Novel, degradable, and cytoactive bone cements based on magnesium polyphosphate and calcium citrate

Ouyang, Yalan; Zhang, Rongguang; Chen, Hong; Chen, Lichao; Xi, Wenjing; Li, Xiaodan; Zhang, Qiyi; Yan, Yonggang

doi:10.1039/d2nj01706g

Cited by 4 publications

(5 citation statements)

References 61 publications

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“…Biodegradable material systems have been shown to benefit surgical patients, and our keyword analysis revealed that the terms "corrosion" and "mechanical-properties" were the most frequently used. The rate of corrosion is a crucial factor in the successful application of biodegradable materials for biomedical applications (Ouyang et al,2022). The complex service environment There are also different requirements for the degradation behavior of implants during the various stages of bone tissue repair (Rola et al,2022).…”

Section: Discussionmentioning

confidence: 99%

Global trends in the research of biodegradable biomedical magnesium-based materials: a bibliometric analysis

Zhu,

Liu,

et al. 2023

Front. Mater.

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Background: In recent years, there has been a notable surge in the interest surrounding biodegradable materials, particularly in the context of biomedical applications. This has led to a significant rise in the number of research studies focusing on the utilization of biodegradable magnesium-based materials in the field of biomedicine. However, a dearth of comprehensive assessment exists regarding the body of research concerning biodegradable biomedical magnesium-based materials. In this study, a bibliometric approach was used to illustrate the current state of research and global trends pertaining to biodegradable magnesium-based materials for biomedical applications.Methods: We conducted a search of the Web of Science core collection database for the past decade (2013–2022). VOSviewer software and the bibliometric online analysis platform were employed for bibliometric analysis and visualization.Results: Correspondingly, 1267 documents were retrieved. We discovered that the number of papers in the field of degradable biomedical magnesium-based materials research has increased annually. In addition, China and the Chinese Academy of Sciences have published the largest number of papers in the field of biodegradable biomedical magnesium-based materials. Papers related to biodegradable magnesium-based materials for biomedical use were mainly published in acta biomaterialia, materials science and engineering c-materials for biological applications and materials journals. Keyword co-occurrence analysis showed that “corrosion"and “mechanical-properties” appear more frequently. The top 10 common keywords include corrosion, mechanical-properties, microstructure, biocompatibility, behavior, magnesium, magnesium alloys, degradation magnesium alloy, in vitro.Conclusion: Research on biodegradable magnesium-based materials for biomedical use continues to increase steadily. China maintains a leading position in the world, and the Chinese Academy of Sciences represents a notable contribution to the research of biodegradable magnesium-based materials for biomedical use. Subsequently, “corrosion” and “mechanical-properties” were identified as the current research hotspots in the area of biodegradable biomedical magnesium-based materials.

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Section: Discussionmentioning

confidence: 99%

Global trends in the research of biodegradable biomedical magnesium-based materials: a bibliometric analysis

Zhu,

Liu,

et al. 2023

Front. Mater.

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“…MPP was fabricated referring to the literature [28,35]. The mass ratio of α-CSH, MPP, and C 3 S was optimized, and a final ratio of 87:10:3 in the preparation of CS/MPP/C 3 S composite bone cement was obtained.…”

Section: Preparation and Optimizing Of Cs/mpp/c 3 S Composite Bone Ce...mentioning

confidence: 99%

“…Within bone and cartilage tissues, PolyP acts as a regulator of gene expression, promotes the acceleration of osteoblast mineralization, and inhibits the differentiation of osteoblast precursors into osteoclasts [23][24][25][26]. Additionally, PolyP can form crosslinks with Mg 2+ , further promoting bone formation through ionic bonds at neutral pH [27][28][29]. Therefore, MPP holds promise in enhancing the bioactivity of CSC and fostering bone formation.…”

Section: Introductionmentioning

confidence: 99%

A Bioactive Degradable Composite Bone Cement Based on Calcium Sulfate and Magnesium Polyphosphate

Peng,

Yang,

Zou

et al. 2024

Materials

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Calcium sulfate bone cement (CSC) is extensively used as a bone repair material due to its ability to self-solidify, degradability, and osteogenic ability. However, the fast degradation, low mechanical strength, and insufficient biological activity limit its application. This study used magnesium polyphosphate (MPP) and constructed a composite bone cement composed of calcium sulfate (CS), MPP, tricalcium silicate (C3S), and plasticizer hydroxypropyl methylcellulose (HPMC). The optimized CS/MPP/C3S composite bone cement has a suitable setting time of approximately 15.0 min, a compressive strength of 26.6 MPa, and an injectability of about 93%. The CS/MPP/C3S composite bone cement has excellent biocompatibility and osteogenic capabilities; our results showed that cell proliferation is up to 114% compared with the control after 5 days. After 14 days, the expression levels of osteogenic-related genes, including Runx2, BMP2, OCN, OPN, and COL-1, are about 1.8, 2.8, 2.5, 2.2, and 2.2 times higher than those of the control, respectively, while the alkaline phosphatase activity is about 1.7 times higher. Therefore, the CS/MPP/C3S composite bone cement overcomes the limitations of CSC and has more effective potential in bone repair.

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“…It is known that degradable bone cements can fill and repair bone defects to promote bone regeneration [ 71 ]. However, they will be gradually degraded as a foreign matter in implanted bones after implantation into the human body.…”

Section: The Mechanism Of Degradabilitymentioning

confidence: 99%

Biodegradable Cements for Bone Regeneration

Liu

Cui

Chen

et al. 2023

JFB

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Bone cements such as polymethyl methacrylate and calcium phosphates have been widely used for the reconstruction of bone. Despite their remarkable clinical success, the low degradation rate of these materials hampers a broader clinical use. Matching the degradation rate of the materials with neo bone formation remains a challenge for bone-repairing materials. Moreover, questions such as the mechanism of degradation and how the composition of the materials contribute to the degradation property remain unanswered. Therefore, the review provides an overview of currently used biodegradable bone cements such as calcium phosphates (CaP), calcium sulfates and organic-inorganic composites. The possible degradation mechanism and clinical performance of the biodegradable cements are summarized. This paper reviews up-to-date research and applications of biodegradable cements, hoping to provide researchers in the field with inspirations and references.

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Novel, degradable, and cytoactive bone cements based on magnesium polyphosphate and calcium citrate

Abstract: Ideal bone-filling materials should be degradable and efficient for fast bone remodeling. In this study, magnesium polyphosphate was applied to bone cement for the first time and a novel degradable...

Cited by 4 publications

References 61 publications

Global trends in the research of biodegradable biomedical magnesium-based materials: a bibliometric analysis

Global trends in the research of biodegradable biomedical magnesium-based materials: a bibliometric analysis

A Bioactive Degradable Composite Bone Cement Based on Calcium Sulfate and Magnesium Polyphosphate

Biodegradable Cements for Bone Regeneration

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