Novel flavonoids with antioxidant activity from a Chenopodiaceous plant

Awaad, Amani S.; Maitland, Derek J.; Donia, Abd El Raheim M.; Alqasoumi, Saleh I.; Soliman, Gamal A.

doi:10.3109/13880209.2011.591806

Cited by 37 publications

(25 citation statements)

References 10 publications

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“…Data in table (1) revealed that methanolic extract and PAPs contained average total polyphenols values of 89.7 and11.16 mgGAE/g dry weight, respectively. PAPs yielded lower total phenols content than MeOH extract.…”

Section: Results and Discussion:-mentioning

confidence: 99%

“…It was found as 74.7 and 3.18 mg QE/g for MeOH extract and PAPs, respectively ( Table 1). The number of hydroxyl groups and substitution with electron-donating alkyl or methoxy groups of flavonoids cause an increase in their antioxidant activity (Awaad et al, 2012 HPLC separation of flavonoids and phenolic compounds:-High-performance liquid chromatograph equipped with a diode array detector was used to determine the flavonoids and phenolic compounds in the methanol extract of Plumeria alba leaves. Table 2 shows the amount of nine phenolic compounds, including, pyrogallol, rosmaric, ferrulic acid, vanillic acid, p.coumaric acid, ellaglic acid, salycillic acid, cinamic acid and protocatechuic and ten flavonoids, including catechin, Epicatechin, rutin, hisperedin, narenigin, quercetin, hesperetin, apigenin, kaempferol and Diosmitin in 100 g dry matter of MeOH extract of Plumeria alba leaves.…”

Section: Results and Discussion:-mentioning

confidence: 99%

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Antioxidant Activity Evaluation of Methanolic Extract and Crude Polysaccharides From Plumeria Alba L. Leaves.

Dawood¹,

Hassan²,

AbdelFattah³

2016

IJAR

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Section: Results and Discussion:-mentioning

confidence: 99%

Section: Results and Discussion:-mentioning

confidence: 99%

Antioxidant Activity Evaluation of Methanolic Extract and Crude Polysaccharides From Plumeria Alba L. Leaves.

Dawood¹,

Hassan²,

AbdelFattah³

2016

IJAR

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“…Nevertheless, literature review connects the bioactivity to many compounds. Flavonoids have been associated to various biological activities amongst which antiviral and antioxidant effects [53]. Kulisic-Bilusic et al [54] reported antioxidant activities for procyanidins and anthocyanins.…”

Section: Effect Of the Extraction Parameters On Thementioning

confidence: 99%

Extraction of Total Phenolic Compounds, Flavonoids, Anthocyanins and Tannins from Grape Byproducts by Response Surface Methodology. Influence of Solid-Liquid Ratio, Particle Size, Time, Temperature and Solvent Mixtures on the Optimization Process

Rajha¹,

Darra²,

Hobaika³

et al. 2014

FNS

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The current work concerns the optimization process of phenolic compounds solid liquid extraction from grape byproducts at high temperatures and short incubation times. The effect of five experimental parameters (solidliquid ratio, particle size, time, temperature and solvent mixture) mostly believed to affect the extraction process was undertaken. A first response surface methodology experimental design was used to optimize the solid-liquid ratio and milling time parameters. A second design was used for the optimization of the quantitative and qualitative parameters. The quantitative parameters studied are: total phenolic compounds, flavonoid content, total monomeric anthocyanin composition and tannin concentration. The qualitative parameters analyzed are: antiradical activity and antioxidant capacity. The second design was based on the use of time, temperature and solvent mixture as optimization parameters. The assays were first conducted separately revealing the best experimental conditions for the maximization of each response variable alone. A simultaneous response surface methodology of all the responses taken together was then conducted, showing the optimal extraction conditions to be: 93 minutes at 94˚C and in 66% ethanol/water solvent. The maximal response values obtained for each parameter are: Total Phenolic Compounds yield (5.5 g GAE/100g DM), Flavonoid Content (5.4 g GAE/100g DM), Total Monomeric Anthocyanin yield (70.3 mg/100g DM), Tannin Concentration (12.3 g/L), Antiradical Activity (67.3%) and Total Antioxidant Capacity (393 mgAAE/L). All of the optimal values were acquired at 3 mL/g solid-liquid ratio and 6.8 min milling time. The obtained extracts could be used as natural bioactive compounds in several industrial applications.

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“…The results indicated that the hepatoprotection by the flavonoid-enriched fraction was due to its antioxidant properties through enhancing the activity of SOD, GPx, and CAT ( Figure 4). As a type of phenolic compound, flavonoids have attracted increasing attention particularly for their attractive antioxidant activities (Awaad et al, 2012;Prommuak et al, 2008). DOI: 10.3109/13880209.2015.1010737 They have also been reported to offer a promising source of potential antioxidants (Wang et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Protective effects ofHammada scopariaflavonoid-enriched fraction on liver injury induced by warm ischemia/reperfusion

Saidi

Bourogâa

Bouaziz

et al. 2015

Pharmaceutical Biology

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Context: Hepatic ischemia/reperfusion injury (IRI) is a major cause of liver damage during liver surgery and transplantation. Plants have historically been used in treating liver damage, and Hammada scoparia (Pomel) (Chenopodiaceae) has been reported to possess a broad spectrum of pharmacological and therapeutic activities. Objective: In this study, a flavonoid-enriched fraction was used before the warm ischemia (WI) process as pharmacological preconditioning and in combination with technical postconditioning to evaluate their protective effects. Materials and methods: The rats were divided into five groups: a sham group; a control group (Control-IR) that was submitted to 60 min WI; a Pharmacological Preconditioning group (PreC-IR) that received flavonoid-enriched fraction (200 mg/kg body weight); a Postconditioning group (PostC) and a PreC + PostC group. Results: The use of the flavonoid-enriched fraction was noted to significantly (p50.05) reduce liver injury, as evidenced by the decrease in liver transaminase activities (AST and ALT) and lactic dehydrogenase (LDH), alkaline phosphatase (ALP), and lipid peroxidation (TBARS), levels as well as the enhancement of antioxidant enzymes (catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx)) responses. The results also indicated that, compared with the separate application of pharmacological preconditioning and postconditioning, the combination of both treatments was more effective in reducing tissue oxidative stress levels through modulating SOD, GSH-PX, and CAT activities. Furthermore, the combined protocol further decreased the liver morphological score compared with solo treatment. Discussion and conclusion: Overall, the results indicate that the H. scoparia flavonoid-enriched fraction could be a promising candidate for future application as a pharmacological preconditioning agent against hepatic IRI.

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Novel flavonoids with antioxidant activity from a Chenopodiaceous plant

Cited by 37 publications

References 10 publications

Antioxidant Activity Evaluation of Methanolic Extract and Crude Polysaccharides From Plumeria Alba L. Leaves.

Antioxidant Activity Evaluation of Methanolic Extract and Crude Polysaccharides From Plumeria Alba L. Leaves.

Extraction of Total Phenolic Compounds, Flavonoids, Anthocyanins and Tannins from Grape Byproducts by Response Surface Methodology. Influence of Solid-Liquid Ratio, Particle Size, Time, Temperature and Solvent Mixtures on the Optimization Process

Protective effects ofHammada scopariaflavonoid-enriched fraction on liver injury induced by warm ischemia/reperfusion

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