2020
DOI: 10.3390/ma13051096
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Novel Bioactive and Therapeutic Root Canal Sealers with Antibacterial and Remineralization Properties

Abstract: According to the American Dental Association Survey of Dental Services Rendered (published in 2007), 15 million root canal treatment procedures are performed annually. Endodontic therapy relies mainly on biomechanical preparation, chemical irrigation and intracanal medicaments which play an important role in eliminating bacteria in the root canal. Furthermore, adequate obturation is essential to confine any residual bacteria within the root canal and deprive them of nutrients. However, numerous studies have sh… Show more

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Cited by 37 publications
(29 citation statements)
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References 94 publications
(227 reference statements)
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“…QAMs are promising for incorporation into composites, primers and adhesives due to their antimicrobial activity and low toxicity [ 32 , 47 , 48 ]. DMAHDM has a positively-charged quaternary amine N + and a long alkyl chain with a chain length of 16 [ 49 , 50 ].…”
Section: Discussionmentioning
confidence: 99%
See 2 more Smart Citations
“…QAMs are promising for incorporation into composites, primers and adhesives due to their antimicrobial activity and low toxicity [ 32 , 47 , 48 ]. DMAHDM has a positively-charged quaternary amine N + and a long alkyl chain with a chain length of 16 [ 49 , 50 ].…”
Section: Discussionmentioning
confidence: 99%
“…In previous studies, several novel QAMs were used in a dental product, including 12-methacryloyloxydodecyl-pyridinium bromide (MDPB) [ 24 ], quaternary ammonium dimethacrylate (QADM) [ 25 ], quaternary ammonium-polyethylenimine (QPEI) [ 26 , 27 ], methacryloxylethyl cetyl dimethyl ammonium chloride (DMAE-CB) [ 28 ], dimethylaminododecyl methacrylate (DMADDM) [ 29 ] and dimethylaminohexadecyl methacrylate (DMAHDM) [ 30 ]. In addition, these QAMs with varying alkyl chain lengths had acceptable low cytotoxicity against human gingival fibroblasts and odontoblast-like cells, matching the low cytotoxicity of commercial dental monomers in clinical use [ 31 , 32 ]. DMAHDM with an alkyl chain length of 16 was incorporated into resins and presented a strong antimicrobial ability with a low level of cytotoxicity [ 30 , 32 ].…”
Section: Introductionmentioning
confidence: 99%
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“…While root canal fillings are supposed to achieve an optimum seal to prevent the growth of the residual bacteria, the complete removal of biofilms is not always possible. Chemomechanical decontamination may not reach areas with limited accessibility, such as isthmus, lateral canals, and apical ramifications, keeping the tooth at a higher risk of re-infection [ 107 ]. Therefore, developing new adjunctive strategies to reduce the bacterial load in the root canal system is crucial to enhance the longevity of root canal treatment and minimize the risk of re-infection.…”
Section: Contact-killing Materials As a Strategy In Resin-based Rementioning
confidence: 99%
“…Metallic nanoparticles have been incorporated into root canal sealers to impart antibacterial properties in root canal sealers [ 107 ]. The ion release behavior of these materials may not provide a long-lasting effect.…”
Section: Contact-killing Materials As a Strategy In Resin-based Rementioning
confidence: 99%