Novel chewable colon targeted tablets of bumadizone calcium for treatment of ulcerative colitis: Formulation and optimization

Nour, Samia A.; Abdelmalak, Nevine Shawky; Naguib, Marianne J.

doi:10.1016/j.jddst.2016.06.001

Cited by 8 publications

(2 citation statements)

References 39 publications

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“…The key excipients in chewable tablets include flavouring agents and sweeteners because they are intended to be chewed, and it is necessary to mask unpleasant tastes. Like other types of tablets, conventional manufacturing methods, such as wet or dry granulation [47,48] and direct compression [49], are used for the preparation of chewable tablets (Figure 2). The main advantages of using direct compression are its lower costs due to the fewer steps involved, the absence of a drying step, its suitability for moisture-and heat-sensitive drugs, and lower chances for microbial growth or cross-contamination [50,51].…”

Section: Chewable Tabletsmentioning

confidence: 99%

Innovations in Chewable Formulations: The Novelty and Applications of 3D Printing in Drug Product Design

et al. 2022

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Since their introduction, chewable dosage forms have gained traction due to their ability to facilitate swallowing, especially in paediatric, geriatric and dysphagia patients. Their benefits stretch beyond human use to also include veterinary applications, improving administration and palatability in different animal species. Despite their advantages, current chewable formulations do not account for individualised dosing and palatability preferences. In light of this, three-dimensional (3D) printing, and in particular the semi-solid extrusion technology, has been suggested as a novel manufacturing method for producing customised chewable dosage forms. This advanced approach offers flexibility for selecting patient-specific doses, excipients, and organoleptic properties, which are critical for ensuring efficacy, safety and adherence to the treatment. This review provides an overview of the latest advancements in chewable dosage forms for human and veterinary use, highlighting the motivations behind their use and covering formulation considerations, as well as regulatory aspects.

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Section: Chewable Tabletsmentioning

confidence: 99%

Innovations in Chewable Formulations: The Novelty and Applications of 3D Printing in Drug Product Design

et al. 2022

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“…On the other hand, in order to resist the damage caused by acidic gastric fluid, drugs are usually protected with acid-resistant coating materials, including cellulose and its derivatives, polyacrylates, ethylene polymers, etc., among which Eudragit L100 and S100 are widely used in various enteric-coated materials. For instance, Nour et al [27] prepared chewable colon-targeted tablets by mixing Eudragit L100 and S100 with bumadizone calcium drugs. However, this purely physical mixing method can only be used with a limited range of loaded drugs.…”

Section: Introductionmentioning

confidence: 99%

Preparation of Multifunctional Drug‐loaded Microcapsules with Core‐shell Three‐dimensional Network Structure and their Application in Colon Targeted Release

et al. 2021

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Some special oral drugs may cause adverse reactions and degrade in the stomach; therefore, it is necessary to develop a new generation of multifunctional drug delivery carries to deal with such issues. Herein, by polyelectrolyte composite method using KGM and CS as raw material, CKGM/CS/TPP/5‐ASA microcapsules are prepared using 5‐ASA as model drug, and then coated with an acid‐resistant polyacrylic acid polymer layer. The size of CKGM/CS/TPP/5‐ASA microcapsules is relatively uniform, with average particle size 1.78 ± 0.02 mm. The inner part of microcapsules has a core‐shell three‐dimensional network structure, and the 5‐ASA embedded in the network is in its crystal form. The microcapsules exhibited good encapsulate properties, with 495.5 µg mg−1 drug loading amount and 82.3% encapsulation efficiency under optimized conditions. The in vitro release properties of microcapsules are also studied, and results showed that the drug is released little in Simulated Gastric Fluid solution (pH 1.2) but fully released in Simulated Colonic Fluid or Phosphate Buffered Solution (pH 7.0), and the release rate is higher in SCF solution, indicating that β‐mannanase could facilitate release. All these results indicated that CKGM/CS/TPP microcapsules have good pH‐controlled release, enzymatic release, and sustained release properties, hence they are promising multifunctional colon‐targeted release carriers.

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Development and in vivo evaluation of chitosan beads for the colonic delivery of azathioprine for treatment of inflammatory bowel disease

Helmy

Elsabahy

Soliman

et al. 2017

European Journal of Pharmaceutical Sciences

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Novel chewable colon targeted tablets of bumadizone calcium for treatment of ulcerative colitis: Formulation and optimization

Cited by 8 publications

References 39 publications

Innovations in Chewable Formulations: The Novelty and Applications of 3D Printing in Drug Product Design

Innovations in Chewable Formulations: The Novelty and Applications of 3D Printing in Drug Product Design

Preparation of Multifunctional Drug‐loaded Microcapsules with Core‐shell Three‐dimensional Network Structure and their Application in Colon Targeted Release

Development and in vivo evaluation of chitosan beads for the colonic delivery of azathioprine for treatment of inflammatory bowel disease

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