Novel Immunological Aspects for the Treatment of Age‐induced Ovarian and Testicular Infertility, Other Functional Diseases, and Early and Advanced Cancer Immunotherapy

Bukovský, Antonín

doi:10.1002/9781118849613.ch4

Cited by 3 publications

(4 citation statements)

References 108 publications

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“…Also shown is a dividing unstained CSC exhibiting denser cytoplasm in one of its developing daughters (red arrow). The inset in Figure5Ashows dividing CSC containing STC in one of the emerging daughters, resembling the situation during ASCD in the adult human ovary[45]. The cancer DCD containing STC contribute to the unlimited grow of cancer cell bulk and the cancer SCD will divide asymmetrically again after interaction with another host STC (see the yellow arrowhead in the Figure5A).…”

mentioning

confidence: 84%

Former Effective Immunotherapy without Adverse Events of Inoperable Epithelial Ovarian Cancers and a Prospect for the Immune Prophylaxis

Bukovský¹,

Mr²

2018

Journal of Gynecology Research

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Background: Current cancer treatments by immune checkpoint blockades are limited due to severe adverse events caused by alteration of the immune system required for homeostasis of normal tissues. Common cancer chemotherapy alters the quality of patients' lives. Platinum-based treatment can lead to severe neurotoxicity with chronic debilitation. Additionally, survival of patients with epithelial ovarian cancers (EOCs) has remained poor despite extensive cytoreductive surgery, high dose chemotherapy, checkpoint blockades and immunotherapies effective in some other types of cancer. The pathobiology of EOC cancer stem cells (CSCs) is not well understood. Observations demonstrate that EOCs exhibit in vivo two distinct CSC types -perivascular diploid CSCs dividing asymmetrically with the help of the host suicidal CD8+ T cells, and haploid CSCs at the cancer abdominal surface originating from meiosis I cytokinesis of bulk surface cancer cells. The perivascular CSCs contribute to the cancer cell bulk and, via left ovary venous blood, can cause EOC liver metastases. Haploid CSCs released from the bulk cancer surface cause the common pelvic and abdominal EOC spread. Former elimination of the host antibodies blocking T cell effectors by intermittent doses of cyclophosphamide exhibiting significant immunomodulatory anticancer effects, facilitation of the immune system reactivity against alloantigens of cancer cells by blood transfusions, and augmentation of anticancer immunity by bacterial toxins, resulted during the subsequent treatment-free period into rejection of inoperable EOCs without any adverse events during the treatnment. To help prevent cancer relapses, patients treated for advanced primary epithelial cancers should be considered as candidates for continuously stimulating immune anticancer activity by treatments such as daily metformin and weekly lentinan consumptions.

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mentioning

confidence: 84%

Former Effective Immunotherapy without Adverse Events of Inoperable Epithelial Ovarian Cancers and a Prospect for the Immune Prophylaxis

Bukovský¹,

Mr²

2018

Journal of Gynecology Research

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“…Arrowheads indicate a diminution of dental fissure (compare with panel I). Numbers indicate the image collection dates[161]. …”

Section: Can the Aging Be Delayed?mentioning

confidence: 99%

“…Advanced malignant stages are not excluded, assuming there is a normal value of the circulating mononuclear cells being capable to be involved. The treatment may involve malignancies regardless of their extent, but lower effectiveness can be anticipated in cancers affecting mononuclear blood cells, and limitations might occur in the brain malignancies[161]. In the cases with an early malignancy and for prevention of cancer recurrence the weekly consumption of the raw Shiitake mushroom can be effective.…”

Section: Why the Cancer Cells Survive And How To Reject Them?mentioning

confidence: 99%

“…The development of dermatitis after the raw shiitake mushroom consumption may indicate the stimulation of the IMS reactivity, eventually accompanied by the good anticancer response. Continuing weekly utilization of the raw shiitake mushroom in salads caused no skin rashes or pruritus and prevented any appearance of the colorectal or other symptoms of malignancy for twenty-five years thereafter[161]. …”

Section: Why the Cancer Cells Survive And How To Reject Them?mentioning

confidence: 99%

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Involvement of blood mononuclear cells in the infertility, age-associated diseases and cancer treatment

Bukovský

2016

WJSC

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Blood mononuclear cells consist of T cells and monocyte derived cells. Beside immunity, the blood mononuclear cells belong to the complex tissue control system (TCS), where they exhibit morphostatic function by stimulating proliferation of tissue stem cells followed by cellular differentiation, that is stopped after attaining the proper functional stage, which differs among various tissue types. Therefore, the term immune and morphostatic system (IMS) should be implied. The TCS-mediated morphostasis also consists of vascular pericytes controlled by autonomic innervation, which is regulating the quantity of distinct tissues in vivo. Lack of proper differentiation of tissue cells by TCS causes either tissue underdevelopment, e.g., muscular dystrophy, or degenerative functional failures, e.g., type 1 diabetes and age-associated diseases. With the gradual IMS regression after 35 years of age the gonadal infertility develops, followed by a growing incidence of age-associated diseases and cancers. Without restoring an altered TCS function in a degenerative disease, the implantation of tissue-specific stem cells alone by regenerative medicine can not be successful. Transfused young blood could temporarily restore fertility to enable parenthood. The young blood could also temporarily alleviate aging diseases, and this can be extended by substances inducing IMS regeneration, like the honey bee propolis. The local and/or systemic use of honey bee propolis stopped hair and teeth loss, regressed varicose veins, improved altered hearing, and lowered high blood pressure and sugar levels. Complete regression of stage IV ovarian cancer with liver metastases after a simple elaborated immunotherapy is also reported.

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The Impact of Immune Status Characteristics on the Results of in Vitro Fertilization in Patients With Infertility

Ismayilova

2023

WOMAB

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Novel Immunological Aspects for the Treatment of Age‐induced Ovarian and Testicular Infertility, Other Functional Diseases, and Early and Advanced Cancer Immunotherapy

Cited by 3 publications

References 108 publications

Former Effective Immunotherapy without Adverse Events of Inoperable Epithelial Ovarian Cancers and a Prospect for the Immune Prophylaxis

Former Effective Immunotherapy without Adverse Events of Inoperable Epithelial Ovarian Cancers and a Prospect for the Immune Prophylaxis

Involvement of blood mononuclear cells in the infertility, age-associated diseases and cancer treatment

The Impact of Immune Status Characteristics on the Results of in Vitro Fertilization in Patients With Infertility

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