Novel Hydroquinone as a Matrix Metallo-proteinase Inhibitor from the Mushroom,<i>Piptoporus betulinus</i>

Kawagishi, Hirokazu; Hamajima, Keiko; Inoue, Yoshimasa

doi:10.1271/bbb.66.2748

Cited by 18 publications

(5 citation statements)

References 5 publications

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“…It was shown that polyporenic acid C, just like another compound isolated from F. betulina , i.e. (E)-2-(4-hydroxy-3methyl-2-butenyl)-hydroquinone, had inhibitory activity against some matrix metalloproteinases (MMP), with IC 50 values (concentration causing inhibition by 50% compared to control) in the range from 23 to 128 µM (Kawagishi et al 2002). Polyporenic acid C and three other F. betulina triterpenoids (Table 1) showed anti-inflammatory and antibacterial activity by strong inhibition of 3α-hydroxysteroid dehydrogenase and bacterial hyaluronate lyase activity, respectively (Wangun et al 2004).…”

Section: Biotechnological Usesmentioning

confidence: 99%

Fomitopsis betulina (formerly Piptoporus betulinus): the Iceman’s polypore fungus with modern biotechnological potential

Pleszczyńska

Lemieszek

Siwulski

et al. 2017

World J Microbiol Biotechnol

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Higher Basidiomycota have been used in natural medicine throughout the world for centuries. One of such fungi is Fomitopsis betulina (formerly Piptoporus betulinus), which causes brown rot of birch wood. Annual white to brownish fruiting bodies of the species can be found on trees in the northern hemisphere but F. betulina can also be cultured as a mycelium and fruiting body. The fungus has a long tradition of being applied in folk medicine as an antimicrobial, anticancer, and anti-inflammatory agent. Probably due to the curative properties, pieces of its fruiting body were carried by Ötzi the Iceman. Modern research confirms the health-promoting benefits of F. betulina. Pharmacological studies have provided evidence supporting the antibacterial, anti-parasitic, antiviral, anti-inflammatory, anticancer, neuroprotective, and immunomodulating activities of F. betulina preparations. Biologically active compounds such as triterpenoids have been isolated. The mushroom is also a reservoir of valuable enzymes and other substances such as cell wall (1→3)-α-d-glucan which can be used for induction of microbial enzymes degrading cariogenic dental biofilm. In conclusion, F. betulina can be considered as a promising source for the development of new products for healthcare and other biotechnological uses.

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Section: Biotechnological Usesmentioning

confidence: 99%

Fomitopsis betulina (formerly Piptoporus betulinus): the Iceman’s polypore fungus with modern biotechnological potential

Pleszczyńska

Lemieszek

Siwulski

et al. 2017

World J Microbiol Biotechnol

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“…The wood-rotting fungus Fomitopsis betulinus is widely distributed across mainland China. This fungus produces triterpene acids and hydroquinones with anti-inflammatory, antihyaluronate lyase, and matrix metallo-proteinase inhibitory activity. − In the present study, the fungus Xylaria longipes was isolated from the fruiting bodies of F. betulinus . The metabolites of cultures of X. longipes have been chemically investigated, which led to the isolation of 18 nor-isopimaranes.…”

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confidence: 87%

Immunosuppressive Nor-isopimarane Diterpenes from Cultures of the Fungicolous Fungus Xylaria longipes HFG1018

et al. 2020

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Eighteen new nor-isopimarane diterpenes, xylarinorditerpenes A−R (1−18), along with two previously reported compounds, 14α,16-epoxy-18-norisopimar-7-en-4α-ol (19) and the labdane-type diterpene agatadiol (20), were isolated from cultures of the fungicolous fungus Xylaria longipes HFG1018 isolated from the wood-rotting basidiomycete Fomitopsis betulinus. The structure elucidation and relative configuration assignments of 1−18 were accomplished by interpretation of spectroscopic data and through computational methods. The absolute configurations of 1, 4, and 16 were determined by single-crystal X-ray diffraction. Compounds 1− 16 possess an 18-or 19-nor-isopimarane skeleton, and compounds 17 and 18 possess an 18,19-dinor-isopimarane skeleton. Compounds 2−5, 9, 14, 19, and 20 showed immunosuppressive activity but were devoid of cytotoxicity against the cell proliferation by concanavalin A-induced T lymphocytes and lipopolysaccharide-induced B lymphocytes, with IC 50 values varying from 1.0 to 27.2 μM and from 16.1 to 51.8 μM, respectively.

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“…Compound 24 was also isolated from Daedalea dickinsii. MMPs mediate physiological extracellular matrix remodelling and have been implicated in several pathological processes including tumor growth and metastasis [37].…”

Section: Low Molecular Weight Compounds With Antitumor Potentialmentioning

confidence: 99%

Compounds from Wild Mushrooms with Antitumor Potential

Ferreira¹,

Vaz²,

Vasconcelos³

et al. 2010

ACAMC

254

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For thousands of years medicine and natural products have been closely linked through the use of traditional medicines and natural poisons. Mushrooms have an established history of use in traditional oriental medicine, where most medicinal mushroom preparations are regarded as a tonic, that is, they have beneficial health effects without known negative side-effects and can be moderately used on a regular basis without harm. Mushrooms comprise a vast and yet largely untapped source of powerful new pharmaceutical products. In particular, and most importantly for modern medicine, they represent an unlimited source of compounds which are modulators of tumour cell growth. Furthermore, they may have potential as functional foods and sources of novel molecules. We will review the compounds with antitumor potential identified so far in mushrooms, including low-molecular-weight (LMW, e.g.

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Novel Hydroquinone as a Matrix Metallo-proteinase Inhibitor from the Mushroom,Piptoporus betulinus

Cited by 18 publications

References 5 publications

Fomitopsis betulina (formerly Piptoporus betulinus): the Iceman’s polypore fungus with modern biotechnological potential

Fomitopsis betulina (formerly Piptoporus betulinus): the Iceman’s polypore fungus with modern biotechnological potential

Immunosuppressive Nor-isopimarane Diterpenes from Cultures of the Fungicolous Fungus Xylaria longipes HFG1018

Compounds from Wild Mushrooms with Antitumor Potential

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