Novel associations between specific sperm morphological defects and leukocytospermia

Aziz, Nabil; Agarwal, Ashok; Lewis-Jones, Iwan; Sharma, Rakesh K.; Thomas, Anthony J.

doi:10.1016/j.fertnstert.2004.02.112

Cited by 110 publications

(87 citation statements)

References 35 publications

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“…In our study, leukocytospermic infertile men showed decreased in sperm characteristics compared with non-leukocytospermic, similar results found by studies of [30,31,32,33].…”

Section: B-a Comparison Between Semen Parameters and Mda Among Leuko supporting

confidence: 92%

The Seminal Plasma MDA Level as Bio-Marker for Oxidative Stress and Their Impact on Seminogram in Primary Infertile Males, Erbil-Kurdistan Region, Iraq

AL-Naqshbandi¹,

AL-Barzinji²

2017

Cihan Univ.-Erbil Sci. J.

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Male infertility is an important medical and psychosocial problem worldwide. Therefore, it is important to identify new and non-conventional factors that may play significant role in male infertility. Current study focused on detecting more risk factors and markers for primary infertility in order to develop interventions for investigation and prevent their progressions. Oxidative stress has recently been identified as an underlying mechanism of numerous sources. The aim of the present study was therefore to evaluate whether there is an association between oxidative stress and male infertility in Erbil city subjects. The present prospective case control study was carried out between March to May 2013, in Maternity Teaching Hospital/in-vitro fertilization center and private clinical laboratory. 75 infertile males represent patients group were enrolled in this study. Apparently 40 healthy individuals who have no history of clinical evidence of any disease were also joined to this study as control group. Malondialdehyde (MDA), the marker of lipid peroxidation was measured in the seminal fluid of fertile and infertile male subjects. The sperm count, sperm morphology and motility, as well as semen volume were all found significantly lower in infertile subjects compared with fertile subjects (p<0.01). In seminal plasma, the MDA level was found significantly higher in infertile group (p<0.05). Lifestyle behaviours such as varicocele repair, cigarette smoking and alcohol consumption, all enhance the generation of ROS level in the seminal plasma, such elevation associated with decreased sperm quality particularly in term of sperm count and sperm motility that leading to increase male infertility.

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“…In our study, leukocytospermic infertile men showed decreased in sperm characteristics compared with non-leukocytospermic, similar results found by studies of [30,31,32,33].…”

Section: B-a Comparison Between Semen Parameters and Mda Among Leuko supporting

confidence: 92%

The Seminal Plasma MDA Level as Bio-Marker for Oxidative Stress and Their Impact on Seminogram in Primary Infertile Males, Erbil-Kurdistan Region, Iraq

AL-Naqshbandi¹,

AL-Barzinji²

2017

Cihan Univ.-Erbil Sci. J.

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“…16 It also has been reported that a significant positive correlation exists between pyospermia and compromised sperm morphology, including tail defects, acrosomal damage, and high SDI scores. 17 In another study, the findings suggest that leukocytes had a positive association with normal morphology and progressive motility. 18 The same finding was also observed in our study.…”

Section: Discussionmentioning

confidence: 91%

An Association between Pus Cells and Semen Parameters in Infertile Pakistani Males = العلاقة بين الخلايا القيحية و معالم السائل المنوي عند الذكور الباكستانيين المصابين بالعقم

Khan¹,

Mohammad²,

Deepa

et al. 2012

SQUMJ

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abstract:Objectives: This study evaluated the association between pus cells and semen parameters in infertile Pakistani males. Methods: A cross-sectional descriptive study was carried out in the Department of Reproductive Physiology/Health, National Institute of Health, Islamabad, Pakistan, from 2004 to 2009. A total of 1,521 subjects were analysed, along with 97 proven fathers as controls. Results: The mean of pus cells was 7.43 ± 0.43, 4.35 ± 0.34, and 4.26 ± 0.17 per high field in teratozoospermic, oligoasthenozoospermic, and asthenozoospermic groups, respectively, while it was 3.25 ± 0.26, 3.10 ± 0.19, and 2.98 ± 0.04 per high field in azoospermic, oligozoospermic and the proven father groups, respectively. The fewest pus cells were observed among proven fathers, which varied nonsignificantly (P >0.05) with all cases, except with teratozoospermic, oligozoospermic, and oligoasthenozoospermic cases. Pus cells showed an inverse relationship to sperm motility and count, except in azoospemia cases. Similarly, the fewest pus cells were observed among groups where normal forms where significantly more frequent (P <0.05). More pus cells were observed in cases where motility, and concentration or morphology was compromised. Similarly, low pus cell counts were seen in cases where sperm had the fewest head and neck defects. All kinds of sperm defects varied non-significantly (P >0.05) between proven fathers and normal concentration cases. Conclusion: High pus cell counts were observed in various subclasses of infertile patients. Ignorance of this pyospermic factor will make pyospermic patients to be misdiagnosed as normozoospermic. Therefore, the presence of pyospermia must be considered by physicians as a male infertility factor. Keywords: Pyospermia; Male infertility; Pakistan. Association between Pus Cells and SemenParameters in Infertile Pakistani Males

