Novel hantavirus identified in black-bearded tomb bats, China

Xu, Lin; Wu, Jianmin; He, Bingfang; Qin, Shaomin; Xia, Lele; Qin, Minchao; Li, Nan; Tu, Changchun

doi:10.1016/j.meegid.2015.01.018

Cited by 27 publications

(34 citation statements)

References 13 publications

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“…Hantaviruses (genus Hantavirus, family Bunyaviridae) are responsible for life-threatening human diseases: hantavirus cardiopulmonary syndrome (HCPS) in the Americas and hemorrhagic fever with renal syndrome (HFRS) in Asia and Europe (Krüger et al, 2011). Rodents are natural reservoirs of hantaviruses; however, recent studies have demonstrated that insectivores and bats also represent hosts for divergent hantaviruses (Xu et al, 2015;Zhang, 2014;Witkowski et al, 2016). Bats are considered the natural reservoir of a large variety of zoonotic viruses causing serious human diseases, such as lyssaviruses, henipaviruses, severe acute respiratory syndrome coronavirus, and Ebola virus (Li et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

“…Bats are considered the natural reservoir of a large variety of zoonotic viruses causing serious human diseases, such as lyssaviruses, henipaviruses, severe acute respiratory syndrome coronavirus, and Ebola virus (Li et al, 2010). Genetically divergent bat-borne hantaviruses have been identified in Africa -Mouyassue virus (MOYV) in Cote d'Ivoire (Sumibcay et al, 2012), Magboi virus (MGBV) in Sierra Leone (Weiss et al, 2012), and Makokou virus (MAKV) in Gabon (Witkowski et al, 2016) and in Asia -Xuan Son virus (XSV) in Vietnam (Arai et al, 2013), Huangpi virus (HUPV), Longquan virus (LQUV), Laibin virus (LBV) in China (Xu et al, 2015;Guo et al, 2013), and Quezon virus (QZNV) in the Philippines (Arai et al, 2016). Here we report the detection of a novel hantavirus, tentatively named Brno virus (BRNV), in the European insectivorous bat species Nyctalus noctula collected in the Czech Republic, Central Europe.…”

Section: Introductionmentioning

confidence: 99%

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Novel hantavirus identified in European bat species Nyctalus noctula

Straková

Dufková

Širmarová

et al. 2017

Infection, Genetics and Evolution

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Novel hantavirus identified in European bat species Nyctalus noctula

Straková

Dufková

Širmarová

et al. 2017

Infection, Genetics and Evolution

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“…Since the outbreak of SARS in 2003, interest in bat‐borne viruses has been increasing and novel viruses are continually found in bats all around the world. A number of studies reported that bats, especially from southern China, carried a variety of viruses (Chu, Poon, Guan, & Peiris, ; Ge et al., , , ; Hu et al., ; Li et al., ; Wu et al., ; Xu et al., ; Yang et al., ; Yuan et al., ). However, so far, few studies have been conducted on bats in northern China, which harbours a diversity of endemic insectivorous bats.…”

Section: Introductionmentioning

confidence: 99%

Novel coronaviruses, astroviruses, adenoviruses and circoviruses in insectivorous bats from northern China

Han

Wen

Zhao

et al. 2017

Zoonoses and Public Health

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Bats are considered as the reservoirs of several emerging infectious disease, and novel viruses are continually found in bats all around the world. Studies conducted in southern China found that bats carried a variety of viruses. However, few studies have been conducted on bats in northern China, which harbours a diversity of endemic insectivorous bats. It is important to understand the prevalence and diversity of viruses circulating in bats in northern China. In this study, a total of 145 insectivorous bats representing six species were collected from northern China and screened with degenerate primers for viruses belonging to six families, including coronaviruses, astroviruses, hantaviruses, paramyxoviruses, adenoviruses and circoviruses. Our study found that four of the viruses screened for were positive and the overall detection rates for astroviruses, coronaviruses, adenoviruses and circoviruses in bats were 21.4%, 15.9%, 20% and 37.2%, respectively. In addition, we found that bats in northern China harboured a diversity of novel viruses. Common Serotine (Eptesicus serotinu), Fringed long-footed Myotis (Myotis fimriatus) and Peking Myotis (Myotis pequinius) were investigated in China for the first time. Our study provided new information on the ecology and phylogeny of bat-borne viruses.

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“…HFRS is a typical rodent-borne disease and a severe public health issue in China [5]. In addition to rodents, hantaviruses have recently been detected in shrews (order Soricomorpha, family Soricidae and Talpidae) [6][7][8][9][10][11] and bats (order Chiroptera, family Rhinolophidae, Hipposideridae, Vespertilionidae, and Nycteridae) [12][13][14][15][16], but it is not clear whether these hantaviruses lead to human illness. It is believed that only hantaviruses in rodent hosts (order Rodentia, family or subfamily Muridae, Arvicolinae, and Sigmodontinae) cause HFRS and HPS in Asia, Europe, Africa, and North America [17].…”

Section: Introductionmentioning

confidence: 99%

Fugong virus, a novel hantavirus harbored by the small oriental vole (Eothenomys eleusis) in China

Yang

Pan

et al. 2016

Virol J

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BackgroundRodents are natural reservoirs of hantaviruses, which cause two disease types: hemorrhagic fever with renal syndrome in Eurasia and hantavirus pulmonary syndrome in North America. Hantaviruses related human cases have been observed throughout Asia, Europe, Africa, and North America. To date, 23 distinct species of hantaviruses, hosted by reservoir, have been identified. However, the diversity and number of hantaviruses are likely underestimated in China, and hantavirus species that cause disease in many regions, including Yunnan province, are unknown.ResultsIn August 2012, we collected tissue samples from 189 captured animals, including 15 species belonging to 10 genera, 5 families, and 4 orders in Fugong county, Yunnan province, China. Seven species were positive for hantavirus: Eothenomys eleusis (42/94), Apodemus peninsulae (3/25), Niviventer eha (3/27), Cryptotis montivaga (2/8), Anourosorex squamipes (1/1), Sorex araneus (1/1), and Mustela sibirica (1/2). We characterized one full-length genomic sequence of the virus (named fugong virus, FUGV) from a small oriental vole (Eothenomys eleusis). The full-length sequences of the small, medium, and large segments of FUGV were 1813, 3630, and 6531 nt, respectively. FUGV was most closely related to hantavirus LX309, a previously reported species detected in the red-backed vole in Luxi county, Yunnan province, China. However, the amino acid sequences of nucleocapsid (N), glycoprotein (G), and large protein (L) were highly divergent from those of Hantavirus LX309, with amino acid differences of 11.2, 15.3, and 12.7 %, respectively. In phylogenetic trees, FUGV clustered in the lineage corresponding to hantaviruses carried by rodents in the subfamily Arvicolinae.ConclusionsHigh prevalence of hantavirus infection in small mammals was found in Fugong county, Yunnan province, China. A novel hantavirus species FUGV was identified from the small oriental vole. This virus is phylogenetic clustering with another hantavirus LX309, but shows highly genomic divergence.

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Novel hantavirus identified in black-bearded tomb bats, China

Cited by 27 publications

References 13 publications

Novel hantavirus identified in European bat species Nyctalus noctula

Novel hantavirus identified in European bat species Nyctalus noctula

Novel coronaviruses, astroviruses, adenoviruses and circoviruses in insectivorous bats from northern China

Fugong virus, a novel hantavirus harbored by the small oriental vole (Eothenomys eleusis) in China

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