Novel In Vitro Intestinal Microbiome Model to Study Lipidomic and Metabolomic Adaptations Due to Exposure to Glyphosate, Perfluorooctanoic Acid, and Docusate Sodium
Abstract:Cell and animal models have been used to provide insights
with
regard to physiological changes in intestinal flora due to exposure
to drugs and environmental contaminants. Here, a novel in
vitro model known as simulator of the human intestinal microbial
ecosystem (SHIME) was used to assess the effects of three chemicals
of emerging concern, namely glyphosate, perfluorooctanoic acid (PFOA),
and docusate sodium (dioctyl sulfosuccinate, DOSS), on the lipidomic
and metabolomic profiles of the gut microenvironment … Show more
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