Novel fluorescence palladium-alkoxime complexes: Synthesis, characterization, DNA/BSA spectroscopic and docking studies, evaluation of cytotoxicity and DNA cleavage mechanism

Karami, Kazem; Jamshidian, Nasrin; Bagheri, Atefe; Hajiaghasi, Afsaneh; Momtazi‐Borojeni, Amir Abbas; Abdollahi, Elham; Shahpiri, Azar; Azizi, Negar; Lipkowski, Janusz

doi:10.1016/j.molstruc.2019.127595

Cited by 18 publications

(1 citation statement)

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“…Viscosity measurement is key method to distinguish the binding mode of small molecules and DNA, including intercalation or non‐intercalation [40] . Intercalation binding significantly increases the length and viscosity of DNA, while grooved binding agents have no or little effect on DNA viscosity [41] .…”

Section: Resultsmentioning

confidence: 99%

Exploring the Potential Mechanism of Costunolide‐Induced MCF‐7 Cells Apoptosis by Multi‐Spectroscopy, Molecular Docking and Cell Experiments

Liú

Zeng

et al. 2021

Chemistry & Biodiversity

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Breast cancer is one of the most common cancer with high morbidity and mortality in women. This study aimed to explore the potential mechanism of costunolide inducing MCF‐7 cells apoptosis by multi‐spectroscopy, molecular docking, and cell experiments. The results manifested that costunolide interacted with calf thymus DNA (ct‐DNA) in a spontaneous manner, and the minor groove as the preferential binding mode. Furthermore, costunolide inhibited cell proliferation and colony formation. Hoechst 33258 staining showed that cell apoptosis induced by costunolide might be related to DNA damage. The apoptosis mechanism relied on regulating the protein expression of Bax, Bcl‐2, p53, Caspase‐3 and the activation of p38MAPK and nuclear factor κB (NF‐κB) pathways. This study will provide some experimental basis and potential therapeutic strategy for breast cancer treatment.

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Section: Resultsmentioning

confidence: 99%