Novel device to trend impedance and fluorescence of the cervix for preterm birth detection

Etemadi, Mozziyar; Chung, Philip; Heller, J. Alex; Liu, Jonathan; Grossman-Kahn, Rebecca; Rand, Larry; Roy, Shuvo

doi:10.1109/embc.2013.6609466

“…The authors concluded that the device was not “sufficiently accurate to justify clinical use”, 43 although impedance is currently being investigated longitudinally with a novel device that can be worn like a pessary on the cervix. 44…”

Section: Quantifying Cervical Remodelingmentioning

confidence: 99%

New techniques in evaluation of the cervix

Feltovich

¹

,

Carlson

²

2017

Seminars in Perinatology

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The process of parturition is poorly understood, but the cervix clearly plays a key role. Because of this, recent research efforts have been directed at objective quantification of cervical remodeling. Investigation has focused on two basic areas: (1) quantification of tissue deformability and (2) presence, orientation, and/or concentration of microstructural components (e.g. collagen). Methods to quantify tissue deformability include strain elastography and shear wave elasticity imaging (SWEI). Methods to describe tissue microstructure include attenuation and backscatter. A single parameter is unlikely to describe the complexities of cervical remodeling, but combining related parameters should improve accuracy of cervical evaluation. This chapter reviews options for cervical tissue characterization.

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“…Specific use of this device is described in Etemadi et al 12,13 . The mold used to create the intravaginal probe was fabricated from ABS430 material using a Dimension uPrint Plus 3D printer.…”

Section: Representative Resultsmentioning

confidence: 99%

Rapid and Low-cost Prototyping of Medical Devices Using 3D Printed Molds for Liquid Injection Molding

Chung

¹

,

Heller

²

,

Etemadi

³

et al. 2014

JoVE

Self Cite

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Biologically inert elastomers such as silicone are favorable materials for medical device fabrication, but forming and curing these elastomers using traditional liquid injection molding processes can be an expensive process due to tooling and equipment costs. As a result, it has traditionally been impractical to use liquid injection molding for low-cost, rapid prototyping applications. We have devised a method for rapid and low-cost production of liquid elastomer injection molded devices that utilizes fused deposition modeling 3D printers for mold design and a modified desiccator as an injection system. Low costs and rapid turnaround time in this technique lower the barrier to iteratively designing and prototyping complex elastomer devices. Furthermore, CAD models developed in this process can be later adapted for metal mold tooling design, enabling an easy transition to a traditional injection molding process. We have used this technique to manufacture intravaginal probes involving complex geometries, as well as overmolding over metal parts, using tools commonly available within an academic research laboratory. However, this technique can be easily adapted to create liquid injection molded devices for many other applications.

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“…The mold and intravaginal probe in Figures 14 and 15 demonstrates representative results of the procedure presented in this article. Specific use of this device is described in Etemadi et al 12,13 . The mold used to create the intravaginal probe was fabricated from ABS430 material using a Dimension uPrint Plus 3D printer.…”

Section: Representative Resultsmentioning

confidence: 99%

Rapid and Low-cost Prototyping of Medical Devices Using 3D Printed Molds for Liquid Injection Molding

Chung

¹

,

Heller

²

,

Etemadi

³

et al. 2014

JoVE

View full text Add to dashboard Cite

Biologically inert elastomers such as silicone are favorable materials for medical device fabrication, but forming and curing these elastomers using traditional liquid injection molding processes can be an expensive process due to tooling and equipment costs. As a result, it has traditionally been impractical to use liquid injection molding for low-cost, rapid prototyping applications. We have devised a method for rapid and low-cost production of liquid elastomer injection molded devices that utilizes fused deposition modeling 3D printers for mold design and a modified desiccator as an injection system. Low costs and rapid turnaround time in this technique lower the barrier to iteratively designing and prototyping complex elastomer devices. Furthermore, CAD models developed in this process can be later adapted for metal mold tooling design, enabling an easy transition to a traditional injection molding process. We have used this technique to manufacture intravaginal probes involving complex geometries, as well as overmolding over metal parts, using tools commonly available within an academic research laboratory. However, this technique can be easily adapted to create liquid injection molded devices for many other applications.

show abstract

Novel device to trend impedance and fluorescence of the cervix for preterm birth detection

Cited by 6 publications

References 29 publications

New techniques in evaluation of the cervix

New techniques in evaluation of the cervix

Rapid and Low-cost Prototyping of Medical Devices Using 3D Printed Molds for Liquid Injection Molding

Rapid and Low-cost Prototyping of Medical Devices Using 3D Printed Molds for Liquid Injection Molding

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