Novel multifunctional theranostic nanoagents based on Ho3+ for CT/MRI dual-modality imaging-guided photothermal therapy

Xue, Dongzhi; Liu, Yang; Jin, Longhai; Wang, Yinghui; Cui, Fengzhi; Liu, Jianhua; Li, Xiaoqing; Zhang, Songtao; Zhao, Ying; Yin, Na; Niu, Rui; Wang, Daguang; Zhang, Hongjie

doi:10.1007/s11426-020-9920-x

Cited by 13 publications

(7 citation statements)

References 43 publications

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“…Ni et al [ 229 ] presented the first example of T 2 -weighted imaging in an upconversion nanoparticles sensitizer (Yb 3+ ) and activator (Ho 3+ ), and it can also be used in UCL and CT imaging due to the high X-ray attenuation properties and magnetic properties of Ho 3+ . Hence, the system has achieved high-performance multi-modal MRI/UCL/CT imaging in a single upconversion nanoparticle [ 230 ], which facilitates the accurate diagnosis of brain tumors in the preliminary stage. Meanwhile, Zeng’s team [ 231 ] synthesized a new kind of hybrid lanthanide nanoparticles by doping with 0%, 50%, or 100% Ln 3+ (Ln 3+ = Yb 3+ , Er 3+ , or Dy 3+ ), which can be used as T1/T2 dual-weighted MRI contrast agent and mediate tumor diagnosis synergistically.…”

Section: Metal Ions Mediate Cancer Diagnosis and New Nano-theranostic...mentioning

confidence: 99%

New anti-cancer explorations based on metal ions

et al. 2022

J Nanobiotechnol

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Due to the urgent demand for more anti-cancer methods, the new applications of metal ions in cancer have attracted increasing attention. Especially the three kinds of the new mode of cell death, including ferroptosis, calcicoptosis, and cuproptosis, are of great concern. Meanwhile, many metal ions have been found to induce cell death through different approaches, such as interfering with osmotic pressure, triggering biocatalysis, activating immune pathways, and generating the prooxidant effect. Therefore, varieties of new strategies based on the above approaches have been studied and applied for anti-cancer applications. Moreover, many contrast agents based on metal ions have gradually become the core components of the bioimaging technologies, such as MRI, CT, and fluorescence imaging, which exhibit guiding significance for cancer diagnosis. Besides, the new nano-theranostic platforms based on metal ions have experimentally shown efficient response to endogenous and exogenous stimuli, which realizes simultaneous cancer therapy and diagnosis through a more controlled nano-system. However, most metal-based agents have still been in the early stages, and controlled clinical trials are necessary to confirm or not the current expectations. This article will focus on these new explorations based on metal ions, hoping to provide some theoretical support for more anti-cancer ideas.

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Section: Metal Ions Mediate Cancer Diagnosis and New Nano-theranostic...mentioning

confidence: 99%

New anti-cancer explorations based on metal ions

et al. 2022

J Nanobiotechnol

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“…This makes CT imaging especially useful for the evaluation of brain tissue and the CNS. Currently, CT imaging is widely used in the research of brain structure and clinical examination of brain diseases, such as cerebral infarction, cerebral hemorrhage, cerebral ischemia, and tumor [128,129]. To better distinguish the target tissues/organs and surrounding tissues, CT contrast agents that have a high absorption of X-ray photon have been developed to enhance the contrast.…”

Section: Computed Tomography (Ct)mentioning

confidence: 99%

Structural and functional imaging of brains

Liu

Zhu²,

Zhang³

et al. 2022

Sci. China Chem.

