Novel Biocompatible Amino Acids-Functionalized Three-dimensional Graphene Foams: As the Attractive and Promising Cisplatin Carriers for Sustained Release Goals

Ezzati, Nasim; Mahjoub, Ali Reza; Shokrollahi, Sudabeh; Amiri, Ahmad; Shahrnoy, Abdolghafar Abolhosseini

doi:10.1016/j.ijpharm.2020.119857

Cited by 19 publications

(7 citation statements)

References 88 publications

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“…In a different investigation, amino acids‐grafted graphene aerogel were fabricated by anchoring three amino acids including Alanine, Cysteine, and Glycine on the surface of aerogel nanostructures, which then used for cisplatin delivery. [ 135 ] The authors were able to enhance both drug loading amount and the rate of drug releasing upon functionalization process, the large surface area of amino acid aerogel allowed higher loading content, which was clearly observed in Alanine‐based aerogel. The biocompatibility of the amino acid‐grafted graphene aerogel was evaluated on two human cancer cell lines (MCF‐7 and HepG2).…”

Section: Biopolymers Based Aerogels In Anticancer Drug Delivery Appli...mentioning

confidence: 95%

Revolutionizing Cancer Treatment: Biopolymer‐Based Aerogels as Smart Platforms for Targeted Drug Delivery

Alkhalidi,

Alahmadi,

Rizg

et al. 2024

Macromol. Rapid Commun.

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Cancer stands as a leading cause of global mortality, with chemotherapy being a pivotal treatment approach, either alone or in conjunction with other therapies. The primary goal these therapies is to inhibit the growth of cancer cells specifically, while minimizing harm to healthy dividing cells. Conventional treatments have been hampered by their side effects, often causing severe discomfort to patients. Researchers have been exploring innovative approaches to target cancer cells selectively. In this context, biopolymer‐based aerogels emerge as innovative platforms, showcasing unique properties that respond intelligently to diverse stimuli, including temperature, pH variations, magnetic fields, and redox potential. This responsiveness enables precise control over the release of anticancer drugs, enhancing therapeutic outcomes. The significance of these aerogels lies in their ability to offer targeted drug delivery with increased efficacy, biocompatibility, and a high drug payload. In this comprehensive review, we discuss the role of biopolymer‐based aerogels as an emerging functionalized platforms in anticancer drug delivery. The review addresses the unique properties of biopolymer‐based aerogels showing their smart behavior in responding to different stimuli including temperature, pH, magnetic and redox potential to control anticancer drug release. Finally, the review discusses the application of different biopolymer‐based aerogel in delivering different anticancer drugs and also discusses the potential of these platforms in gene delivery applications. This article is protected by copyright. All rights reserved

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Section: Biopolymers Based Aerogels In Anticancer Drug Delivery Appli...mentioning

confidence: 95%

Revolutionizing Cancer Treatment: Biopolymer‐Based Aerogels as Smart Platforms for Targeted Drug Delivery

Alkhalidi,

Alahmadi,

Rizg

et al. 2024

Macromol. Rapid Commun.

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“…Functionalization of GO with alanine resulted in a pronouncedly higher amount of loaded CDDP and drug-releasing rate compared to GO foams functionalized with cysteine and glycine due to larger surface area and pore volume of alanine-GO foam and a test with MCF-7 and HepG2 human cancer cell lines showed satisfactory biocompatibility and sustainable CDDP release up to 48 h [210]. GO@peptide hybrids fabricated through irreversible physical adsorption of the Ac-(GHHPH) 4 -NH 2 peptide sequence, known to mimic the anti-angiogenic domain of the histidine-proline-rich glycoprotein, showed powerful toxicity to PC-3 prostate cells, effectively inhibited the cell migration, and inhibited the prostaglandin-mediated inflammatory process not only in PC-3 cells but also in human retinal endothelial cells.…”

Section: Functionalized Gomentioning

confidence: 99%

Advances in Drug Delivery Nanosystems Using Graphene-Based Materials and Carbon Nanotubes

2021

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Carbon is one of the most abundant elements on Earth. In addition to the well-known crystallographic modifications such as graphite and diamond, other allotropic carbon modifications such as graphene-based nanomaterials and carbon nanotubes have recently come to the fore. These carbon nanomaterials can be designed to help deliver or target drugs more efficiently and to innovate therapeutic approaches, especially for cancer treatment, but also for the development of new diagnostic agents for malignancies and are expected to help combine molecular imaging for diagnosis with therapies. This paper summarizes the latest designed drug delivery nanosystems based on graphene, graphene quantum dots, graphene oxide, reduced graphene oxide and carbon nanotubes, mainly for anticancer therapy.

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“…Functionalized graphene foams have shown potential as biosensors for detecting specific biomarkers due to their high sensitivity and biocompatibility [139]. Additionally, their large surface area can facilitate the loading and delivery of therapeutic agents in drug delivery systems [140]. However, further research is needed to understand the biocompatibility and long-term effects of graphene foams in biological environments.…”

Section: Graphene Foamsmentioning

confidence: 99%

Emerging Trends in Nanomedicine: Carbon-Based Nanomaterials for Healthcare

Parvin,

Kumar,

Joo

et al. 2024

Nanomaterials

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Carbon-based nanomaterials, such as carbon quantum dots (CQDs) and carbon 2D nanosheets (graphene, graphene oxide, and graphdiyne), have shown remarkable potential in various biological applications. CQDs offer tunable photoluminescence and excellent biocompatibility, making them suitable for bioimaging, drug delivery, biosensing, and photodynamic therapy. Additionally, CQDs’ unique properties enable bioimaging-guided therapy and targeted imaging of biomolecules. On the other hand, carbon 2D nanosheets exhibit exceptional physicochemical attributes, with graphene excelling in biosensing and bioimaging, also in drug delivery and antimicrobial applications, and graphdiyne in tissue engineering. Their properties, such as tunable porosity and high surface area, contribute to controlled drug release and enhanced tissue regeneration. However, challenges, including long-term biocompatibility and large-scale synthesis, necessitate further research. Potential future directions encompass theranostics, immunomodulation, neural interfaces, bioelectronic medicine, and expanding bioimaging capabilities. In summary, both CQDs and carbon 2D nanosheets hold promise to revolutionize biomedical sciences, offering innovative solutions and improved therapies in diverse biological contexts. Addressing current challenges will unlock their full potential and can shape the future of medicine and biotechnology.

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Novel Biocompatible Amino Acids-Functionalized Three-dimensional Graphene Foams: As the Attractive and Promising Cisplatin Carriers for Sustained Release Goals

Cited by 19 publications

References 88 publications

Revolutionizing Cancer Treatment: Biopolymer‐Based Aerogels as Smart Platforms for Targeted Drug Delivery

Revolutionizing Cancer Treatment: Biopolymer‐Based Aerogels as Smart Platforms for Targeted Drug Delivery

Advances in Drug Delivery Nanosystems Using Graphene-Based Materials and Carbon Nanotubes

Emerging Trends in Nanomedicine: Carbon-Based Nanomaterials for Healthcare

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