Novel and efficient techniques in the discovery of antioxidant peptides

Zhang, Yuhao; Li, Yun; Ren, Tianyi; Xiao, Ping; Duan, Jin-ao

doi:10.1080/10408398.2023.2245052

Cited by 5 publications

(3 citation statements)

References 88 publications

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“…Some state-of-the-art technologies have shown efficient performance in screening MCPs. To this end, surface plasmon resonance (SPR) and SwitchSENSE ® technologies have been reviewed in our previous publication [10]. Both are characterized by high sensitivity and rapidity.…”

Section: Efficient Screening Based On Metal Ions Chelationmentioning

confidence: 99%

“…The laborious protocol has become a hindrance on the route to efficient screening. To this end, our previous publication introduced eight novel and efficient techniques for the discovery of antioxidant peptides [10]. Nevertheless, there are currently more cases of novel technologies in the efficient screening of antioxidant peptides that deserve to be reported.…”

Section: Introductionmentioning

confidence: 99%

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New Insights into Antioxidant Peptides: An Overview of Efficient Screening, Evaluation Models, Molecular Mechanisms, and Applications

Zhang,

Li,

Quan

et al. 2024

Antioxidants

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Antioxidant peptides are currently a hotspot in food science, pharmaceuticals, and cosmetics. In different fields, the screening, activity evaluation, mechanisms, and applications of antioxidant peptides are the pivotal areas of research. Among these topics, the efficient screening of antioxidant peptides stands at the forefront of cutting-edge research. To this end, efficient screening with novel technologies has significantly accelerated the research process, gradually replacing the traditional approach. After the novel antioxidant peptides are screened and identified, a time-consuming activity evaluation is another indispensable procedure, especially in in vivo models. Cellular and rodent models have been widely used for activity evaluation, whilst non-rodent models provide an efficient solution, even with the potential for high-throughput screening. Meanwhile, further research of molecular mechanisms can elucidate the essence underlying the activity, which is related to several signaling pathways, including Keap1-Nrf2/ARE, mitochondria-dependent apoptosis, TGF-β/SMAD, AMPK/SIRT1/PGC-1α, PI3K/Akt/mTOR, and NF-κB. Last but not least, antioxidant peptides have broad applications in food manufacture, therapy, and the cosmetics industry, which requires a systematic review. This review introduces novel technologies for the efficient screening of antioxidant peptides, categorized with a new vision. A wide range of activity evaluation assays, encompassing cellular models, as well as rodent and non-rodent models, are provided in a comprehensive manner. In addition, recent advances in molecular mechanisms are analyzed with specific cases. Finally, the applications of antioxidant peptides in food production, therapy, and cosmetics are systematically reviewed.

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Section: Efficient Screening Based On Metal Ions Chelationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

New Insights into Antioxidant Peptides: An Overview of Efficient Screening, Evaluation Models, Molecular Mechanisms, and Applications

Zhang,

Li,

Quan

et al. 2024

Antioxidants

Self Cite

View full text Add to dashboard Cite

show abstract

“…6 What makes bioactive peptides even more appealing is their ability to exhibit minimal side effects in the human body due to their natural origin. 1 Peptide segments with antioxidant properties can exert their antioxidant effects by scavenging free radicals, inhibiting peroxides, and chelating metal ions (Fe 2+ /Cu 2+ ), 7 which endows them with potential characteristics as food processing additives. Antioxidant peptides have been reported in various sources, such as pearl oyster meat, 8 oysters, 9 cottonseed, 2 and bitter buckwheat.…”

Section: Introductionmentioning

confidence: 99%