Novel dual‐sensitization electrochemiluminescence immunosensor using photopermeable Ru(bpy)₃²⁺‐doped chitosan/SiO₂ nanoparticles as labels and chitosan‐decorated Nafion/MWNTs composites as enhancer

Abstract

A novel dual-sensitization electrochemiluminescence (ECL) immunosensor for the detection of tumour protein prostate specific antigen (PSA) at trace level using Ru(bpy) 3 2+ -doped chitosan/SiO 2 nanoparticles (Ru(bpy) 3 2+ /chitosan/SiO 2 NPs) as

Fluorescence immunosensor based on functional nanomaterials and its application in tumor biomarker detection

“…29,30 In recent years, nanomaterials have developed rapidly and have been successfully used as carriers of ECL light emitters, which effectively improve the properties of ECL. For example, Chang et al, 31 designed a novel dual-sensitization ECL immunosensor. In this method, Ru(bpy) 3 2+ -doped chitosan/SiO 2 nanoparticles were used as the rst signal enhancers, and chitosan modied peruoro sulfonic acid/multiwall carbon nanotubes (Naon/ MWNTs) composites were used as the second sensitizing matrix to seize large amounts of prostate specic capture antibody, which signicantly enhanced the ECL reaction efficiency produced by Ru(bpy) 3 2+ .…”