Novel Adenosine Triphosphate-Based Nutraceutical Formulation to Prevent Non-Steroidal Anti-Inflammatory Drug Enteric Cell Toxicity: Preliminary <i>In Vitro</i> Evidence

Fratter, Andrea; Biagi, Damiano; Giacomini, Isabella; Montopoli, Monica; Cocetta, Veronica

doi:10.1089/jmf.2021.0019

Cited by 1 publication

(1 citation statement)

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“…Nonsteroidal anti-inflammatory drugs (NSAIDs) target the epithelium of the gastrointestinal system (Fletcher et al, 2021). If these medications are used to treat inflammation and pain, they have a detrimental effect on the digestive epithelia, which is their primary negative impact (Fratter et al, 2021). However, because NSAIDs decrease carcinogenesis in gastrointestinal tissues, they are considered an adjuvant to chemotherapy (Wang et al, 2021).…”

Section: Therapeutic Target and Treatment Strategy Of Autophagy Modulation In Gcmentioning

confidence: 99%

Potential Therapeutic Action of Autophagy in Gastric Cancer Managements: Novel Treatment Strategies and Pharmacological Interventions

et al. 2022

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Gastric cancer (GC), second most leading cause of cancer-associated mortality globally, is the cancer of gastrointestinal tract in which malignant cells form in lining of the stomach, resulting in indigestion, pain, and stomach discomfort. Autophagy is an intracellular system in which misfolded, aggregated, and damaged proteins, as well as organelles, are degraded by the lysosomal pathway, and avoiding abnormal accumulation of huge quantities of harmful cellular constituents. However, the exact molecular mechanism of autophagy-mediated GC management has not been clearly elucidated. Here, we emphasized the role of autophagy in the modulation and development of GC transformation in addition to underlying the molecular mechanisms of autophagy-mediated regulation of GC. Accumulating evidences have revealed that targeting autophagy by small molecule activators or inhibitors has become one of the greatest auspicious approaches for GC managements. Particularly, it has been verified that phytochemicals play an important role in treatment as well as prevention of GC. However, use of combination therapies of autophagy modulators in order to overcome the drug resistance through GC treatment will provide novel opportunities to develop promising GC therapeutic approaches. In addition, investigations of the pathophysiological mechanism of GC with potential challenges are urgently needed, as well as limitations of the modulation of autophagy-mediated therapeutic strategies. Therefore, in this review, we would like to deliver an existing standard molecular treatment strategy focusing on the relationship between chemotherapeutic drugs and autophagy, which will help to improve the current treatments of GC patients.

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Section: Therapeutic Target and Treatment Strategy Of Autophagy Modulation In Gcmentioning

confidence: 99%

Potential Therapeutic Action of Autophagy in Gastric Cancer Managements: Novel Treatment Strategies and Pharmacological Interventions

et al. 2022

View full text Add to dashboard Cite

show abstract

Novel Adenosine Triphosphate-Based Nutraceutical Formulation to Prevent Non-Steroidal Anti-Inflammatory Drug Enteric Cell Toxicity: Preliminary In Vitro Evidence

Cited by 1 publication

References 43 publications

Potential Therapeutic Action of Autophagy in Gastric Cancer Managements: Novel Treatment Strategies and Pharmacological Interventions

Potential Therapeutic Action of Autophagy in Gastric Cancer Managements: Novel Treatment Strategies and Pharmacological Interventions

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