Novel ibuprofenate- and docusate-based ionic liquids: emergence of antimicrobial activity

Abstract

Six new ionic-liquid-based active pharmaceutical ingredients (IL-APIs) were prepared and their molecular structures characterized.

The effect of alcohols as vehicles on the percutaneous absorption and skin retention of ibuprofen modified with l-valine alkyl esters

“…In the literature, inorganic salts, such as sodium, 28 potassium, calcium, magnesium, aluminum, 29 copper, 30 zincum, 31 and organice.g. lizynium, 32 ranitidinium, diphenhydraminium, 33 benzalkonium, didecyldimethylammonium 34 salts. The ibuprofen alkylamine salts were obtained by Sarveiya et al Those salts were characterized by the higher diffusion through the PDMS (polydimethylsiloxane) membrane compared to the sodium salt.…”

Preparation of ibuprofen‐loaded HDPE tubular devices for application as urinary catheters

“…After 24 h, more than 5% of the IBP had been released from all samples, which is the concentration employed in topical formulations to achieve effective anti‐inflammatory activity . The concentration after 7 days (6 mg/mL) is known to exhibit antimicrobial activity against strains, which are clinically relevant to the urinary environment …”

“…Ibuprofen (IBP) is a traditional nonsteroidal anti‐inflammatory agent . Recent studies have shown that this compound and its co‐formulations have an antimicrobial effect against bacteria and fungi relevant to the urinary tract, such as S. aureus and Candida albicans . Furthermore, IBP has high thermal stability, facilitating the catheter manufacture through the melt extrusion process, which has been widely employed in the production of polymeric drug delivery systems .…”

Ketoprofen-Based Ionic Liquids: Synthesis and Interactions with Bovine Serum Albumin

“…Further, the development of ILs based on active pharmaceutical ingredients (API-ILs), single active liquid salts, is a possible solution of some of the problems of solid and/or hydrophobic drugs such as low solubility and bioavailability, polymorphism and an alternative route of administration could be suggested as compared to the classical drug [11,12]. In addition, ILs based on two biologically active ions have been also investigated, e.g., ILs containing a cation with anti-bacterial or pain-reliever properties and an anion anti-inflammatory, antibacterial, anti-pyretic activity, or wetting agents and emollients [13,14]. They have the advantage to retain the biological activities inherited from the two API-precursors [11,15].…”

“…An enhanced topical anti-inflammatory activity was reported for a series of ILs containing cations terpenes and anion Ibu [17]. Interestingly, Ibu-based ILs containing cations ranitidinium or diphenhydraminium exhibited activity against Candida sp., which was not inherited from the parent salt-however, they are shown to be more cytotoxic to human lymphocytes [14]. Based on IL 50 values estimated for the inhibition of cytochrome C oxidase, Azevedo et al have found that the cholinium ketoprofenate (IC 50 ≈ 21.3 mM) produced a lower cytotoxic effect than sodium ketoprofenate (IC 50 ≈ 0.0006 mM) and therefore it is considered safer [18].…”