Novel anticoagulant compound from fermented red alga Pachymeniopsis elliptica

Ekanayake, Prashani Mudika; Nikapitiya, Chamilani; Zoysa, Mahanama De; Whang, Ilson; Kim, Se Jae; Lee, Jehee

doi:10.1007/s00217-007-0802-x

Cited by 10 publications

(11 citation statements)

References 28 publications

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“…Ekanayake et al . () observed highest APTT value in fermented red seaweed Pachimeniopsis elliptica on 6th week of natural fermentation and reported lowest activity (43 s) in the fermented brown seaweed S. horneri .…”

Section: Discussionmentioning

confidence: 93%

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Potential of marine lactic acid bacteria to ferment Sargassum sp. for enhanced anticoagulant and antioxidant properties

2012

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Aim: To evaluate the suitability of marine lactic acid bacteria (LAB) as starter cultures for Sargassum sp. fermentation to enhance its antioxidant and anticoagulation activity. Methods and Results: LAB isolated from marine source were characterized for their ability to utilize seaweed as a sole carbon source and applied to Sargassum fermentation. Fermentation period was optimized by monitoring the fermented sample at regular interval for a period of 18 days. Results revealed that a fermentation period of 12 days was effective with maximum culture viability and other desirable characteristics such as pH, total titratable acidity, total and reducing sugars. Under optimum fermentation period, the sample fermented with P1-2CB-w1 (Enterococcus faecium) exhibited maximum anticoagulation activity and antioxidant activity. Conclusions: The study reveals a novel well-defined starter culture from marine origin intended for seaweed fermentation for recovery of bioactive molecules. Significance and Impact of the study: The study provides information for the enhancement of bioactive molecules in an eco-friendly manner and also paves a way towards the development of wide range of seaweed functional foods.

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Section: Discussionmentioning

confidence: 93%

“…; Ekanayake et al . ). Although these methods are found to be effective, there are several limitations such as toxicity, high cost and complex procedure.…”

Section: Introductionmentioning

confidence: 97%

Potential of marine lactic acid bacteria to ferment Sargassum sp. for enhanced anticoagulant and antioxidant properties

2012

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“…Algal anticoagulant polysaccharides also activate fibrinolysis system, modulate endothelial cell functions and possess anti-platelet activity [32]. Novel anticoagulant compounds have been recently isolated from fermented red alga Pachymeniopsis elliptica [33] and red seaweed Lomentaria catenata [34]. Marine organisms use chemical compounds to solve problems which also humans face.…”

Section: Macroalgaementioning

confidence: 99%

Exploring Marine Resources for Bioactive Compounds

et al. 2014

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Biodiversity in the seas is only partly explored, although marine organisms are excellent sources for many industrial products. Through close co-operation between industrial and academic partners, it is possible to successfully collect, isolate and classify marine organisms, such as bacteria, fungi, micro- and macroalgae, cyanobacteria, and marine invertebrates from the oceans and seas globally. Extracts and purified compounds of these organisms can be studied for several therapeutically and industrially significant biological activities, including anticancer, anti-inflammatory, antiviral, antibacterial, and anticoagulant activities by applying a wide variety of screening tools, as well as for ion channel/receptor modulation and plant growth regulation. Chromatographic isolation of bioactive compounds will be followed by structural determination. Sustainable cultivation methods for promising organisms and biotechnological processes for selected compounds can be developed, as well as biosensors for monitoring the target compounds. The (semi)synthetic modification of marine-based bioactive compounds produces their new derivatives, structural analogs and mimetics that could serve as hit or lead compounds and be used to expand compound libraries based on marine natural products. The research innovations can be targeted for industrial product development in order to improve the growth and productivity of marine biotechnology. Marine research aims at a better understanding of environmentally conscious sourcing of marine biotechnology products and increased public awareness of marine biodiversity. Marine research is expected to offer novel marine-based lead compounds for industries and strengthen their product portfolios related to pharmaceutical, nutraceutical, cosmetic, agrochemical, food processing, material and biosensor applications.

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“…and Fucus evanescens demonstrate powerful antitumorigenic potential (Vishchuk, Ermakova, & Zvyagintseva, 2013 ). To obtain the bioactives from the marine plants, researchers used acid− base hydrolysis, hot water or solvent extraction and enzymatic digestion (Ekanayake et al, 2008 ). Pachymeniopsis elliptica, Sargassum horneri and Ulva pertusa natural fermentation by adding sugar, water and keeping at room temperature (25 °C) for 3 months has been proposed as a method of active compounds release for potential anticoagulant activity.…”

Section: Marine Plant-based Fermented Productsmentioning

confidence: 99%

“…Pachymeniopsis elliptica, Sargassum horneri and Ulva pertusa natural fermentation by adding sugar, water and keeping at room temperature (25 °C) for 3 months has been proposed as a method of active compounds release for potential anticoagulant activity. It has been found that the fermentation process improving the anticoagulant properties of the polysaccharide compound (Ekanayake et al, 2008 ).…”

Section: Marine Plant-based Fermented Productsmentioning

confidence: 99%