Novel Anti-Fatigue Compound: Imidazole Dipeptide

Nishitani, Masahito; Munekiyo, Yoshimi; Sugino, Tomohiro; Kajimoto, Osami

doi:10.1625/jcam.6.123

Cited by 6 publications

(3 citation statements)

References 33 publications

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“…Blood samples were collected 120 minutes after the glucose administration through puncturing heart. Blood glucose levels were measured by glucose oxidase method [18]. The percent lowering of blood glucose levels were calculated according to the formula described below.…”

Section: Methodsmentioning

confidence: 99%

A preliminary evaluation of antihyperglycemic and analgesic activity of Alternanthera sessilis aerial parts

Hossain

Faisal

Rahman

et al. 2014

BMC Complement Altern Med

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BackgroundAlternanthera sessilis is used by folk medicinal practitioners of Bangladesh for alleviation of severe pain. The objective of this study was to scientifically analyze the analgesic (non-narcotic) property of aerial parts of the plant along with antihyperglycemic activity.MethodsAntihyperglycemic activity was measured by oral glucose tolerance tests. Analgesic (non-narcotic) activity was determined by observed decreases in abdominal writhings in intraperitoneally administered acetic acid-induced pain model in mice.ResultsAdministration of methanol extract of aerial parts led to dose-dependent and significant reductions in blood glucose levels in glucose-loaded mice. At doses of 50, 100, 200 and 400 mg per kg body weight, the extract reduced blood sugar levels by 22.9, 30.7, 45.4 and 46.1%, respectively compared to control animals. By comparison, a standard antihyperglycemic drug, glibenclamide, when administered at a dose of 10 mg per kg body weight, reduced blood glucose level by 48.9%. In analgesic activity tests, the extract at the above four doses reduced the number of abdominal writhings by 27.6, 37.9, 41.4, and 44.8%, respectively. A standard analgesic drug, aspirin, reduced the number of writhings by 31.0 and 51.7%, respectively, when administered at doses of 200 and 400 mg per kg body weight.ConclusionThe results validate the folk medicinal use of the plant to alleviate pain. At the same time, the antihyperglycemic activity result suggests that the plant may be a potential source for blood sugar lowering drug(s).

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Section: Methodsmentioning

confidence: 99%

A preliminary evaluation of antihyperglycemic and analgesic activity of Alternanthera sessilis aerial parts

Hossain

Faisal

Rahman

et al. 2014

BMC Complement Altern Med

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show abstract

“…However, on the basis of their hydroxyproline content, approximately 25% of the peptides in the present fraction are derived from non-collagenous extracellular matrix proteins. To the best of our knowledge, there have been no reports about peptides with anti-hyperuricemic activity, except for imidazole dipeptides, which mildly moderate fatigue and consequently fatigue-induced hyperuricemia in humans (Nishitani, Munekiyo, Sugino, & Kajimoto, 2009;Quinlan, Lamb, Tilley, Evans, & Gutteridge, 1997). However, only negligible amounts of b-alanine, a constituent of imidazole dipeptides, were detected in the HCl hydrolysate of the present ethanol-soluble fraction.…”

Section: Discussionmentioning

confidence: 60%

Moderation of oxonate-induced hyperuricemia in rats via the ingestion of an ethanol-soluble fraction of a shark cartilage proteolytic digest

Murota¹,

Tamai²,

Baba³

et al. 2012

Journal of Functional Foods

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“…In amino acid analysis by UHPLC measurements, large amounts of L-Histidine were found in the mucus of farmed mackerel. Imidazole dipeptides consisting of L-Histidine are known as antioxidant peptides and have important bioregulatory functions such as antioxidant activity, anti-glycation effects, and anti-fatigue action 15,16 .…”

Section: Evaluation Of Antioxidant Activity By Orac Assay Andmentioning

confidence: 99%

Evaluation of Antioxidant Activity and Amino Acids in the Mucus of Mackerel for Cosmetic Applications

Tagami

Kuwahara

2020

J. Oleo Sci.

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IntroductionThe stratum corneum of the skin is located at the boundary between the inside of the skin and outside environment, functioning as a barrier against stimulation from the outside environment. When barrier function decreases, the water retained in the stratum corneum evaporates, leading to dry skin, which can cause inflammation and itching. This study is based on interview survey results that revealed improvement in symptoms such as atopic dermatitis and rough, itchy hands in people who had been handling mackerel for a long time. Previous studies of fish mucus reported the structure and functions of glycoprotein lectins, mucin, antioxidant, and antimicrobial peptides 1 4 . Glycoprotein, lectins, and mucin are high-molecular-weight materials, whereas antioxidants and antimicrobial peptides are low-molecular-weight materials. The mucus of fish is predominantly composed of the mucins of glycoprotein, whose amino acid compositions differ depending on the species 5 . Antioxidants and antimicrobial peptides are less susceptible to heat denaturation than proteins such as lectins and mucins.

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Novel Anti-Fatigue Compound: Imidazole Dipeptide

Cited by 6 publications

References 33 publications

A preliminary evaluation of antihyperglycemic and analgesic activity of Alternanthera sessilis aerial parts

A preliminary evaluation of antihyperglycemic and analgesic activity of Alternanthera sessilis aerial parts

Moderation of oxonate-induced hyperuricemia in rats via the ingestion of an ethanol-soluble fraction of a shark cartilage proteolytic digest

Evaluation of Antioxidant Activity and Amino Acids in the Mucus of Mackerel for Cosmetic Applications

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