Novel Method for Studying Photolability of Topical Formulations: A Case Study of Titanium Dioxide Stabilization of Ketoprofen

Lodén, Marie; Akerström, Ulf; Lindahl, Karin; Berne, Berit

doi:10.1002/jps.20295

Cited by 13 publications

(6 citation statements)

References 23 publications

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“…The photostability of labile substances can be improved by careful combinations of ingredients, and the UV filter octocrylene has been widely used to improve the stability of other UV filters 58 . However, the type of irradiation and surrounding molecules will influence sensitivity and the degradation pattern, making extrapolations into real‐life conditions uncertain 59,60 . Safety studies addressing these potential issues are therefore included in the regulatory requirements.…”

Section: How To Achieve Compliance and Efficacy?mentioning

confidence: 99%

Sunscreen use: controversies, challenges and regulatory aspects

Lodén¹,

Beitner

Gonzalez

et al. 2011

British Journal of Dermatology

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Mismatches between skin pigmentation and modern lifestyle continue to challenge our naked skin. One of our responses to these challenges is the development and use of sunscreens. The management of sunscreens has to balance their protective effect against erythema, photocarcinogenesis and photoageing owing to the potential toxicity of the ultraviolet (UV) filters for humans and the environment. The protection against UV radiation offered by sunscreens was recently standardized in the European Union (EU) based on international harmonization of measurement techniques. Four different categories of sun protection have been implemented along with recommendations on how to use sunscreen products in order to obtain the labelled protection. The UV filters in sunscreens have long been authorized for use by the EU authority on the basis of data from studies on acute toxicity, subchronic and chronic toxicity, reproductive toxicity, genotoxicity, photogenotoxicity, carcinogenicity, irritation, sensitization, phototoxicity and photosensitization as well as on environmental aspects. New challenges with respect to the safety of UV filters have arisen from the banning of animal experiments for the development of cosmetics. Future debates on sunscreens are likely to focus on nanoparticles and environmental issues, along with motivation campaigns to persuade consumers to protect their skin. However, more efficient sunscreen use will also continue to raise questions on the benefit in preventing vitamin D synthesis in the skin induced by sunlight.

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Section: How To Achieve Compliance and Efficacy?mentioning

confidence: 99%

Sunscreen use: controversies, challenges and regulatory aspects

Lodén¹,

Beitner

Gonzalez

et al. 2011

British Journal of Dermatology

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“…It has also been shown that TiO 2 may stabilize ketoprofen and may be used in protecting photounstable species [28]. …”

Section: Discussionmentioning

confidence: 99%

Photostability of commercial sunscreens upon sun exposure and irradiation by ultraviolet lamps

et al. 2007

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Background: Sunscreens are being widely used to reduce exposure to harmful ultraviolet (UV) radiation. The fact that some sunscreens are photounstable has been known for many years. Since the UV-absorbing ingredients of sunscreens may be photounstable, especially in the long wavelength region, it is of great interest to determine their degradation during exposure to UV radiation. Our aim was to investigate the photostability of seven commercial sunscreen products after natural UV exposure (UVnat) and artificial UV exposure (UVart).

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“…The use of TiO 2 as a photoprotector for photolabile active pharmaceutical ingredients (APIs) in dermal drug formulations is very limited, and to date, was tested only for retinoic acid and ketoprofen. However, all the papers confirm the increased photostability due to the use of this inorganic sunscreen, compared to formulations without TiO 2 [13,82,83]. Asfour et al, combined all-trans retinoic acid (ATRA) and TiO 2 for the alleviation of photoinduced sensitivity.…”

Section: Titanium Dioxide Nanoparticles As Photostabilizing Agents In...mentioning

confidence: 99%

Phototoxic or Photoprotective?—Advances and Limitations of Titanium (IV) Oxide in Dermal Formulations—A Review

Gackowski

Osmałek

Froelich

et al. 2023

IJMS

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The widespread role of titanium (IV) oxide (TiO2) in many industries makes this substance of broad scientific interest. TiO2 can act as both a photoprotector and photocatalyst, and the potential for its role in both applications increases when present in nanometer-sized crystals. Its sunlight-scattering properties are used extensively in sunscreens. Furthermore, attempts have been made to incorporate TiO2 into dermal formulations of photolabile drugs. However, the propensity to generate reactive oxygen species (ROS) rendering this material potentially cytotoxic limits its role. Therefore, modifications of TiO2 nanoparticles (e.g., its polymorphic form, size, shape, and surface modifications) are used in an effort to reduce its photocatalytic effects. This review provides an overview of the potential risks arising from and opportunities presented by the use of TiO2 in skin care formulations.

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Novel Method for Studying Photolability of Topical Formulations: A Case Study of Titanium Dioxide Stabilization of Ketoprofen

Cited by 13 publications

References 23 publications

Sunscreen use: controversies, challenges and regulatory aspects

Sunscreen use: controversies, challenges and regulatory aspects

Photostability of commercial sunscreens upon sun exposure and irradiation by ultraviolet lamps

Phototoxic or Photoprotective?—Advances and Limitations of Titanium (IV) Oxide in Dermal Formulations—A Review

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