Novel coronavirus: From discovery to clinical diagnostics

Phan, Tung Gia

doi:10.1016/j.meegid.2020.104211

Cited by 258 publications

(252 citation statements)

References 8 publications

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“…Like other betacoronaviruses, the genome of SARS-CoV-2 has a long ORF1ab polyprotein at the 5′ end, followed by four major structural proteins, including the spike surface glycoprotein, small envelope protein, matrix protein, and nucleocapsid protein (Phan, 2020). Our genetic analysis discovered three deletions in the genomes of SARS-CoV-2 from Japan (Aichi), USA (Wisconsin), and Australia (Victoria) as shown in Fig.…”

Section: The Studymentioning

confidence: 80%

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Genetic diversity and evolution of SARS-CoV-2

Phan

2020

Infection, Genetics and Evolution

Self Cite

607

585

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A B S T R A C TCOVID-19 is a viral respiratory illness caused by a new coronavirus called SARS-CoV-2. The World Health Organization declared the SARS-CoV-2 outbreak a global public health emergency. We performed genetic analyses of eighty-six complete or near-complete genomes of SARS-CoV-2 and revealed many mutations and deletions on coding and non-coding regions. These observations provided evidence of the genetic diversity and rapid evolution of this novel coronavirus.

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Section: The Studymentioning

confidence: 80%

“…A new coronavirus SARS-CoV-2 is spreading cross the world (Phan, 2020). Since the virus emerged at the seafood wholesale market at the end of last year (Zhu et al, 2019), the number of infected cases has been rising dramatically (Velavan and Meyer, 2020).…”

Section: The Studymentioning

confidence: 99%

Genetic diversity and evolution of SARS-CoV-2

Phan

2020

Infection, Genetics and Evolution

Self Cite

607

585

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“…In 2010, Shi et al isolated a SARS-like coronavirus which was highly homologous to the SARS-CoV, confirming that Rhinolophus sinicus (Chinese rufous horseshoe bat) was a natural host of the SARS-CoV [46]. Bats are known to be hosts for 30 coronaviruses based on complete genomic sequences analysis [47]. Epidemiological investigations have shown that civet cats in the wildlife market were the direct source of SARS-CoV [48].…”

Section: Animal Reservoirsmentioning

confidence: 99%

“…CoV can enter host cells through the interaction between CoV S protein and its host receptor angiotensin-converting enzyme 2 (ACE2), which is isolated from SARS-CoV-permissive Vero-E6 cells. The receptor-binding motif (RBM) of S protein can directly contact ACE2 [47,101,102]. AEC2 have been identified to be key binding residues and functional receptor for SARS-CoV, and it can also protect alveolar cells [103].…”

Section: Pathogenic Mechanismsmentioning

confidence: 99%

Systematic Comparison of Two Animal-to-Human Transmitted Human Coronaviruses: SARS-CoV-2 and SARS-CoV

Zhao

Teng

et al. 2020

Viruses

646

622

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After the outbreak of the severe acute respiratory syndrome (SARS) in the world in 2003, human coronaviruses (HCoVs) have been reported as pathogens that cause severe symptoms in respiratory tract infections. Recently, a new emerged HCoV isolated from the respiratory epithelium of unexplained pneumonia patients in the Wuhan seafood market caused a major disease outbreak and has been named the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This virus causes acute lung symptoms, leading to a condition that has been named as "coronavirus disease 2019" (COVID-19). The emergence of SARS-CoV-2 and of SARS-CoV caused widespread fear and concern and has threatened global health security. There are some similarities and differences in the epidemiology and clinical features between these two viruses and diseases that are caused by these viruses. The goal of this work is to systematically review and compare between SARS-CoV and SARS-CoV-2 in the context of their virus incubation, originations, diagnosis and treatment methods, genomic and proteomic sequences, and pathogenic mechanisms.

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“…Viral diagnostics is an important role in this battle to SARS-CoV-2. However, due to the conduction of diagnostic testing for SARS-CoV-2 only at CDC and the strain of spectrum of the available diagnostic tools for this newly discovered virus at this time (Phan, 2020) , imaging examination is one of the quick and convenient methods to diagnosis and monitor disease progress during treatment. Nevertheless, imaging findings of pneumonia caused by viruses can be completely different, sometimes overlapping with other infectious and inflammatory diseases.…”

Section: Introductionmentioning

confidence: 99%

Epidemiological, clinical characteristics of cases of SARS-CoV-2 infection with abnormal imaging findings

Zhang¹,

Cai²,

Hu³

et al. 2020

International Journal of Infectious Diseases

266

240

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J o u r n a l P r e -p r o o f 2 (Lanjuan Li); yidayang65@zju.edu.cn (Yida Yang) Highlight  COVID-19 has be a great threat to world health.  We aim to investigate clinical features of patients with abnormal imaging findings.  Those with abnormal images have more obvious clinical and laboratory features.  Combing clinical data with imaging score can predict severe/critical type. AbstractPurpose: To investigate the epidemiological, clinical characteristics of COVID-19 patients with abnormal imaging findings. Methods: Patients confirmed with SARS-CoV-2 infection of Zhejiang province fromJan 17 to Feb 8 underwent CT or x-ray were enrolled. Epidemiological, clinical data were analyzed between those with abnormal or normal imaging findings.Results: Excluding 72 patients with normal images, 230 of 573 patients affected more than two lobes. The median radiograph score was 2.0 and there's negative correlation between the score and oxygenation index (ρ=-0.657, P<0.001). Patients with abnormal images were older (46.65±13.82), with higher rate of coexisting condition(28.8%), lower rate of exposure history and longer time between onset and confirmation(5d) than non-pneumonia patients(all P<0.05). Higher rate of fever, cough, expectoration, and headache, lower lymphocytes, albumin, serum sodium levels and higher total bilirubin, creatine kinase, lactate dehydrogenase and C-reactive J o u r n a l P r e -p r o o f 3 protein levels and lower oxygenation index were observed in pneumonia patients (all P<0.05). Muscle ache, shortness of breath, nausea and vomiting, lower lymphocytes levels and higher serum creatinine and radiograph score at admission were predictive factors for severe/critical subtype. Conclusion:Patients with abnormal images have more obvious clinical manifestations and laboratory changes. Combing clinical features and radiograph score can effectively predict severe/critical type.

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Novel coronavirus: From discovery to clinical diagnostics

Cited by 258 publications

References 8 publications

Genetic diversity and evolution of SARS-CoV-2

Genetic diversity and evolution of SARS-CoV-2

Systematic Comparison of Two Animal-to-Human Transmitted Human Coronaviruses: SARS-CoV-2 and SARS-CoV

Epidemiological, clinical characteristics of cases of SARS-CoV-2 infection with abnormal imaging findings

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