Novel genetic polymorphisms associated with carcass traits in grazing Texel sheep

Recent advances in understanding genetic variants associated with growth, carcass and meat productivity traits in sheep (<i>Ovis aries</i>): an update

“…Gene NCAPG encodes protein CAP-G, which is a subunit of condensin I, a large protein complex involved in chromosome condensation. It was associated with body weight, postweaning gain, bone-related traits and multivariate phenotype (Al-Mamun et al, 2015;Bolormaa et al, 2016).…”

“…Gene ACACA encodes protein that catalyses the ratelimiting reaction in the biogenesis of long-chain fatty acids. This candidate gene was reported to be associated with muscle depth, fatty acid formation and several multivariate phenotypes related to carcass (Bolormaa et al, 2016;Garza Hernandez et al, 2018).…”

“…Gene LCORL encodes a transcription factor that appears to function in spermatogenesis. It was associated with body weight, post-weaning gain, bone-related traits and several carcass multivariate phenotypes (Al-Mamun et al, 2015;Bolormaa et al, 2016). Such a low number of genes overlapping between different studies can be attributed to the tendency towards reporting only the nearest-to-SNP gene.…”

“…Gene prioritization refers to a family of computational techniques for inferring which gene from a studied region (if there are more than one) is really associated with trait of interest. Only two papers have performed the specific gene prioritization techniques (Bolormaa et al, 2016;Kominakis et al, 2017). Larger sample sizes and more advanced approaches for gene prioritization are necessary to improve the concordance between the reported genes.…”

“…S3) that led to the final list of 18 publications. Nine of them described GWAS analysis (Riggio et al, 2013;Zhang et al, 2013;Al-Mamun et al, 2015;Bolormaa et al, 2016;Matika et al, 2016;Kominakis et al, 2017;Garza Hernandez et al, 2018;Pasandideh et al, 2018;Ghasemi et al, 2019), seven described gene candidate analysis (Jalil-Sarghale et al, 2014;Cinar et al, 2016;Trukhachev et al, 2016;Zhang et al, 2016;Aali et al, 2017;Armstrong et al, 2018) and two were reviews (Sahu et al, 2017;Xu and Li, 2017) (Table ST3).…”