Novel antigenic specificity involving the blood group antigen, Le a , in combination with onco-developmental antigen, SSEA-1, recognized by two monoclonal antibodies to human milk-fat globule membranes

Sequential alteration of peanut agglutinin binding-glycoprotein expression during progression of murine mammary neoplasia

“…Roles for both N-linked (Dennis & Laferte, 1989 and references therein) and 0-linked (Schirrmacher, 1982) oligosaccharides in invasion and metastasis have been postulated. Oncodevelopmental antigens have been detected in breast cancer specimens using monoclonal antibodies specific for blood group related carbohydrates (Feizi, 1985a;Feizi, 1985b;Gooi, 1985a;Gooi, 1985b) and PNA (Springer, 1984). Sialylation of various glycoconjugates correlates with metastatic phenotype in different systems (Benedetto et al, 1989;Bresalier et al, 1990;Corfield et al, 1990;Friedman et al, 1988;Passaniti & Hart, 1988;Dennis et al, 1989).…”

“…This seems to hold true for mammary neoplasia (Franklin, 1983;Gooi et al, 1985a;Gooi et al, 1985b;Howard et al, 1981;McKenzie & Xing, 1990;Muller-Holzner et al, 1985;Taylor-Papadimitriou et al, 1990). The role of transformation events, such as carcinogen treatment (Russo et al, 1988) or oncogene activation (Bolsher et al, 1988;Rak et al, 1991), in cell surface carbohydrate alterations have been proposed.…”

The Antitumor Monoclonal Antibody MOv2 Recognizes the Lewis A Hapten

“…Moreover, using these MAbs, the aberrant expression of the blood group antigens or their modified forms were described in human tumors of different origin (8). Particular attention was given to the expression of ABH, Lewis, sialylated-Le and sialylated-Le antigens in gastrointestinal (9-15), pancreatic (16), lung (17)(18), hepatocellular (19) and breast (20,21) carcinomas. Moreover, some authors reported the possibility of using blood group antigens or their precursors as tumor diagnostic (22,23) or prognostic (15,24) factors.…”