Novel Bioactive Glass as a Potential Clinical Appliance

Abstract

This paper examined the biocompatibility with the bone of novel types of bioactive glass (AP40, RKKP) in vivo. And we investigated the possibility to clinical applications. For the experimental studies, mirror polished titanium, bioactive glasses (RRKP and AP40) and coated HA (hydroxyapatite) were prepared. The investigation period was 72 weeks and observations were conducted at the interface by toluidine staining (undecalcified section) and by TEM (transmission electron microscopy). As a result, novel bioactive glasses are considered as biomaterials that can be fully applied in clinical practice as bone filling materials, scaffolds for regenerative therapy, and coating materials for titanium and/or zirconia similar to Hydroxyapatite and Titanium.