Novel Biomarkers Predictive of Diabetic Charcot Foot—An Overview of the Literature

Bobircă, Anca; Mușetescu, Anca Emanuela; Bordianu, Anca; Stoian, Anca Pantea; Salmen, Teodor; Marinescu, Dan-Cristian; Alexandru, Cristina; Florescu, Anamaria; Radu, Raluca Nicoleta; Isac, Sebastian; Pătraşcu, T; Serban, Dragos; Bobircă, Florin

doi:10.3390/life12111944

Cited by 2 publications

(1 citation statement)

References 51 publications

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“…Although not as prevalent as complications it poses a significant risk due to its debilitating consequences. The development of Charcot foot involves a combination of neuropathy that impairs autonomic functions and an abnormal inflammatory response (4). This leads to bone demineralization and joint damage exacerbated by injuries that go unnoticed due to diminished sensation.…”

Section: Introductionmentioning

confidence: 99%

Orthopedic Complications in Diabetes: Charcot Foot, Neuropathy, and Surgical Considerations

Aborukbah,

Alghamdi,

Elbashir

et al. 2023

JOHS

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Orthopedic problems in individuals with diabetes are complex and challenging to handle. Among these issues, Charcot foot stands out as a debilitating condition characterized by joint destruction and deformities. This condition is closely linked to neuropathy and inflammation, leading to bone weakening and joint damage. Unfortunately, Charcot foot often goes unnoticed until significant complications arise, underscoring the importance of recognition and intervention. Diabetic neuropathy, affecting around half of all people with diabetes, further complicates challenges by causing loss, autonomic dysfunction and muscle weakness. Sensory loss in the feet puts individuals at risk for injuries, ulcers, and other complications. The diverse symptoms associated with neuropathy impact patients daily. Require individualized management strategies. Surgical considerations in patients add a layer of complexity to their care. Thorough preoperative assessments, infection control measures, vascular evaluations and careful postoperative monitoring are crucial for surgical management. Collaboration among healthcare professionals from specialties is vital for optimizing outcomes. Effective management strategies for these complications involve offloading pressure on affected areas to prevent injury or trauma, maintaining tight glycemic control to minimize complications, providing pain relief to alleviate discomforts experienced by patients and implementing rehabilitation programs that enhance functionality. It is crucial to prioritize identification, prompt intervention, and thorough patient education to achieve results and enhance the overall well-being of individuals with diabetes. To summarize, managing orthopedic issues in patients necessitates a comprehensive strategy that takes into account the complexities of Charcot foot diabetic neuropathy and surgical treatments.

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Section: Introductionmentioning

confidence: 99%

Orthopedic Complications in Diabetes: Charcot Foot, Neuropathy, and Surgical Considerations

Aborukbah,

Alghamdi,

Elbashir

et al. 2023

JOHS

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Histomorphometrical features of the ankle synovium in diabetic neuroosteoarthropathy complicated by chronic osteomyelitis

Stupina,

Mezentsev

2024

Žurnal anatomii i gistopatologii

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The role of the synovium in the pathogenesis of the Charcot foot is not properly studied; there is no information on its histomorphometric features. The aim of the study was to investigate the histomorphometric features of the synovial membrane in patients with diabetic neuroosteoarthropathy complicated by chronic osteomyelitis. Material and methods. Osteochondral fragments and fragments of the articular capsule of the ankle joint obtained from 35 patients were examined. Group 1 included patients with diabetic neuroosteoarthropathy accompanied by chronic osteomyelitis in the acute stage (n=26). Group 2 included patients suffering from diabetic neuroosteoarthropathy with chronic osteomyelitis in remission (n=9). The control group included individuals who did not suffer from diabetes mellitus and diseases of the musculoskeletal system (n = 7); the synovial membrane obtained during their autopsy was used for comparison. Histomorphometry was performed on paraffin and semi-thin sections stained with hematoxylin and eosin, as well as Masson trichrome stain, using an AxioScope.A1 microscope and Zenblue software (Carl Zeiss MicroImaging GmbH, Germany). Results. In patients of group 1, high-grade synovitis and hyperplasia of the integumentary layer were registered. In patients of group 2, mild synovitis and fibrosis of the integumentary layer were noted. In both groups, histological signs of microcirculation disorders were revealed. In the 1st group, there was an increase in the thickness of the covering layer by 1.5 times compared to the control; in the 2nd group, the values of this parameter were 1.7 times lower compared to the control parameters. In both groups, an increase in the numerical density of microvasculature vessels was recorded, being the most pronounced in patients of Group 1. Conclusion. A histomorphometric study of the synovial membrane of the ankle joints in patients with diabetic neuroosteoarthropathy allowed identifying a number of features of its restructuring in the form of reactive and degenerative-inflammatory changes at different inflammatory stages of chronic osteomyelitis.

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Novel Biomarkers Predictive of Diabetic Charcot Foot—An Overview of the Literature

Cited by 2 publications

References 51 publications

Orthopedic Complications in Diabetes: Charcot Foot, Neuropathy, and Surgical Considerations

Orthopedic Complications in Diabetes: Charcot Foot, Neuropathy, and Surgical Considerations

Histomorphometrical features of the ankle synovium in diabetic neuroosteoarthropathy complicated by chronic osteomyelitis

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