Novel Bioactive and Therapeutic Dental Polymeric Materials to Inhibit Periodontal Pathogens and Biofilms

Chi, Minghan; Qi, Manlin; A, Lan; Wang, Ping; Weir, Michael D.; Melo, Mary Anne S.; Sun, Xin; Dong, Biao; Li, Chunyan; Wu, Jianhua; Wang, Lin; Xu, Hockin H.K.

doi:10.3390/ijms20020278

Cited by 66 publications

(63 citation statements)

References 178 publications

(214 reference statements)

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“…Because guided tissue regeneration membrane with silver nanoparticles reduced adherence and penetration of bacteria, treatment of intrabony defects using guided tissue regeneration membrane with silver nanoparticles can improve clinical success. 44 Silver nanoparticles were reported to possess an antiinflammatory effect, through modulation of the level of inflammatory cytokines and growth factors. 45 Periodontal dressing coated with silver nanoparticles can be used to treat gingival wounds.…”

Section: Periodontal Treatmentmentioning

confidence: 99%

<p>The Antibacterial Mechanism of Silver Nanoparticles and Its Application in Dentistry</p>

Yin¹,

Zhang²,

Zhao³

et al. 2020

IJN

1,208

681

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Nanotechnology has recently emerged as a rapidly growing field with numerous biomedical science applications. At the same time, silver has been adopted as an antimicrobial material and disinfectant that is relatively free of adverse effects. Silver nanoparticles possess a broad spectrum of antibacterial, antifungal and antiviral properties. Silver nanoparticles have the ability to penetrate bacterial cell walls, changing the structure of cell membranes and even resulting in cell death. Their efficacy is due not only to their nanoscale size but also to their large ratio of surface area to volume. They can increase the permeability of cell membranes, produce reactive oxygen species, and interrupt replication of deoxyribonucleic acid by releasing silver ions. Researchers have studied silver nanoparticles as antimicrobial agents in dentistry. For instance, silver nanoparticles can be incorporated into acrylic resins for fabrication of removable dentures in prosthetic treatment, composite resin in restorative treatment, irrigating solution and obturation material in endodontic treatment, adhesive materials in orthodontic treatment, membrane for guided tissue regeneration in periodontal treatment, and titanium coating in dental implant treatment. Although not all authorities have acknowledged the safety of silver nanoparticles, no systemic toxicity of ingested silver nanoparticles has been reported. A broad concern is their potential hazard if they are released into the environment. However, the interaction of nanoparticles with toxic materials and organic compounds can either increase or reduce their toxicity. This paper provides an overview of the antibacterial use of silver nanoparticles in dentistry, highlighting their antibacterial mechanism, potential applications and safety in clinical treatment.

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Section: Periodontal Treatmentmentioning

confidence: 99%

<p>The Antibacterial Mechanism of Silver Nanoparticles and Its Application in Dentistry</p>

Yin¹,

Zhang²,

Zhao³

et al. 2020

IJN

1,208

681

View full text Add to dashboard Cite

show abstract

“…Beg et al have described the methodical development of a new in situ gel formulation containing poly(lactide-co-glycolide) PLGA nanoparticles for targeted delivery of moxifloxacin (MOX) against bacterial periodontitis [ 71 , 119 , 120 ]. MOX-PLGA nanoparticle-loaded in situ gel formulation was prepared by the cold mixing method.…”

Section: Micro- and Nanoparticlesmentioning

confidence: 99%

Polymeric Carriers for Delivery Systems in the Treatment of Chronic Periodontal Disease

et al. 2020

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Periodontitis (PD) is a chronic inflammatory disease of periodontal tissues caused by pathogenic microorganisms and characterized by disruption of the tooth-supporting structures. Conventional drug administration pathways in periodontal disease treatment have many drawbacks such as poor biodistribution, low selectivity of the therapeutic effect, burst release of the drug, and damage to healthy cells. To overcome this limitation, controlled drug delivery systems have been developed as a potential method to address oral infectious disease ailments. The use of drug delivery devices proves to be an excellent auxiliary method in improving the quality and effectiveness in periodontitis treatment, which includes inaccessible periodontal pockets. This review explores the current state of knowledge regarding the applications of various polymer-based delivery systems such as hydrogels, liposomes, micro-, and nanoparticles in the treatment of chronic periodontal disease. Furthermore, to present a more comprehensive understanding of the difficulties concerning the treatment of PD, a brief description of the mechanism and development of the disease is outlined.

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“…Progress in understanding the etiology, epidemiology, and microbiology of periodontal pocket flora has called for new antimicrobial therapeutic schemes for oral diseases [42]. Distinctive means and compounds may be used to prevent oral infections.…”

Section: Compounds With Activity Against Oral Infectionsmentioning

confidence: 99%

Management of Streptococcus mutans-Candida spp. Oral Biofilms’ Infections: Paving the Way for Effective Clinical Interventions

Salehi

Kręgiel

Mahady

et al. 2020

JCM

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Oral diseases are considered the most common noncommunicable diseases and are related to serious local and systemic disorders. Oral pathogens can grow and spread in the oral mucosae and frequently in biomaterials (e.g., dentures or prostheses) under polymicrobial biofilms, leading to several disorders such as dental caries and periodontal disease. Biofilms harbor a complex array of interacting microbes, increasingly unapproachable to antimicrobials and with dynamic processes key to disease pathogenicity, which partially explain the gradual loss of response towards conventional therapeutic regimens. New drugs (synthesized and natural) and other therapies that have revealed promising results for the treatment or control of these mixed biofilms are presented and discussed here. A structured search of bibliographic databases was applied to include recent research. There are several promising new approaches in the treatment of Candida spp.–Streptococcus mutans oral mixed biofilms that could be clinically applied in the near future. These findings confirm the importance of developing effective therapies for oral Candida–bacterial infections.

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Novel Bioactive and Therapeutic Dental Polymeric Materials to Inhibit Periodontal Pathogens and Biofilms

Cited by 66 publications

References 178 publications

<p>The Antibacterial Mechanism of Silver Nanoparticles and Its Application in Dentistry</p>

<p>The Antibacterial Mechanism of Silver Nanoparticles and Its Application in Dentistry</p>

Polymeric Carriers for Delivery Systems in the Treatment of Chronic Periodontal Disease

Management of Streptococcus mutans-Candida spp. Oral Biofilms’ Infections: Paving the Way for Effective Clinical Interventions

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