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“…16,17 Several previous studies have shown that leukocytes play a physiological role in the immune surveillance and the removal of abnormal spermatozoa. [18][19][20] Although the mechanisms have not been clarified, some authors have shown a close relationship between leukocytospermia and morphological and functional sperm alterations, including teratozoospermia and sperm necrosis. [18][19][20] According to these studies, high leukocyte concentrations in the ejaculate compromise spermatozoa structural integrity, resulting in alterations of the acrosome, nucleus and tail.…”

Section: Discussionmentioning

confidence: 99%

Different levels of Cd45pos leukocytes in the semen of patients with low testicular volume

Vignera

Condorelli

Morgia

et al. 2015

Int J Immunopathol Pharmacol

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The testis consists of two structurally distinct compartments: the interstitial cell or Leydig cell compartment and the seminiferous tubules compartment, which contains germ cells and Sertoli cells. These two compartments are responsible for the two main testicular actions: the endocrine and the exocrine functions (production of androgens and spermatozoa). In clinical practice, testicular volume (TV) can be estimated by a physical examination using an orchidometer, but it can be more objectively assessed by an ultrasound examination, which is less affected by factors such as scrotal effusions, varicose veins, intra-scrotal masses, testicular pain, and distinction with the adjacent anatomical structures. It has been widely shown that TV reflects its function including both endocrine (androgen decline) and reproductive activity (abnormal sperm parameters). The testicular functional characterisation in relation to different TV is traditionally correlated to parameters such as sperm concentration, motility, morphology, gonadotropins and total testosterone serum concentrations. 1,2 Different levels of Cd45pos leukocytes in the semen of patients with low testicular volume S La Vignera, 1 RA Condorelli, 1 G Morgia, 2 V Favilla, 2 GI Russo, 2 S Cimino, 2 E Vicari 1 and AE Calogero 1 AbstractThe aim of this study was to evaluate the concentrations of CD45pos leukocytes in the semen samples of infertile patients with low testicular volume (TV) compared to subjects with normal TV. The testis was considered normal in size when it had a volume between 15 and 25 cm 3 , low-normal with a volume between 10 and 12 cm 3 and hypotrophic when the volume was <10 cm 3 . The patients with low testicular volume (<10 cm 3 ) showed significantly higher concentrations of CD45pos leukocytes compared to other groups (P <0.05). The correlation analysis showed the presence of a positive linear relationship between CD45pos leukocytes and the percentage of immature germ elements (r = 0.88; P <0.05) and between CD45pos leukocytes and the percentage of spermatozoa with phosphatidylserine externalisation (r = 0.90; P <0.05) as well as a negative linear relationship between the percentage of spermatozoa with normal morphology and the seminal CD45pos leukocyte concentrations ( r = -0.75; P <0.05). The results of this study showed that patients with low testicular volume (<10 cm 3 ) have significantly increased CD45pos leukocyte concentrations associated with increased percentages of immature germ elements, spermatozoa with signs of early apoptosis and spermatozoa with abnormal morphology.

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Novel associations between specific sperm morphological defects and leukocytospermia

Cited by 110 publications

References 35 publications

The Seminal Plasma MDA Level as Bio-Marker for Oxidative Stress and Their Impact on Seminogram in Primary Infertile Males, Erbil-Kurdistan Region, Iraq

The Seminal Plasma MDA Level as Bio-Marker for Oxidative Stress and Their Impact on Seminogram in Primary Infertile Males, Erbil-Kurdistan Region, Iraq

An Association between Pus Cells and Semen Parameters in Infertile Pakistani Males = العلاقة بين الخلايا القيحية و معالم السائل المنوي عند الذكور الباكستانيين المصابين بالعقم

Different levels of Cd45pos leukocytes in the semen of patients with low testicular volume

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