Novel bilayer coating on gentamicin-loaded titanium nanotube for orthopedic implants applications

Shaygani, Hossein; Seifi, Saeed; Shamloo, Amir; Golizadeh, Mortaza; Rahnamaee, Seyed Yahya; Alishiri, Mojgan; Ebrahimi, Sina

doi:10.1016/j.ijpharm.2023.122764

Cited by 20 publications

(1 citation statement)

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“…Composite coating formed by alginate crosslinking with collagen enhances the cell adhesion of titanium implants [80,81]. Alginate and chitosan coating improves the biomineralization, the antibacterial activity, and corrosion resistance [75,82]. The addition of Ag further promotes the antibacterial ability and reduces the bacterial adhesion [83,84].…”

Section: Alginate-based Hydrogel Coatingmentioning

confidence: 99%

Progress in Surface Modification of Titanium Implants by Hydrogel Coatings

Chen

Feng

Xia

et al. 2023

Gels

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Although titanium and titanium alloys have become the preferred materials for various medical implants, surface modification technology still needs to be strengthened in order to adapt to the complex physiological environment of the human body. Compared with physical or chemical modification methods, biochemical modification, such as the introduction of functional hydrogel coating on implants, can fix biomolecules such as proteins, peptides, growth factors, polysaccharides, or nucleotides on the surface of the implants, so that they can directly participate in biological processes; regulate cell adhesion, proliferation, migration, and differentiation; and improve the biological activity on the surface of the implants. This review begins with a look at common substrate materials for hydrogel coatings on implant surfaces, including natural polymers such as collagen, gelatin, chitosan, and alginate, and synthetic materials such as polyvinyl alcohol, polyacrylamide, polyethylene glycol, and polyacrylic acid. Then, the common construction methods of hydrogel coating (electrochemical method, sol–gel method and layer-by-layer self-assembly method) are introduced. Finally, five aspects of the enhancement effect of hydrogel coating on the surface bioactivity of titanium and titanium alloy implants are described: osseointegration, angiogenesis, macrophage polarization, antibacterial effects, and drug delivery. In this paper, we also summarize the latest research progress and point out the future research direction. After searching, no previous relevant literature reporting this information was found.

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