Novel bio-inspired three-dimensional nanocomposites based on montmorillonite and chitosan

Zheng, Xiu Cheng; Xu, Minghan; Yang, Shuai; Omonov, Shakhzodjon; Huang, Shuaijian; Zhao, Jing; Ruan, Huajun; Zeng, Minfeng

doi:10.1016/j.ijbiomac.2020.10.070

Cited by 11 publications

(8 citation statements)

References 57 publications

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“…Why this is so important for COVID-19 therapy is the key question we focused on throughout our experimental studies. In fact, NIC has been well known for its anti-viral efficacy on a wide variety of viral infections, as was reviewed by Xu et al (2020) [64]. Nevertheless, the major limitation associated with its poor water solubility has been an ongoing challenging issue for pharmacologists.…”

Section: Clinical Perspectivesmentioning

confidence: 99%

“…Therefore, inorganic-based nano-structures could be an alternative to enhance the overall action of the poorly soluble NIC drug. Among the inorganic nanomaterials, clay-based nanoparticles (NPs), in particular layered double hydroxide (LDH) [24] and montmorillonite (MMT) [25][26][27][28][29][30][31][32][33][34], have been widely explored for nanomedical applications owing to their excellent biocompatibility, biodegradability, and stimuli-responsive characteristics [35,36].…”

Section: Introductionmentioning

confidence: 99%

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Hydrotalcite–Niclosamide Nanohybrid as Oral Formulation towards SARS-CoV-2 Viral Infections

et al. 2021

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COVID-19 has been affecting millions of individuals worldwide and, thus far, there is no accurate therapeutic strategy. This critical situation necessitates novel formulations for already existing, FDA approved, but poorly absorbable drug candidates, such as niclosamide (NIC), which is of great relevance. In this context, we have rationally designed NIC-loaded hydrotalcite composite nanohybrids, which were further coated with Tween 60 or hydroxypropyl methyl cellulose (HPMC), and characterized them in vitro. The optimized nanohybrids showed particle sizes <300 nm and were orally administrated to rats to determine whether they could retain an optimum plasma therapeutic concentration of NIC that would be effective for treating COVID-19. The pharmacokinetic (PK) results clearly indicated that hydrotalcite-based NIC formulations could be highly potential options for treating the ongoing pandemic and we are on our way to understanding the in vivo anti-viral efficacy sooner. It is worth mentioning that hydrotalcite–NIC nanohybrids maintained a therapeutic NIC level, even above the required IC50 value, after just a single administration in 8–12 h. In conclusion, we were very successfully able to develop a NIC oral formulation by immobilizing with hydrotalcite nanoparticles, which were further coated with Tween 60 or HPMC, in order to enhance their emulsification in the gastrointestinal tract.

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Section: Clinical Perspectivesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hydrotalcite–Niclosamide Nanohybrid as Oral Formulation towards SARS-CoV-2 Viral Infections

et al. 2021

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“…Processing conditions can dramatically influence the obtained hierarchical structure. Several processes have been reported, such as suspension casting, doctor blading, vacuum-assisted self-assembly, melt compounding, in situ polymerization, etc. , About a decade ago, bioinspired polymer nanocomposites saw much advance with water-based and large-scale methodologies, akin to paper-making. ,,, Since then, the focus has shifted to the optimization of polymeric core–shell particles, followed by solvent removal. ,, The ideal conditions to realize aligned assemblies have been extensively adjusted. Nevertheless, these often are formed by intercalated structures, with restacking still observed at higher filler concentrations. ,− Above all, these efforts have led to a great number of mechanisms being proposed for polymer-particle association and (re)organization.…”

Section: Introductionmentioning

confidence: 99%

Systematic Study of the Nanostructures of Exfoliated Polymer Nanocomposites

Espíndola,

Zlopasa,

Picken

2023

Macromolecules

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High-performance bioinspired materials have shown rapid development over the last decade. Examples are brick-and-mortar hierarchical structures, which are often achieved via solvent evaporation. Although good properties are claimed, most systems are composed of stacked or intercalated platelets. Exfoliation is a crucial step to give ultimate anisotropic properties, e.g., thermal, mechanical, and barrier properties. We propose a general framework for all the various types of micro-scale structures that should be distinguished for 2D filler nanocomposites. In particular, the exfoliated state is systematically explored by the immobilization of montmorillonite platelets via (gelatin) hydrogelation. Scattering techniques were used to evaluate this strategy at the level of the particle dispersion and the regularity of spatial arrangement. The gelatin/montmorillonite exfoliated nanostructures are fully controlled by the filler volume fraction since the observed gallery d-spacings perfectly fall onto the predicted values. Surprisingly, X-ray analysis also revealed short-and quasi long-range arrangement of the montmorillonite clay at high loading.

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“…[2][3][4] The design of hierarchically structured composites from 2D nanoparticles has already been extended to clay silicates, (reduced) graphene oxide, boron nitride, MXenes, dichalcogenides, among others. [5][6][7][8] In general, the anisotropic materials show desired thermal, mechanical, conductive, and barrier properties. For instance, they combine excellent stiffness and toughness.…”

mentioning

confidence: 99%

“…9,10,12,13 Since then, the focus has shifted to the optimization of polymeric core-shell particles, followed by solvent removal. 5,6,14 The ideal conditions to realize aligned assemblies have been extensively adjusted. Nevertheless, these often are formed by intercalated structures, with restacking still observed at higher filler concentrations.…”

mentioning

confidence: 99%

Systematic study of the nanostructures of exfoliated polymer nanocomposites

Espíndola

Zlopaša

Picken

2023

Preprint

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High-performance bioinspired materials have shown rapid development over the last decade. Examples are brick-and-mortar hierarchical structures, which are often achieved via solvent evaporation. Although good properties are claimed, most systems are composed of stacked or intercalated platelets. Exfoliation is a crucial step to give ultimate anisotropic properties, e.g. thermal, mechanical and barrier properties. We propose a general framework for all the various types of micro-scale structures that should be distinguished for 2D-filler nanocomposites. In particular, the exfoliated state is systematically explored by the immobilization of montmorillonite platelets via (gelatin) hydrogelation. Scattering techniques were used to evaluate this strategy at the level of the particle dispersion and the regularity of spatial arrangement. The gelatin/montmorillonite exfoliated nanostructures are fully controlled by the filler volume fraction since the observed gallery d-spacings perfectly fall onto the predicted values. Surprisingly, X-ray analysis also revealed short- and quasi long-range arrangement of the MMT at high loading.

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Novel bio-inspired three-dimensional nanocomposites based on montmorillonite and chitosan

Cited by 11 publications

References 57 publications

Hydrotalcite–Niclosamide Nanohybrid as Oral Formulation towards SARS-CoV-2 Viral Infections

Hydrotalcite–Niclosamide Nanohybrid as Oral Formulation towards SARS-CoV-2 Viral Infections

Systematic Study of the Nanostructures of Exfoliated Polymer Nanocomposites

Systematic study of the nanostructures of exfoliated polymer nanocomposites

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