Novel B melatonin-loaded chitosan microcapsules: in vitro characterization and antiapoptosis efficacy for aflatoxin B1-induced apoptosis in rat liver

Alleviation of aflatoxin B1-induced oxidative stress in HepG2 cells by volatile extract from Allii Fistulosi Bulbus

“…Similarly, Chan et al (2003) reported that glycyrrhizic acid, a major component of licorice, displayed protective effects against AFB 1 -induced oxidative stress. It was also observed in the current study that AFB 1 exposure caused increase in the levels of TBARS as an index of cellular lipid peroxidation and decrease of GSH content in HepG2 cells, which is in agreement with findings reported previously (Abdel-Wahhab and Aly, 2003;El-Gibaly et al, 2003). VEAF pretreatment significantly reduced the levels of TBARS, while increasing the level of GSH in AFB1-treated HepG2 cells (Fig.…”

Hepatoprotective effect of ethanolic extract of Phyllanthus amarus Schum. et Thonn. on aflatoxin B1-induced liver damage in mice

“…In our study, the increase in TBARS levels in the liver of aflatoxin treated mice could be due to this toxic property of aflatoxin B 1 . The increase in TBARS levels in aflatoxin treated animals is in agreement with findings reported previously for rat liver (Abdel-Wahab and Aly, 2003;El-Gibaly et al, 2003) as well as liver and kidney of mice (Verma and Nair, 1999).…”

Does Bougainvillea spectabilis protect Swiss Albino Mice from Aflatoxin-induced Hepatotoxicity?

“…It is an autocatalytic free radical process and could be responsible for DNA damage (Shirali et al, 1994;Mustafa et al, 2015) which results in impaired membrane function, structural integrity (Gutteridge and Halliwell, 1988) and inactivation of number of membrane bound enzymes and protein receptor. Inclined level of TBARS content in AFB 1 treated rat and mice liver tissue has also been previously reported (Verma and Nair, 2002;El-Gibaly et al, 2003).…”