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Analyzing the complex structures and functions of brain is the key issue to understanding the physiological and pathological processes. Although neuronal morphology and local distribution of neurons/blood vessels in the brain have been known, the subcellular structures of cells remain challenging, especially in the live brain. In addition, the complicated brain functions involve numerous functional molecules, but the concentrations, distributions and interactions of these molecules in the brain are still poorly understood. In this review, frontier techniques available for multiscale structure imaging from organelles to the whole brain are first overviewed, including magnetic resonance imaging (MRI), computed tomography (CT), positron emission tomography (PET), serial-section electron microscopy (ssEM), light microscopy (LM) and synchrotron-based X-ray microscopy (XRM). Specially, XRM for three-dimensional (3D) imaging of large-scale brain tissue with high resolution and fast imaging speed is highlighted. Additionally, the development of elegant methods for acquisition of brain functions from electrical/chemical signals in the brain is outlined. In particular, the new electrophysiology technologies for neural recordings at the single-neuron level and in the brain are also summarized. We also focus on the construction of electrochemical probes based on dual-recognition strategy and surface/interface chemistry for determination of chemical species in the brain with high selectivity and long-term stability, as well as electrochemophysiological microarray for simultaneously recording of electrochemical and electrophysiological signals in the brain. Moreover, the recent development of brain MRI probes with high contrast-to-noise ratio (CNR) and sensitivity based on hyperpolarized techniques and multi-nuclear chemistry is introduced. Furthermore, multiple optical probes and instruments, especially the optophysiological Raman probes and fiber Raman photometry, for imaging and biosensing in live brain are emphasized. Finally, a brief perspective on existing challenges and further research development is provided.

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“…In addition, Mn is one of the necessary elements in human bodies for metabolism, and its uptake and excretion can be efficiently controlled by biological systems, resulting in low toxicity and high biosafety [ 35 – 37 ]. Notably, single-modal imaging with insufficient diagnostic information sometimes cannot meet the high requirements of modern medicine [ 38 – 41 ]. Therefore, there is increasing interest in the exploration of multi-modal imaging CAs.…”

Section: Introductionmentioning

confidence: 99%

Manganese-based hollow nanoplatforms for MR imaging-guided cancer therapies

et al. 2022

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Theranostic nanoplatforms integrating diagnostic and therapeutic functions have received considerable attention in the past decade. Among them, hollow manganese (Mn)-based nanoplatforms are superior since they combine the advantages of hollow structures and the intrinsic theranostic features of Mn2+. Specifically, the hollow cavity can encapsulate a variety of small-molecule drugs, such as chemotherapeutic agents, photosensitizers and photothermal agents, for chemotherapy, photodynamic therapy (PDT) and photothermal therapy (PTT), respectively. After degradation in the tumor microenvironment (TME), the released Mn2+ is able to act simultaneously as a magnetic resonance (MR) imaging contrast agent (CA) and as a Fenton-like agent for chemodynamic therapy (CDT). More importantly, synergistic treatment outcomes can be realized by reasonable and optimized design of the hollow nanosystems. This review summarizes various Mn-based hollow nanoplatforms, including hollow MnxOy, hollow matrix-supported MnxOy, hollow Mn-doped nanoparticles, hollow Mn complex-based nanoparticles, hollow Mn-cobalt (Co)-based nanoparticles, and hollow Mn-iron (Fe)-based nanoparticles, for MR imaging-guided cancer therapies. Finally, we discuss the potential obstacles and perspectives of these hollow Mn-based nanotheranostics for translational applications. Graphical Abstract Mn-based hollow nanoplatforms such as hollow MnxOy nanoparticles, hollow matrix-supported MnxOy nanoparticles, Mn-doped hollow nanoparticles, Mn complex-based hollow nanoparticles, hollow Mn-Co-based nanoparticles and hollow Mn-Fe-based nanoparticles show great promise in cancer theranostics.

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Novel multifunctional theranostic nanoagents based on Ho3+ for CT/MRI dual-modality imaging-guided photothermal therapy

Cited by 13 publications

References 43 publications

New anti-cancer explorations based on metal ions

New anti-cancer explorations based on metal ions

Structural and functional imaging of brains

Manganese-based hollow nanoplatforms for MR imaging-guided cancer therapies

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