Novel Collagen Matrix to Increase Tissue Thickness Simultaneous with Guided Bone Regeneration and Implant Placement in Esthetic Implant Sites: A Feasibility Study

Chappuis, Vivianne; Shahim, K.; Buser, Ramona; Koller, Edi; Joda, Tim; Buser, Daniel

doi:10.11607/prd.3700

Cited by 12 publications

(8 citation statements)

References 29 publications

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“…Autogenous soft tissue graft procedures, including autogenous free gingival grafts and connective tissue grafts, are used as gold standard methods for soft tissue augmentation. Nevertheless, the disadvantages of autogenous soft tissue grafts include the possibility of volume shrinkage, morbidity, and the limitations of host tissues (Chappuis et al, ). Therefore, soft tissue substitutes, including allogeneic, xenogeneic, or alloplastic soft tissue substitutes, have been developed.…”

Section: Introductionmentioning

confidence: 99%

In vitro observation of macrophage polarization and gingival fibroblast behavior on three‐dimensional xenogeneic collagen matrixes

Fujioka‐Kobayashi

Ülgür

Katagiri

et al. 2020

J Biomedical Materials Res

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Collagen biomaterials are widely used for soft tissue augmentation. Cross‐linking techniques for collagen matrix (CM) achieve mechanical and volumetric stability; nevertheless, cross‐linking may compromise biocompatibility. The aim of the present study was to investigate two different three‐dimensional (3D) porcine‐derived CMs, noncross‐linked (ncl)_CM and cross‐linked (cl)_CM, for their effects on macrophages (Mφ) and gingival fibroblasts. The effects of the CMs on the cell viability, proliferation, and polarization of Mφ derived from human monocyte THP‐1 cells were assessed. The effects of paracrine factors from Mφ cultured on the CMs were further studied in human gingival fibroblasts (HGF‐1 cells). The spongy layer of ncl_CM was partially resorbed after 1 day of culture. cl_CM maintained increased numbers of viable cells when compared with ncl_CM on day 3 for both THP‐1 and HGF‐1 cells. Higher mRNA levels of M1 markers, including IL‐1 and IL‐6, were found in Mφ cultured on cl_CM, while no significant differences were observed in M2 marker expression levels, including Arg1 and CD206, for cells cultured on both CMs when compared with those of the control. Furthermore, the conditioned medium collected from Mφ cultured on both CMs decreased cell viability. Nevertheless, neither of the CM‐conditioned media influenced the mRNA levels of TGF‐β, COL1a2, and PDGF‐A in HGF‐1 cells when compared with the control media. A comparison showed that cl_CM tended to result in more viable cells than ncl_CM, while cl_CM polarized Mφ toward an M1 phenotype, which was confirmed by the observation of increased mRNA levels of pro‐inflammatory cytokines.

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Section: Introductionmentioning

confidence: 99%

In vitro observation of macrophage polarization and gingival fibroblast behavior on three‐dimensional xenogeneic collagen matrixes

Fujioka‐Kobayashi

Ülgür

Katagiri

et al. 2020

J Biomedical Materials Res

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“…Second, behavioral control was difficult in the experimental animals, unlike in human patients who became extremely careful after surgery. In a clinical prospective study, Chappuis and colleagues (2018) [ 32 ] performed simultaneous GBR and soft tissue volume augmentation using volume-stable collagen matrix, leading to 2.1 mm of tissue volume increase. Third, in the present canine study, the maxillary premolar region was chosen as the surgical site.…”

Section: Discussionmentioning

confidence: 99%

Immediate implant placement in conjunction with guided bone regeneration and/or connective tissue grafts: an experimental study in canines

