaluated apoptotic activity, then each sample was amplified in two iterations. During the study, cell viability was monitored, apoptotic activity was assessed, and then each sample was amplified in two replicates. The relative copy number of genetic loci was determined by Real-Time qPCR (RT-qPCR).Results When comparing the relative copy number in the genetic loci of the H1299 non-small cell lung cancer cell culture after exposure to a high dose of ionizing radiation, a statistically significant decrease in the relative copy number of the CASP3 and RBBP8 genes was found, which may indicate a decrease in the potential of caspase-mediated tumor repopulation and an increase in the radiosensitivity of tumor cells.Conclusion Exposure to high doses of ionizing radiation leads to a detrimental effect on tumor cells and allows to overcome one of the mechanisms of radioresistance – tumor cell repopulation.

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Section: Introductionunclassified

Molecular alterations in the culture of lung cancer cells H1299 after exposure to high doses of ionizing radiation

Voshedskiy¹,

Sakun²,

Genkova³

et al. 2021

Innovacionnaâ medicina Kubani

Self Cite

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Specifics of Epidural Compression Syndrome Surgery in Patients with Spinal Malignancy

Закондырин

Rostorguev²,

Yundin

2022

Kreativnaâ hirurgiâ i onkologiâ

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Background. Epidural spinal cord compression (ESCC) is the most common neurological complication in metastatic spinal tumours.Materials and methods. The study included 87 spinal malignancy patients operated within 01.01.2014–30.09.2021. All patients had a type of palliative decompressive and stabilising surgery: standard posterior access (SPA, 55 patients), minimally invasive posterior access (MPA, 22 patients) or anterior access (AA, 10 patients).Results. The patient cohorts did not differ significantly by the duration of surgery, length of hospital stay, rates and types of postoperative complications. The AA cohort revealed a statistical difference by intraoperative blood loss. A Karnofsky performance status was statistically improved post- vs. pre-surgery (p < 0.05) at no significant change of Frankel neurological function status (p > 0.05). A Kaplan — Meier curve analysis showed no significant survival rate variation among the surgical techniques. Discussion. Our results suggest that posterior access interventions should be considered optimal. We report no statistical difference in the postoperative neurological and performance status dynamics between both cohorts, which encourages the MPA use in all patients with minimal epidural compression.Conclusion. Posterior access with cytoreductive tumour removal in anterior spinal cord compression is advantageous over anterior surgery. A posterior access surgery with minimal spinal canal decompression is recommended in all patients with grade 1 tumoural epidural compression.

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Metastatic Spinal Lesion with Minimal Epidural Compression: Surgical Treatment or Stereotactic Radiotherapy?

Kit,

Zakondyrin,

Grin

et al. 2024

Kreativnaâ hirurgiâ i onkologiâ

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Introduction. The choice of treatment between extracranial stereotactic radiotherapy and surgery for metastatic vertebral body tumors with minimum or no epidural compression of the dura mater is yet to be clearly defined. Materials and methods. The study enrolled 41 patients who received treatment at the National Medical Research Centre for Oncology (Rostov-on-Don, Russia) from January 1, 2014 to December 31, 2022. The inclusion criterion was the presence of a metastatic vertebral tumor, with minimal or no epidural compression of the dura mater and the radicular infundibulum (ESCC 0–1b). Patients were divided into two groups: 21 patients (SBRT group) received only extracranial stereotactic radiation therapy and 20 patients who underwent surgery followed by adjuvant extracranial stereotactic radiation therapy 1 month after surgery (Op.+Аd.SBRT). Results. The early postoperative period revealed no deterioration in the neurological status of patients in the SBRT group, no improvement in the Karnofsky performance status and no regression of pain syndrome, in contrast to patients in the Op+Аd.SBRT group. In a month after the surgery, tumors continued to grow in 3 patients (21%) of the SBRT group and only in 1 patient (6%) of the Oр.+Аd.SBRT group. Discussion. In the early postoperative period, the Op.+Аd.SBRT group showed an improvement in the functional status and a significantly more pronounced regression of the pain syndrome in the patients of the SBRT group, which can be explained by direct decompression of the compressed spinal root and elimination of increasing instability of the spinal column. Conclusion. Surgical treatment complemented by adjuvant extracranial stereotactic radiation therapy constitutes the preferred treatment for patients with metastatic spinal lesion with minimal epidural spread, without epidural compression of the spinal cord, with severe pain syndrome and signs of increasing instability of the spinal column.

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Novalis Tx radiosurgical platform experience in National Medical Research Centre for Oncology of the Ministry of Health of Russian

Cited by 3 publications

References 7 publications

Molecular alterations in the culture of lung cancer cells H1299 after exposure to high doses of ionizing radiation

Molecular alterations in the culture of lung cancer cells H1299 after exposure to high doses of ionizing radiation

Specifics of Epidural Compression Syndrome Surgery in Patients with Spinal Malignancy

Metastatic Spinal Lesion with Minimal Epidural Compression: Surgical Treatment or Stereotactic Radiotherapy?

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