Novel controlled ionic gelation strategy for chitosan nanoparticles preparation using TPP-β-CD inclusion complex

Pant, Anjali; Negi, Jeetendra Singh

doi:10.1016/j.ejps.2017.11.020

Cited by 62 publications

(29 citation statements)

References 39 publications

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“…Similar results were obtained by other authors in the encapsulation of insulin, magnetic ferrofluids, doxorubicin and ascorbyl palmitate . Looking for better and reproducible results of IG formulations, the technique has been studied in terms of nanoparticle mono‐dispersion, the conditions needed to reduce nanoparticle sizes and sustained drug release kinetics …”

Section: Most Used Species For Igsupporting

confidence: 64%

Ionotropic gelation method in the synthesis of nanoparticles/microparticles for biomedical purposes

Pedroso‐Santana

Fleitas‐Salazar

2020

Polymer International

167

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The encapsulation of drugs inside polymeric nanoparticles/microparticles is a strategy currently employed in the search for new and more effective therapies. The use of biocompatible and biodegradable polymers gives several advantages to these formulations. Protection of the active principals against the action of environmental and physiological agents, the reduced number of doses and a subsequent decrease in drug-related adverse effects, and increased bioavailability are some of these advantages. Several methods and materials are now used to synthesize nanoparticles/microparticles for biomedical applications, from carbon-derived structures to metallic and lipid particles. However, among the methods using polymers, ionotropic gelation is one of the more affordable and easier procedures to perform in daily laboratory work. In this mini-review, we address relevant characteristics of ionotropic gelation, beginning with basic aspects of the technique, which reagents and conditions are commonly used, the factors affecting the stability of the formulation, the advantages and disadvantages of the method and some principal characterization techniques for the nanoparticulate/microparticulate formulation. Finally, we conclude with a few important considerations.

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Section: Most Used Species For Igsupporting

confidence: 64%

Ionotropic gelation method in the synthesis of nanoparticles/microparticles for biomedical purposes

Pedroso‐Santana

Fleitas‐Salazar

2020

Polymer International

167

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“…1a) with a good PDI (0.320 AE 0.017) (n ¼ 3) demonstrating that the solution had good homogeneity. 34 Regarding the surface charge, the potential value of the inclusion complex was À27.7 AE 0.32 mV (n ¼ 3) (Fig. 1b), which supported the standpoint that the inclusion complex solution possesses stability because its particles exhibit sufficient interparticle repulsion to prevent aggregation.…”

Section: Dispersion Testsupporting

confidence: 59%

“…1b), which supported the standpoint that the inclusion complex solution possesses stability because its particles exhibit sufficient interparticle repulsion to prevent aggregation. 35 It was reported by Lu et al that when the zeta potential of a solution is high, a relatively stable system is achieved, because the repulsive force exceeds the attraction. 36,37 However, the potential value of À27.7 AE 0.32 mV is only in an acceptable potential range and is not exceptional.…”

Section: Dispersion Testmentioning

confidence: 99%

Construction of a water-soluble and photostable rubropunctatin/β-cyclodextrin drug carrier

Ren

et al. 2019

RSC Adv.

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“…A simple TEO/β-CD-IC is not effective against C. jejuni as β-CD has an electroneutral nature and its absorption onto negatively charged bacterial cell wall is limited. To address this issue ionic gelation was applied to adsorb cationic biopolymers onto the surface of TEO/ β-CD-IC [157]. In the study, ε-polylysine (ε-PLY), a biodegradable cationic biological metabolite with outstanding antibacterial properties, was selected to prepare TEO/β-CD ε-polylysine nanoparticles (TCPNs) [158].…”

Section: Encapsulation Of Yme Essential Oil (Teo) and Ymol (Thymentioning

confidence: 99%

Essential Oils-Loaded Electrospun Biopolymers: A Future Perspective for Active Food Packaging

Ataei

Azari

Hassan

et al. 2020

Advances in Polymer Technology

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The growth of global food demand combined with the increased appeal to access different foods from every corner of the globe is forcing the food industry to look for alternative technologies to increase the shelf life. Essential oils (EOs) as naturally occurring functional ingredients have shown great prospects in active food packaging. EOs can inhibit the growth of superficial food pathogens, modify nutritious values without affecting the sensory qualities of food, and prolong the shelf life when used in food packaging as an active ingredient. Since 2016, various reports have demonstrated that combinations of electrospun fibers and encapsulated EOs could offer promising results when used as food packaging. Such electrospun platforms have encapsulated either pure EOs or their complexation with other antibacterial agents to prolong the shelf life of food products through sustained release of active ingredients. This paper presents a comprehensive review of the essential oil-loaded electrospun fibers that have been applied as active food packaging material.

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Novel controlled ionic gelation strategy for chitosan nanoparticles preparation using TPP-β-CD inclusion complex

Cited by 62 publications

References 39 publications

Ionotropic gelation method in the synthesis of nanoparticles/microparticles for biomedical purposes

Ionotropic gelation method in the synthesis of nanoparticles/microparticles for biomedical purposes

Construction of a water-soluble and photostable rubropunctatin/β-cyclodextrin drug carrier

Essential Oils-Loaded Electrospun Biopolymers: A Future Perspective for Active Food Packaging

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