Novel Chitin and Chitosan Materials in Wound Dressing

Jayakumar, R.; Prabaharan, M.; Kumar, P.T. Sudheesh; Nair, Shanti V.; Furuike, Tetsuya; Tamura, Hiroshi

doi:10.5772/13509

Cited by 27 publications

(20 citation statements)

References 97 publications

(121 reference statements)

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“…The BC/COL hydrogel promoted a macroscopically better result of tissue repair in relation to wound dressing based on dextran hydrogel 48 , whereas the histological analysis showed similar results in comparison to the hydrogel based on chitin 49 . It also exhibited most of the desirable characteristics for an 'ideal dressing', was suitable for the cleansing of dry wounds and promoted autolytic debridement.…”

Section: In Vivo Experimentsmentioning

confidence: 56%

Bacterial Cellulose/Collagen Hydrogel for Wound Healing

Moraes¹,

et al. 2016

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This study compares a wound dressing based on bacterial cellulose/collagen (BC/COL) hydrogel in rat dorsum with commercial collagenase ointment and untreated wound. The hydrogel was characterized by Scanning Electron Microscopy (SEM), Thermogravimetric Analysis (TGA), Fourier transformed -Infrared spectroscopy (FT-IR) and X-ray diffraction (XRD). According to the In vivo test and macroscopic evaluation, BC/COL hydrogel showed a better repair of wounds and promoted statistically significant differences of tissue repair between treatments on the 7th day after surgery. Better quality, quantity and orientation evaluation of collagen fibers (p=0.0001) were observed in the BC/COL hydrogel and collagenase ointment groups in relation to the control group. The BC/COL hydrogel promoted better wound healing than collagenase and the control group, therefore, it can be considered a potential wound dressing for skin regeneration.

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Section: In Vivo Experimentsmentioning

confidence: 56%

Bacterial Cellulose/Collagen Hydrogel for Wound Healing

Moraes¹,

et al. 2016

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“…Cell proliferation is promoted and it aids in histoarchitectural tissue organization. Chitosan is a hemostat, which aids in natural clotting of blood reduces pain by blocking nerve endings, [11] thereby yielding significant NRS scores in our study. Chitosan gradually depolymerizes to release N-acetyl-D-glucosamine, the following which fibroblast proliferation is initiated, thereby aiding in ordered collagen deposition and increases the synthesis of natural hyaluronic acid at the wound site.…”

Section: Discussionmentioning

confidence: 78%

“…It is biocompatible, biodegradable, nontoxic, anti-microbial, anti-fungal and a hydrating mucoadhesive agent. [11] Chitosan with beneficial biological and antimicrobial properties and high potential for wound healing is attractive for wound care. [12] Hence, a project was taken up to develop an effective occlusive mucoadhesive treatment system for the treatment of OM.…”

Section: Introductionmentioning

confidence: 99%

Use of chitosan mouth-wash in radio-chemotherapy induced oral mucositis: A case-control study

Mahima¹,

Patil²,

Kulkarni³

et al. 2015

JCRI

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Background: Oral mucositis (OM) is a common dose-limiting and potentially serious complication of radio-chemotherapy which leads to atrophy and ulceration of the mucosa and an increased risk of infection in immunosuppressed patients. Chitosan is a cationic polysaccharide commercially extracted from the shells of shrimps and crab. Chitosan has beneficial biological and antimicrobial properties with high potential for wound healing. It is biocompatible, biodegradable, non-toxic, anti-microbial, anti-fungal, and a hydrating mucoadhesive agent. Aims: To evaluate the efficacy and safety of chitosan mouthwash in the treatment of OM and if it could be used as a routine protocol for the treatment of OM. Subjects and Methods:The study was conducted on 20 patients (10 cases and 10 controls) diagnosed with OM following radiochemotherapy. The study group received 1% freshly prepared chitosan mouthwash, and the control group received chlorhexidine mouthwash. Signs and symptoms were assessed using numerical rating scale (NRS), the WHO and OM Assessment Scale at 0, 10 and 20 days. Statistical analysis: Descriptive statistics, Friedman's and Mann-Whitney U test were performed. Results: Statistically significant differences were seen in the NRS (P = 0), ulceration (P = 0.007), and WHO (P = 0.029) scores. Conclusions: Chitosan was found to be a more effective than chlorhexidine in the alleviation of symptoms of OM.

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“…Industrially, chitosan is usually produced by de-N-acetylation of chitin. When the degree of Nacetylation is less than 50%, chitin becomes soluble in aqueous acidic solutions (pH < 6.0) and is called chitosan [3,4,5]. This means that chitosan represents a group of fully and partially deacetylated chitins, but a rigid nomenclature with respect to the degree of Ndeacetylation between chitin and chitosan has not been established [6].…”

Section: Introductionmentioning

confidence: 99%

Utilization of Shrimp Skin Waste (Sea Lobster) As Raw Material for the Membrane Filtration

Sumadiyasa

Suyanto

Windari

2017

J. Phys.: Conf. Ser.

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Abstract. In view of the increasing littering of the sea banks by shells of crustaceans, a study was carried out to investigate the extraction and characterization of chitosan from skin waste of sea lobster i.e. 'Bamboo Lobster' (Panulirus versicolor). Chitosan was extracted using conventional methods such as pretreatment, demineralization, deprotienization, and deacetylation. The result showed that the degree of deacetylation of chitosan obtained is 70.02%. The FTIR spectra of the chitosan gave a characteristic of -NH 2 band at 3447 cm -1 and carbonyl group band at 1655 cm -1 . This chitosan has been used to prepare membrane. The chitosan membrane 2% has been prepared using phase inversion method with precipitation by solvent evaporation. The membranes were characterized by FTIR spectrophotometer, Nova 1200e using BJH method, and filtration method. The results show that thickness of the membrane is about 134 µm. The FTIR spectra show that functional groups present in the membrane are -NH, -CH, C=O, and -OH. Using BJH method obtained that the pore diameter is 3.382 nm with pore density is 8.95 x 10 5 pores/m 3 . By filtration method obtained that pure water flux (PWF) of the membrane are 386.662 and 489.627 l/m 2 .h at pressure 80-85 kPa and 90-100 kPa, respectively. These results show that skin waste of sea lobster was discovered as a raw material to prepare chitosan membrane. The membrane obtained is belonged to mesoporous group which may use in microfiltration process.

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Novel Chitin and Chitosan Materials in Wound Dressing

Cited by 27 publications

References 97 publications

Bacterial Cellulose/Collagen Hydrogel for Wound Healing

Bacterial Cellulose/Collagen Hydrogel for Wound Healing

Use of chitosan mouth-wash in radio-chemotherapy induced oral mucositis: A case-control study

Utilization of Shrimp Skin Waste (Sea Lobster) As Raw Material for the Membrane Filtration

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