Novel bile acid derivatives induce apoptosis via a p53-independent pathway in human breast carcinoma cells

Im, Eun‐Ok; Choi, Yung Hyun; Paik, Kee-Joo; Suh, Hongsuk; Jin, Youngeup; Kim, Kyu‐Won; Yoo, Young Hyun; Kim, Nam Deuk

doi:10.1016/s0304-3835(00)00671-6

Cited by 78 publications

(77 citation statements)

References 37 publications

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“…Recently, it was reported that several synthetic bile acids induced apoptosis in human hepatocellular carcinoma cells, human breast carcinoma cells, and human leukemic T cells Park et al, 1997;Im et al, 1999;Im et al, 2001), and inhibited angiogenesis in human hepatocellular carcinoma cells . Moreover, UDCA and its synthetic derivatives, HS-1030 and HS-1183, inhibited SV40 DNA replication, and predominantly inhibited the initiation stage of DNA replication .…”

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confidence: 99%

Synthetic Bile Acids: Novel Mediators of Apoptosis

Kim¹,

Im²,

Choi³

et al. 2002

BMB Reports

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confidence: 99%

Synthetic Bile Acids: Novel Mediators of Apoptosis

Kim¹,

Im²,

Choi³

et al. 2002

BMB Reports

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“…They have apoptosis-inducing effects in various cancer cells, such as leukemia and breast cancer cells (6)(7)(8)(9). We have demonstrated that the synthetic CDCA derivative, HS-1200, has an apoptotic effect on p815 mastocystoma cells when used in combination therapy with lactacystin (10).…”

Section: Discussionmentioning

confidence: 96%

“…HS-1200 was synthesized as described previously (8). Bile acids were dissolved in 100% ethanol and stored at -20˚C before the experiments and dilutions were made in a culture medium.…”

Section: Methodsmentioning

confidence: 99%

A novel chenodeoxycholic derivative HS-1200 enhances radiation-induced apoptosis in MCF-7 cells

Yee

Song²,

Jeong³

et al. 2007

Oncol Rep

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“…Apoptotic cell death due to the synthetic bile acid derivatives was also confirmed by DNA fragmentation (13). It has been proposed that the DNA fragmentation resulted from the loss of compartmentalization of DNase I, which would reach the nucleus due to the breakdown of the endoplasmic reticulum and nuclear membrane.…”

Section: Discussionmentioning

confidence: 97%

“…The L-phenyl alanine benzyl ester (HS-1199) and L-alanine benzyl ester (HS-1200) conjugates of CDCA induced apoptosis via a p53-independent pathway in human breast carcinoma cells (13), and also showed apoptotic activity in human leukemic T cells through the activation of caspases (12). This study was conducted to explore the fundamental mechanism via which synthetic CDCA derivatives regulate apoptosis and their potential therapeutic use in stomach cancer cells.…”

Section: Introductionmentioning

confidence: 99%