Novel Eudragit® -based polymeric nanoparticles for sustained release of simvastatin

Abstract

This paper reports on the development of nanoparticles aiming at the in vitro controlled release of simvastatin (SVT). The nanoparticles were prepared by the nanoprecipitation method with polymers Eudragit ® FS30D (EDGFS) or Eudragit ® NE30D (EDGNE). EDGFS+SVT nanoparticles showed mean size of 148.8 nm and entrapment efficiency of 76.4%, whereas EDGNE+SVT nanoparticles showed mean size of 105.0 nm and entrapment efficiency of 103.2%. Infrared absorption spectra demonstrated that SVT incorporated into the polymer matrix, especially EDGNE. Similarly, the differential scanning calorimeter (DSC) curve presented no endothermic peak of fusion, indicating that the system is amorphous and the drug is not in the crystalline state. The maintenance of SVT in the amorphous state may favors its solubilization in the target release sites. In the in vitro dissolution assay, the SVT incorporated into the EDGFS+SVT nanoparticles showed a rapid initial release, which may be related to the pH of the dissolution medium used. Regarding the EDGNE+SVT nanoparticles, the in vitro release occurred in a bimodal behavior, i.e., an initial "burst" followed by a sustained delivery, with the kinetics of drug release following Baker-Lonsdale's mathematical model. All these features suggest the nanoparticulate system's potential to modulate SVT delivery and enhance its bioavailability.

Polymer based dual drug delivery system for targeted treatment of fluoroquinolone resistant Staphylococcus aureus mediated infections

“…However, a further increase in the polymer concentration (1:2 ratio) displayed no significant difference in the entrapment of the drug. The results were comparable to the previously published reports of Eudragit polymeric nanoparticles, wherein an equal ratio of drug and polymer showed maximum entrapment efficiency 42 , 43 . Hence, the nanoparticles developed with a 1:1 ratio with maximum drug entrapment of 90% were selected as the optimized ones for further characterization and application.…”

Polymer-based dual drug delivery system for targeted treatment of fluoroquinolone-resistant Staphylococcus aureus mediated infections

“…However, a further increase in the polymer concentration (1:2 ratio) had displayed no signi cant difference in the entrapment of the drug. The results were comparable to the previously published reports of Eudragit polymeric nanoparticles, wherein equal ratio of drug and polymer showed maximum entrapment e ciency 43,44 . Hence, the nanoparticles developed with a 1:1 ratio with maximum drug entrapment of 90% were selected as the optimized ones for further characterization and application.…”

Polymeric versus lipid nanocapsules for miconazole nitrate enhanced topical delivery: in vitro and ex vivo evaluation

“…The results portrayed that free MN, F1, and F6 release have followed zero order, Higuchi diffusion and Baker and Lonsdale models, respectively, based on regression coefficient values ( Table 3 ). Pure MN displayed a continuous release of the same amount of drug per unit time (zero order) which correlated to its lipophilicity that is characterized by release kinetics of this nature (Rodrigues et al., 2020 ). In turn, PNCs (F1) are best fitted to Higuchi’s diffusion model where the drug released from the nanocapsules after the degradation of thin polymeric outer shell membrane is governed by the slow diffusion of MN from the viscous PCL matrix rather than erosion mechanism (El-Hesaisy & Swidan, 2020 ).…”