Novel Method for Assessing Myocardial Perfusion. Visualization and Measurement of Intramyocardial Coronary Blood Flow in the Entire Left Ventricular Wall Using Contrast Enhanced, High Frequency Doppler Echocardiography.

Abstract

SUMMARYUsing a high frequency ultrasonic transducer, intramyocardial coronary blood flow (IM-CBF) can be visualized and evaluated during hemodynamic changes in the anterior wall and septum of the left ventricle (LV). We tested the hypothesis that detection and quantitative measurement of IM-CBF of entire LV segments are feasible using a high frequency ultrasonic transducer in conjunction with intravenous contrast injection in vivo.A 3 -8 MHz transducer was used to image and measure IM-CBF in 10 anesthetized dogs. We obtained a color Doppler image of IM-CBF in the LV short-axis view after intravenous Levovist(TM) injection (25 mg / ml). The IM-CBF velocity was recorded using spectral Doppler in the antero-septal and infero-posterior wall of closed chest dogs and in the entire LV after opening the chest. A significant increase in IM-CBF velocity was observed in all LV regions after adenosine 5'-triphosphate (ATP) administration. After Levovist(TM) injection, the visualization of IM-CBF was improved and the spectral Doppler pattern of coronary flow velocity was clarified compared to baseline. IM-CBF was assessed in the antero-septal region of the LV before and after left anterior descending coronary artery occlusion.A high frequency ultrasonic transducer in conjunction with intravenous contrast injection improved IM-CBF visualization, enabling quantitative evaluation of the intramyocardial coronary circulation in the entire LV after coronary occlusion and hyperemia. This study may represent a step towards noninvasive assessment of myocardial perfusion before and after coronary reperfusion. (Jpn Heart J 2001; 42: 101-113)

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“…The transducer was carefully tilted and rotated, using a color doppler image as a guide, until the diastolic coronary blood flow in the LV wall is visualized. Following identification, coronary blood flow velocity was measured by a pulsed wave Doppler technique [48]. All measurements were averaged for 3 consecutive cardiac cycles.…”