Novel Associations Between Major Histocompatibility Complex and Pediatric‐onset Inflammatory Bowel Disease

Abstract

One MHC haplotype is strongly linked with pediatric-onset IBD, whereas the need for immunomodulatory therapy and surgery outcome associates with other distinct MHC gene markers.

Genetic association and epistatic interaction of the interleukin-10 signaling pathway in pediatric inflammatory bowel disease

“…In addition, novel association of major histocompatibility complex haplotype with pediatric-onset IBD has been reported[5]. The multi-drug resistance gene MDR1 single nucleotide polymorphisms (SNPs) C1236T and G2577A/T have also been shown to be associated with CD in an Algerian pediatric CD population[6].…”

Human leucocyte antigens B*08, DRB1*03 and DRB1*13 are significantly associated with autoimmune liver and biliary diseases in Finnish children

“…In earlier studies, the onset of IBD in adults was also found to be associated with HLA‐DRB1*13 . However, a study on paediatric onset IBD carried out in Finland could not find this HLA association . In the literature, HLA‐DRB1*04 has been linked to AIH in older patients , whereas in many paediatric studies, this association has not been found and in some paediatric studies, DRB1*04 has even been suggested to have a protective role .…”

The complexity and diversity of major histocompatibility complex challenge disease association studies

“…In other studies, however, these same alleles/combinations thereof have been established in neurological disorders such as Alzheimer's disease and multiple sclerosis, Parkinson's disease, narcolepsy, and autism (Table ) . In addition, an increased risk of several inflammatory diseases such as sarcoidosis, especially nonresolving, pediatric‐onset inflammatory bowel diseases (both Crohn's disease and ulcerative colitis), adult ulcerative colitis, and systemic lupus erythematosus in European descent, African‐American, and Hispanic populations have been associated with DRB1*15:01/15:03 ‐related haplotypes …”

“…C4A deficiency is especially found in association with HLA‐DRB1*03:01 and HLA‐DRB1*13:02 and C4B deficiency with HLA‐DRB1*01:01, *04:01, *08:01 , and *13:01 in the Finnish population. Because class III clusters are involved with the activation of immune and inflammatory processes, grouping these functional clusters with HLA‐DRB1 alleles offers wider perspective for disease association studies and reveals predisposing or protective associations between markers and disease loci not detectable with a single MHC allele …”

“…Because class III clusters are involved with the activation of immune and inflammatory processes, grouping these functional clusters with HLA-DRB1 alleles offers wider perspective for disease association studies and reveals predisposing or protective associations between markers and disease loci not detectable with a single MHC allele. 35…”