Novel Drug Delivery Systems for Modulation of Gastrointestinal Transit Time

Javadzadeh, Yousef; Hamedeyazdan, Sanaz

doi:10.5772/50250

Cited by 7 publications

(4 citation statements)

References 51 publications

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“…The human gastrointestinal ( GI ) tract (adapted from Ref. ). The upper GI tract consists of the esophagus, stomach, and the duodenum, while the lower GI tract consists of the small intestine, the large intestine, and the rectal region.…”

Section: State Of the Art In Research And Developmentmentioning

confidence: 99%

Magnetically guided capsule endoscopy

et al. 2017

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Wireless capsule endoscopy (WCE) is a powerful tool for medical screening and diagnosis, where a small capsule is swallowed and moved by means of natural peristalsis and gravity through the human gastrointestinal (GI) tract. The camera-integrated capsule allows for visualization of the small intestine, a region which was previously inaccessible to classical flexible endoscopy. As a diagnostic tool, it allows to localize the sources of bleedings in the middle part of the gastrointestinal tract and to identify diseases, such as inflammatory bowel disease (Crohn's disease), polyposis syndrome, and tumors. The screening and diagnostic efficacy of the WCE, especially in the stomach region, is hampered by a variety of technical challenges like the lack of active capsular position and orientation control. Therapeutic functionality is absent in most commercial capsules, due to constraints in capsular volume and energy storage. The possibility of using body-exogenous magnetic fields to guide, orient, power, and operate the capsule and its mechanisms has led to increasing research in Magnetically Guided Capsule Endoscopy (MGCE). This work shortly reviews the history and state-of-art in WCE technology. It highlights the magnetic technologies for advancing diagnostic and therapeutic functionalities of WCE. Not restricting itself to the GI tract, the review further investigates the technological developments in magnetically guided microrobots that can navigate through the various air-and fluid-filled lumina and cavities in the body for minimally invasive medicine.

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Section: State Of the Art In Research And Developmentmentioning

confidence: 99%

Magnetically guided capsule endoscopy

et al. 2017

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“…Antimicrobial agents such as metronidazole, amoxicillin, tetracycline, clarithromycin and agents which prevent acid secretion or H+, K+ ATPase pump blockers like omeprazole, lansoprazole which inhibit proton pump can be advocated for the treatment. Additionally, medications like cimetidine, ranitidine, and famotidine which belong to the class of histamine receptor antagonists and bismuth salt which directly interrupt bacterial cell5, [10][11][12][13][14] . A high recurrence percentage (60%) has been observed even the drugs effectively treat the condition.…”

Section: Introductionmentioning

confidence: 99%

Anti-ulcer Activities of Herbal Remedies as Alternative Therapy

Sen¹,

Sen²,

Patel³

et al. 2022

JNR

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Peptic ulcer is a disorder that commonly has an effect on the digestive system. It is a chronic illness which has impact on approximately, 10% of the mankind. The majority of current therapy regimens are based on western medicine. Proton pump inhibitors (PPIs) and histamine-2 (H2) receptor antagonists, which are commonly used to treat peptic ulcers, have been linked to side effects, relapses, and drug interactions. However, several investigations have shown that herbal medications can efficiently heal stomach ulcers in humans and animals using different processes. As a result, this review will focus on common plants with medicinal value which can be utilized to cure or prevent peptic ulcers.

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“…MGDDSs have high loading capacity and many polymers can be used such as gelatin, starch, hydroxypropyl cellulose, hydroxypropyl methylcellulose, polyacrylamine, polymethacrylate, and polyalkylcyanoacrylate. The microparticulate dosage forms are better localized in the gastrointestinal tract and are less likely to cause local irritation compared to the single unit systems [6].…”

Section: Introductionmentioning

confidence: 99%

Management of Type II Diabetes using Metformin- Loaded Microparticulate Gastroretentive Delivery Systems

Salatin¹

2020

AJBSR

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Metformin is an oral anti-hyperglycemic derivative extensively used for the treatment of type II diabetes. Following oral administration, metformin exhibits an incomplete absorption and therefore repeated administrations of high doses of this drug are required for successful therapy due to its short biological half-life. For this, development of novel drug delivery systems for metformin might be useful to decrease the dosing frequency, to enhance its bioavailability, to reduce gastrointestinal adverse effects, and to be helpful for effective use of metformin in diabetes treatment. In this review, we present microparticulate gastroretentive delivery systems developed to enhance the oral bioavailability of metformin.

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Novel Drug Delivery Systems for Modulation of Gastrointestinal Transit Time

Cited by 7 publications

References 51 publications

Magnetically guided capsule endoscopy

Magnetically guided capsule endoscopy

Anti-ulcer Activities of Herbal Remedies as Alternative Therapy

Management of Type II Diabetes using Metformin- Loaded Microparticulate Gastroretentive Delivery Systems

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