Lim

Paeng

Kim

et al. 2022

J Periodontal Implant Sci

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Purpose: This study was conducted to assess the effect of hard and/or soft tissue grafting on immediate implants in a preclinical model. Methods: In 5 mongrel dogs, the distal roots of P2 and P3 were extracted from the maxilla (4 sites in each animal), and immediate implant placement was performed. Each site was randomly assigned to 1 of the following 4 groups: i) gap filling with guided bone regeneration (the GBR group), ii) subepithelial connective tissue grafting (the SCTG group), iii) GBR and SCTG (the GBR/SCTG group), and iv) no further treatment (control). Non-submerged healing was provided for 4 months. Histological and histomorphometric analyses were performed. Results: Peri-implant tissue height and thickness favored the SCTG group (height of periimplant mucosa: 1.14 mm; tissue thickness at the implant shoulder and ±1 mm from the shoulder: 1.14 mm, 0.78 mm, and 1.57 mm, respectively; median value) over the other groups. Bone grafting was not effective at the level of the implant shoulder and on the coronal level of the shoulder. In addition, simultaneous soft and hard tissue augmentation (the GBR/SCTG group) led to a less favorable tissue contour compared to GBR or SCTG alone (height of periimplant mucosa: 3.06 mm; thickness of peri-implant mucosa at the implant shoulder and ±1 mm from the shoulder: 0.72 mm, 0.3 mm, and 1.09 mm, respectively). Conclusion: SCTG tended to have positive effects on the thickness and height of the periimplant mucosa in immediate implant placement. However, simultaneous soft and hard tissue augmentation might not allow a satisfactory tissue contour in cases where the relationship between implant position and neighboring bone housing is unfavorable.

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“…Clinical data on procedures applying an EP protocol estimated that the soft tissue grafting accounted for more than 40% of the overall tissue volume (Schneider et al, 2011). Chappuis et al (2018) found that grafting with VCMX alongside EP (with simultaneous GBR) induced a 1.56‐mm increase in soft tissue thickness after 8 weeks . Another type of collagen matrix was very recently compared with CTG for EP (Schmitt et al, 2021), where CTG led to a larger gain of soft tissue volume compared with using a collagen matrix, with no statistically significant difference.…”

Section: Discussionmentioning

confidence: 99%

Dimensional ridge changes in conjunction with four implant timing protocols and two types of soft tissue grafts: A pilot pre‐clinical study

Lee

Shin

Hämmerle

et al. 2022

J Clinic Periodontology

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Aim: To determine the effect of (1) implant placement timing and (2) the type of soft tissue graft in terms of ridge profile changes.Materials and Methods: Four implant treatment modalities were applied in the mesial root areas of the third and fourth mandibular premolars of 10 mongrel dogs alongside connective-tissue graft (CTG) and volume-stable cross-linked collagen matrix (VCMX): immediate, early, and delayed placement (DP), and DP following alveolar ridge preservation (ARP). All dogs were sacrificed 3 months after soft tissue augmentation. Standard Tessellation Language files from designated time points were analysed.Results: Compared with the pre-extraction situation, the median width of the ridge demontstrated a linear increase only in group ARP/CTG (0.07 mm at the 2-mm level), whereas all other groups showed a reduction (between À1.87 and À0.09 mm, p > .05). Groups ARP/CTG (0.17 mm) and DP/CTG (0.05 mm) exhibited a profilometric tissue gain in a set region of interest (p > .05). The net effect of CTG and VCMX ranged from 0.14 to 0.79 mm. Conclusions: Dimensional ridge changes varied between treatment protocols. ARP with CTG led to the smallest difference in ridge profile between the pre-extraction and the study end time point. Both CTG and VCMX enhanced the ridge contour. K E Y W O R D S connective tissue graft, implant placement, tissue remodelling, volume-stable cross-linked collagen matrix Clinical Relevance Scientific rationale for study: Effects of implant placement timing (immediate placement, early placement, and delayed placement [DP] with or without alveolar ridge preservation [ARP]) and soft tissue augmentation types (connective-tissue graft [CTG]; volume-stable cross-linked collagen matrix [VCMX]) have previously been compared only among selected combinations. There has been no previous thorough investigation encompassing the various treatment modalities within a single model.

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Novel Collagen Matrix to Increase Tissue Thickness Simultaneous with Guided Bone Regeneration and Implant Placement in Esthetic Implant Sites: A Feasibility Study

Cited by 12 publications

References 29 publications

In vitro observation of macrophage polarization and gingival fibroblast behavior on three‐dimensional xenogeneic collagen matrixes

In vitro observation of macrophage polarization and gingival fibroblast behavior on three‐dimensional xenogeneic collagen matrixes

Immediate implant placement in conjunction with guided bone regeneration and/or connective tissue grafts: an experimental study in canines

Dimensional ridge changes in conjunction with four implant timing protocols and two types of soft tissue grafts: A pilot pre‐clinical study

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